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Extraction method and separation method of cannabidiol

A technology of cannabidiol and separation method, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of high cost, long extraction time, increased cost, etc., and achieve the effect of low cost

Active Publication Date: 2020-08-14
INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first is to use organic solvents as extraction agents, such as methanol, ethanol, n-hexane, etc. However, excessive use of organic solvents and excessive extraction time will increase production costs and bring a series of problems, such as safety sex and environmental protection
The second is the method of supercritical carbon dioxide extraction, but this method requires high-end instruments, and the cost is also high, which limits large-scale application

Method used

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  • Extraction method and separation method of cannabidiol
  • Extraction method and separation method of cannabidiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A method for extracting cannabidiol, comprising the steps of:

[0024] 1) Take fresh marijuana leaves, dry them in a drying oven (setting temperature is 50° C.) to constant weight, then pulverize them with a pulverizer, and sieve them through a 60-mesh sieve. The obtained powder is the starting material.

[0025] 2) Add 0.2g of cannabis leaf powder into the centrifuge tube, use 5mL of hydrophobic ionic liquid as the extraction agent, and extract under ultrasonic-assisted conditions to obtain the extract;

[0026] 3) The extract is centrifuged to take the supernatant to obtain the crude extract of cannabidiol.

[0027] Among them, the hemp leaves were provided by the annual hemp crop breeding team of the Cannabis Research Institute of the Chinese Academy of Agricultural Sciences; the power of the ultrasonic cleaner was 200W, and the main frequency was 40kHz; there were no special restrictions on other experimental drugs, and they were commercially available.

[0028] I...

Embodiment 2

[0050] A method for separating cannabidiol and ionic liquid, comprising the steps of:

[0051] 1) The cannabis crude extract obtained in Example 1 is stripped by a stripping agent to obtain an upper phase and a lower phase, and the upper phase and the lower phase are separated;

[0052] Wherein, the upper phase is a hydrophobic ionic liquid, and the lower phase is cannabidiol; the stripping agent includes n-hexane, ethyl acetate, methanol and water.

[0053] Further, the volume ratio of n-hexane, ethyl acetate, methanol and water is 3:5:3:5. Under these conditions, the purity of cannabidiol obtained after separation reached 31.53%.

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Abstract

The invention relates to a cannabidiol extraction method and separation method. The extraction method comprises the following steps: mixing crushed hemp leaves with a hydrophobic ionic liquid, carrying out ultrasonic extraction, and centrifuging to obtain a cannabidiol crude extract; wherein the hydrophobic ionic liquid is selected from 1-hexyl-3-methylimidazole bis (trifluoromethanesulfonyl) imide salt, 1-octyl-3-methylimidazole bis (trifluoromethanesulfonyl) imide salt, 1-decyl-3-methylimidazole bis (trifluoromethanesulfonyl) imide salt, 1-hexyl-3-methylimidazole hexafluorophosphate, 1-octyl-3-methylimidazole hexafluorophosphate or 1-decyl-3-methylimidazole hexafluorophosphate and composition of the above components. Compared with an organic solvent serving as an extraction agent, the hydrophobic ionic liquid is a novel green solvent, and a series of problems caused by application of an organic solvent in extraction can be avoided. Meanwhile, compared with a supercritical carbon dioxide extraction method, the extraction method does not need high-end instruments and is low in cost.

Description

technical field [0001] The invention relates to the technical field of drug extraction, and more specifically, relates to a method for extracting cannabidiol by using a hydrophobic ionic liquid and a method for separating cannabidiol and the ionic liquid. Background technique [0002] Currently, there are two main methods for extracting cannabidiol from cannabis. The first is to use organic solvents as extraction agents, such as methanol, ethanol, n-hexane, etc. However, excessive use of organic solvents and excessive extraction time will increase production costs and bring a series of problems, such as safety sex and environmental protection. The second method is to use supercritical carbon dioxide extraction, but this method requires high-end instruments and is also expensive, which limits large-scale applications. Contents of the invention [0003] Based on this, aiming at the defects of the two methods for extracting cannabidiol in the prior art, an extraction method...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C37/68C07C39/23C07C37/82
CPCC07C37/68C07C37/82C07C39/23Y02P20/54
Inventor 谭志坚王朝云易永健余旺周晚来李懋曾粮斌杨媛茹汪洪鹰
Owner INST OF BAST FIBER CROPS CHINESE ACADEMY OF AGRI SCI