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A kind of hemostatic powder and preparation method thereof

A technology of hemostatic powder and chitosan, applied in the directions of pharmaceutical formulation, surgery, drug delivery, etc., can solve the problems of high cost and limited hemostatic effect, and achieve the effects of low cost, prevention of microbial infection, and inhibition of microbial infection.

Active Publication Date: 2022-04-19
盐城市盐康医疗器材有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although chitosan has many advantages as a hemostatic material, its own hemostatic effect is relatively limited, and it needs to be combined with other hemostatic agents to achieve the effect on extensive bleeding
Moreover, the cost of this type of hemostatic material is relatively high, so it is not suitable for irregular wounds

Method used

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  • A kind of hemostatic powder and preparation method thereof
  • A kind of hemostatic powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A hemostatic powder and a preparation method thereof, comprising 90% water-soluble chitosan and 10% chitosan hydrochloride by weight percentage.

[0022] The preparation method of described hemostatic powder, comprises the steps:

[0023] Step (1) taking raw materials; by weight percentage, weighing 90% of water-soluble chitosan, 10% of chitosan hydrochloride;

[0024] Step (2) premixing: take by weighing chitosan derivatives and an equal amount of chitosan from step (1), cross a 40-mesh sieve after mixing to obtain mixture A; again weigh an equal amount of chitosan, After mixing with mixture A evenly, pass through a 40-mesh sieve to obtain mixture B;

[0025] Step (3) total mixing: repeat the premixing process of step (2) until all the raw materials are premixed to obtain mixture B, and mix B into a mixer for one hour.

[0026] Step (4) packaging: packaging 500mg / bottle, 1000mg / bottle.

[0027] Step (5) Sterilization: cobalt 60 irradiation sterilization.

Embodiment 2

[0029] A hemostatic powder and a preparation method thereof, comprising 95% slightly soluble chitosan and 5% chitosan lactate in weight percent.

[0030] The preparation method of described hemostatic powder, comprises the steps:

[0031] Step (1) taking raw materials; by weight percentage, weighing 95% of slightly soluble chitosan, 5% of chitosan lactate;

[0032] Step (2) premixing: take by weighing chitosan derivatives and an equal amount of chitosan from step (1), cross a 40-mesh sieve after mixing to obtain mixture A; again weigh an equal amount of chitosan, After mixing with mixture A evenly, pass through a 40-mesh sieve to obtain mixture B;

[0033] Step (3) total mixing: repeat the premixing process of step (2) until all the raw materials are premixed to obtain mixture B, and mix B into a mixer for one hour.

[0034] Step (4) packaging: packaging 500mg / bottle, 1000mg / bottle.

[0035] Step (5) Sterilization: cobalt 60 irradiation sterilization.

Embodiment 3

[0037] A hemostatic powder and a preparation method thereof, comprising 97% water-soluble chitosan and 3% chitosan hydrochloride by weight percentage.

[0038] The preparation method of described hemostatic powder, comprises the steps:

[0039] Step (1) taking raw materials; by weight percentage, weighing 97% of water-soluble chitosan, 3% of chitosan hydrochloride;

[0040] Step (2) premixing: take by weighing chitosan derivatives and an equal amount of chitosan from step (1), cross a 40-mesh sieve after mixing to obtain mixture A; again weigh an equal amount of chitosan, After mixing with mixture A evenly, pass through a 40-mesh sieve to obtain mixture B;

[0041] Step (3) total mixing: repeat the premixing process of step (2) until all the raw materials are premixed to obtain mixture B, and mix B into a mixer for one hour.

[0042] Step (4) packaging: packaging 500mg / bottle, 1000mg / bottle.

[0043] Step (5) Sterilization: cobalt 60 irradiation sterilization.

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Abstract

The invention discloses a hemostatic powder and a preparation method thereof. The method relates to the field of medical instruments. The method comprises the following steps: mixing chitosan with a certain mass ratio with chitosan derivatives, subpackaging, sealing and sterilizing. The hemostatic powder prepared by the invention has good biocompatibility, can prevent and hinder pathogenic microorganisms from infecting the wound, and can keep the wound moist and promote wound healing, and the invention meets the requirements of green processing technology, and the process is simple and convenient, and the production cost is low. bright future.

Description

technical field [0001] The invention specifically relates to a hemostatic powder and a preparation method thereof. Background technique [0002] In today's world, peace and development are the themes of the times, but wars and chaos still exist in some areas. Excessive blood loss in war is the main cause of casualties. The massive bleeding caused by accidents such as car accidents and stab wounds in peaceful areas also seriously threatens people's lives and health. How to quickly stop bleeding during surgery is also an important factor affecting the recovery speed and even life safety of patients. According to the survey, 50% of military deaths are caused by hemorrhage; more than 85% of the deaths in traffic accidents are due to excessive blood loss. Therefore, hemostatic materials have been a research hotspot for Chinese and foreign medical practitioners for a long time. With the development of science and technology, a variety of hemostatic materials with different com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/043A61L24/0042A61L24/0015A61L2300/404A61L2300/418A61L2400/04A61L2300/236C08L5/08
Inventor 王远
Owner 盐城市盐康医疗器材有限公司