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Microneedle patch capable of generating heat and preparation method and application thereof

A technology of microneedle stickers and microneedle arrays, applied in the directions of microneedles, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problem of inability to control drug release and achieve excellent light response Sex, the effect of eliminating white fat

Active Publication Date: 2020-02-11
NANCHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are very few precision weight loss products on the market, and most of them can only achieve partial weight loss without drug release regulation

Method used

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  • Microneedle patch capable of generating heat and preparation method and application thereof
  • Microneedle patch capable of generating heat and preparation method and application thereof
  • Microneedle patch capable of generating heat and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] (1) Preparation of m-HA: Dissolve 2 g of hyaluronic acid in 100 ml of deionized water, add 1.6 ml of methacrylic anhydride dropwise, then use NaoH aqueous solution to adjust the pH value of the mixed liquid to between 8 and 9, and After stirring at 4°C for 24 hours, it was added to pure acetone (polymer:acetone ≈ 1:10, volume ratio), and a milky white precipitate was obtained, which was taken out and washed three times with ethanol. The product was dissolved in deionized water, the solution was dialyzed against deionized water for 2 days, and m-HA was obtained by lyophilization.

[0032] (2) Synthesis of black phosphorus nanosheets: Weigh 2g of NaOH solid into a beaker, add 80ml of N-methylpyrrolidone, ultrasonicate for 5min in a water bath (0-4°C), let stand for 3min after the end, take the supernatant and mix with 20mg black phosphorus powder mixed. Place the mixed solution in a water bath for ultrasonication for 12 hours. After the end, put the centrifuge tube into ...

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Abstract

The invention provides a microneedle patch capable of generating heat, and a preparation method and application thereof. Methyl propene acidulated hyaluronic acid (m-HA) serves as a matrix to load rosiglitazone (Rosi) to produce painless soluble transdermal delivery drug patches, and nano black phosphorus sheets are synthesized to serve as backing for the soluble transdermal delivery drug patches;and the prepared microneedle patch can rapidly generate heat and heat up under excitation of near-infrared light, and drug release can be accelerated.

Description

technical field [0001] The invention relates to medical nanomaterials, in particular to a microneedle patch for local precise weight loss and its preparation method and application. Background technique [0002] In 2014, The Lancet published a research report on overweight and obesity in 188 countries by the Institute for Health Measurement and Evaluation (IHME) of the University of Washington. According to the report, the total number of overweight and obese people in the world increased from 857 million in 1980 to 2.1 billion in 2013. The number of overweight and obese people in China ranks second in the world after the United States, with about 46 million. Obesity is known to lead to various diseases, such as type 2 diabetes and cardiovascular disease. As a result, weight loss therapy has received more and more attention from all walks of life. [0003] Traditional obesity treatment methods mainly include dieting, physical exercise, taking weight-loss drugs, and surger...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/04A61K47/36A61K31/4439A61P3/04A61M37/00
CPCA61K9/0021A61K47/02A61K47/36A61K31/4439A61P3/04A61M37/0015A61M2037/0007A61M2037/0023A61M2037/0053
Inventor 王小磊彭海川张楚汐
Owner NANCHANG UNIV
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