Novel Friedel-Crafts reaction method and catalyst thereof
A catalyst and reaction technology, applied in physical/chemical process catalysts, chemical instruments and methods, organic chemistry, etc., can solve the problems of industrial scale and impracticality of expensive reagents
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Embodiment 4
[0049] Example 4 and figure 1 , and Example 5 and figure 2 Specific examples relating to the use of Friedel-Crafts reactions, including alkylation and acylation, are shown in , each of which is incorporated by reference in its entirety and full scope into this specification section of the invention.
[0050] The chemical novelty and concept of the present invention is to propose a new Friedel-Crafts process using a halogenation catalyst, which can also be combined in an advantageous manner with a fluorination process, in particular without changing the Friedel-Crafts reaction and Catalyst for both fluorination reactions. For example, in preferred embodiments, antimony (Sb) halides, which are commonly used as halogenation catalysts, are used in the present invention, and should be used as Friedel-Crafts catalysts as described herein when the concentration of HF available to activate the catalyst is "low". In an alternative of the present invention, the participation of HF ma...
example 1
[0167] Example 1: 4,4'-Dichlorobenzophenone The synthesis flow, reaction scheme and conditions in a microreactor are as follows.
[0168] 4-Chlorobenzoyl chloride is premixed with HF+catalyst mixture, preferably in a hybrid system (e.g. split and recombination system) to form at least part of chlorobenzoyl fluoride and the corresponding SbHal6-complex, which enters the microreaction in the mixture Device 1 (the material of construction is SiC) previously encountered chlorobenzene.
[0169] The reaction is carried out as a Friedel-Crafts reaction.
[0170] Chemistry (in microreactor, Friedel-Crafts acylation:
[0171]
[0172] low concentration: low concentration
[0173] If a settler of sufficient size is used, the HF-catalyst mixture will separate from the organic matter, mainly 4,4'-dichlorobenzophenone. In the next step, the HF / catalyst mixture needs to be converted into a nucleophilic fluorinating agent by adding excess HF to Sb molar ratio (which should be greater t...
example 2
[0176] CCl according to the invention 4 The pathways and reaction schemes are as follows, and the reaction conditions are as given in Example 1.
[0177] in accordance with CCl 4 This example of a pathway, with CCl 4 The Friedel-Crafts reaction, as shown in the following scheme, uses fluorobenzene as a starting material, which can be obtained by fluorinating chlorobenzene prior to the Friedel-Crafts reaction:
[0178] Chemistry in (microreactor), Friedel-Crafts acylation:
[0179]
[0180] low concentration: low concentration
[0181] The resulting product can be hydrolyzed to form 4,4'-difluorobenzophenone compounds.
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Abstract
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