Drug-loaded sodium alginate nanoparticles with controllable particle size and preparation method thereof
A sodium alginate and nanoparticle technology, applied in nanotechnology, nanotechnology, nanomedicine and other directions, to achieve the effects of good circulation time, improved therapeutic effect and good sustained release.
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[0023] The invention provides a method for preparing drug-loaded sodium alginate nanoparticles with a controllable particle size, which comprises the following steps:
[0024] 1) Dissolve sodium alginate in deionized water, and obtain an aqueous solution of sodium alginate after mechanical stirring and vacuum degassing;
[0025] 2) Pre-freeze the sodium alginate aqueous solution and then freeze-dry to obtain a sodium alginate reactor;
[0026] 3) Add sodium alginate to the aqueous drug solution, and obtain a sodium alginate / drug composite solution after mechanical stirring and vacuum degassing;
[0027] 4) Put the sodium alginate reactor in the sodium alginate / drug composite solution and soak for 2~5h, then take it out and place it in the calcium chloride aqueous solution for cross-linking and solidification, and then place it in an oven to dry to obtain Sodium alginate reactor loaded with sodium alginate nanoparticles;
[0028] 5) Take out the drug-loaded sodium alginate nanoparticles...
Example Embodiment
[0036] Example 1
[0037] 1) Dissolve 3.5 g of sodium alginate in 100 mL of deionized water, and obtain an aqueous solution of sodium alginate with a concentration of 3.5 wt% after mechanical stirring and vacuum degassing;
[0038] 2) Place the sodium alginate aqueous solution in a size of 1×1×1cm 3 Then put it into a -80℃ ultra-low temperature freezer for 4h, and then freeze-dry it by -80℃ freeze dryer for 6h to obtain a sodium alginate reactor;
[0039] 3) Add 1.6 g of sodium alginate to 100 mL of a drug solution with a concentration of 0.4 wt%, and obtain a sodium alginate / drug composite solution with a concentration of 2 wt% after mechanical stirring and vacuum degassing;
[0040] 4) Soak the sodium alginate reactor in the sodium alginate / drug composite solution for 2 hours, then take it out and place it in a 4wt% calcium chloride aqueous solution to solidify for 5 minutes, and then place it in an oven at 40℃ to dry 3h to obtain a sodium alginate reactor loaded with sodium alginat...
Example Embodiment
[0043] Example 2
[0044] 1) Dissolve 2g of sodium alginate in 100mL of deionized water, and obtain a 2wt% aqueous solution of sodium alginate after mechanical stirring and vacuum degassing;
[0045] 2) Place the sodium alginate aqueous solution in a square container with a size of 1×1×1cm3, then put it in a -80℃ ultra-low temperature freezer for 4h, and then freeze-dry it by a -80℃ freeze dryer for 6h to obtain alginic acid Sodium reactor
[0046] 3) Add 2.4 g of sodium alginate to 100 mL of a 0.6wt% aqueous drug solution, and after mechanical stirring and vacuum degassing, a 3wt% sodium alginate / drug composite solution is obtained;
[0047] 4) Soak the sodium alginate reactor in the sodium alginate / drug composite solution for 2 hours, then take it out and place it in a 5wt% calcium chloride aqueous solution to solidify for 5 minutes, and then place it in an oven at 40℃ to dry 3h to obtain a sodium alginate reactor loaded with sodium alginate nanoparticles;
[0048] 5) Take out the s...
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