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Drug-loaded sodium alginate nanoparticles with controllable particle size and preparation method thereof

A sodium alginate and nanoparticle technology, applied in nanotechnology, nanotechnology, nanomedicine and other directions, to achieve the effects of good circulation time, improved therapeutic effect and good sustained release.

Active Publication Date: 2020-02-21
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many studies on using sodium alginate as a carrier to load drugs, but there are few studies that can effectively control the particle size of sodium alginate

Method used

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Examples

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preparation example Construction

[0023] The invention provides a preparation method of drug-loaded sodium alginate nanoparticles with controllable particle size, comprising the following steps:

[0024] 1) Sodium alginate is dissolved in deionized water, and an aqueous solution of sodium alginate is obtained after mechanical stirring and vacuum degassing;

[0025] 2) pre-freezing the sodium alginate aqueous solution and then freeze-drying to obtain a sodium alginate reactor;

[0026] 3) adding sodium alginate to the aqueous drug solution, and obtaining a sodium alginate / drug composite solution after mechanical stirring and vacuum defoaming;

[0027] 4) Soak the sodium alginate reactor in the sodium alginate / drug compound solution for 2 to 5 hours, then take it out and put it in the calcium chloride aqueous solution for cross-linking and solidification, and then dry it in an oven to obtain the Sodium alginate reactor loaded with sodium alginate nanoparticles;

[0028] 5) Take out the drug-loaded sodium algin...

Embodiment 1

[0037] 1) 3.5g of sodium alginate was dissolved in 100mL of deionized water, and after mechanical stirring and vacuum defoaming, a sodium alginate aqueous solution with a concentration of 3.5wt% was obtained;

[0038] 2) Put the sodium alginate aqueous solution in a place with a size of 1×1×1cm 3 Put it into a square container, then put it into a -80°C ultra-low temperature freezer for pre-freezing for 4 hours, and then freeze-dry it through a -80°C freeze dryer for 6 hours to obtain a sodium alginate reactor;

[0039] 3) Add 1.6g of sodium alginate to 100mL of a 0.4wt% drug aqueous solution, and after mechanical stirring and vacuum defoaming, a sodium alginate / drug composite solution with a concentration of 2wt% is obtained;

[0040] 4) Soak the sodium alginate reactor in the sodium alginate / medicine compound solution for 2 hours, then take it out and place it in a 4 wt% calcium chloride aqueous solution for 5 minutes, and then dry it in an oven at 40°C 3h, obtaining a sodiu...

Embodiment 2

[0044] 1) 2 g of sodium alginate was dissolved in 100 mL of deionized water, and after mechanical stirring and vacuum defoaming, a sodium alginate aqueous solution with a concentration of 2 wt % was obtained;

[0045] 2) Put the sodium alginate aqueous solution in a square container with a size of 1×1×1cm3, then put it into a -80°C ultra-low temperature freezer for 4 hours, and then freeze-dry it through a -80°C freeze dryer for 6 hours to obtain alginic acid Sodium reactor;

[0046] 3) Add 2.4g of sodium alginate to 100mL of a 0.6wt% drug aqueous solution, and after mechanical stirring and vacuum defoaming, a sodium alginate / drug composite solution with a concentration of 3wt% is obtained;

[0047] 4) Soak the sodium alginate reactor in the sodium alginate / drug compound solution for 2 hours, then take it out and place it in a 5 wt% calcium chloride aqueous solution to solidify for 5 minutes, and then dry it in an oven at 40°C 3h, obtaining a sodium alginate reactor loaded with...

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Abstract

The invention belongs to the technical field of nano biological materials, and discloses drug-loaded sodium alginate nano particles with a controllable particle size and a preparation method thereof.The preparation method comprises the steps that sodium alginate is dissolved in deionized water, and then a sodium alginate reactor is obtained through stirring, defoaming, pre-freezing and freeze-drying treatment; preparing a sodium alginate / drug composite solution, soaking the sodium alginate reactor in the sodium alginate / drug composite solution, taking out the material, placing the material ina calcium chloride aqueous solution for cross-linking and curing, and drying the material to obtain the sodium alginate reactor loaded with drug-loaded sodium alginate nanoparticles. By adjusting theconcentration of the sodium alginate aqueous solution, holes with different sizes can be formed in the sodium alginate reactor, and then the drug-loaded sodium alginate nanoparticles with proper particle sizes are prepared, so that the targeting property, slow release property and circulation time of the drug-loaded sodium alginate nanoparticles are better, and the treatment effect is further improved. The prepared drug-loaded sodium alginate nanoparticles are controllable in particle size, non-toxic and biodegradable.

Description

technical field [0001] The invention relates to the technical field of nanobiological materials, in particular to drug-loaded sodium alginate nanoparticles with controllable particle size and a preparation method thereof. Background technique [0002] Drug sustained-release system is a kind of drug delivery system, which can make the drug slowly released at a predetermined rate, so as to achieve the purpose of controlling the drug concentration in the body. The traditional way of drug delivery can only be maintained for a short period of time, and often exceeds the maximum tolerance value of the human drug, causing toxic and side effects, such as gastrointestinal reactions. Based on this, the microparticle drug-carrying system came into being, and its carriers mostly use polymer materials, including biodegradable synthetic polymers and natural macromolecules. In order to solve the disadvantages of traditional drug delivery methods, it is necessary to consider that the carri...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K47/36B82Y5/00
CPCA61K9/19A61K47/36B82Y5/00
Inventor 陈春升毛庆辉葛建龙张芮崔建伟
Owner NANTONG UNIVERSITY
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