Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Tricyanodihydrofuran-quinolone cooperation compound preparation method

A technology of tricyanodihydrofuran and quinolones, which is applied in chemical instruments and methods, fluorescence/phosphorescence, instruments, etc., can solve the problems of cumbersome sample preparation and complicated operation, and achieves high sensitivity, mild reaction conditions and fast speed. Effect

Pending Publication Date: 2020-02-21
JIAMUSI UNIVERSITY
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for preparing tricyanodihydrofuran-quinolone complexes in order to solve the problems of cumbersome sample preparation and complicated operation in the existing quinolone complex analysis and detection methods

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tricyanodihydrofuran-quinolone cooperation compound preparation method

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0013] Specific embodiment one: what this embodiment records is a kind of preparation method of tricyanodihydrofuran-quinolone complex, described method is:

[0014] Weigh tricyanodihydrofuran DCDHF-2-V and ofloxacin OFLX according to the molar ratio of 1:1, dissolve tricyanodihydrofuran in chloroform, the amount of chloroform can dissolve tricyanodihydrofuran That is, ofloxacin is dissolved in anhydrous methanol (ultrasound-assisted dissolution), the completely dissolved tricyanodihydrofuran solution and ofloxacin solution are mixed, the pH is adjusted to 5.5 with a buffer solution, and the shock is even. Leave it at room temperature for 30 minutes.

specific Embodiment approach 2

[0015] Specific embodiment two: the preparation method of a kind of tricyanodihydrofuran-quinolone complex described in specific embodiment one, the volume concentration of described anhydrous methanol is 99.9%; Described chloroform is used as organic solvent, volume concentration 99.9%.

specific Embodiment approach 3

[0016] Specific embodiment three: the preparation method of a kind of tricyanodihydrofuran-quinolone complex described in specific embodiment one, in the process that ofloxacin is dissolved in anhydrous methanol, control the molar concentration of anhydrous methanol 1×10 - 3 mol / L.

[0017] Embodiment 4: The method for preparing a tricyanodihydrofuran-quinolone complex described in Embodiment 1, the buffer solution is a mixed solution of hexamethylenetetramine and hydrochloric acid. The preparation process is as follows: Weigh 40g of hexamethylenetetramine, add 100ml of water and 10ml of concentrated hydrochloric acid to dissolve and shake well, measure the pH value of the solution with a pH meter, and adjust the pH value to 5.4-5.5 (pH value When the pH is lower than 5.4, add hexamethylenetetramine, and when the pH value is higher than 5.5, add hydrochloric acid) is related to the buffer pair.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a tricyanodihydrofuran-quinolone cooperation compound preparation method, and belongs to the technical field of cooperation compound preparation. A purpose of the invention isto solve the problems of complex sample preparation and complex operation of the existing quinolone cooperation compound analysis and detection method. The tricyanodihydrofuran-quinolone cooperation compound preparation method comprises: weighing tricyanodihydrofuran and ofloxacin according to a molar ratio of 1:1; dissolving the tricyanodihydrofuran in chloroform, and dissolving the ofloxacin inabsolute methanol; and mixing the completely dissolved tricyanodihydrofuran solution and the ofloxacin solution, regulating the pH value to 5.5 by using a buffer solution, oscillating uniformly, and standing at a room temperature for 30 min. Compared with the method in the prior art, the preparation method disclosed by the invention achieves the determination of the content of quinolone-based drugs while prepares the tricyanodihydrofuran-quinolone cooperation compound, and further has characteristics of mild reaction conditions, rapid reaction and high sensitivity.

Description

technical field [0001] The invention belongs to the technical field of complex preparation, and in particular relates to a preparation method of tricyanodihydrofuran-quinolone complexes. Background technique [0002] The study of complex life activities is a hot topic in the field of life sciences, and molecular recognition related to chemical probe molecules plays an important role in its research. Molecular recognition refers to the selective combination of receptors and substrates When it is activated, certain specific changes or specific functions will occur and then affect the surrounding environment system. It is a specific interaction between biomolecules. Fluorescence has many practical advantages as a sensing signal for molecular recognition. Fluorescent molecular probes can convert changes in the microscopic world into signals in the macroscopic world that can be perceived by the outside world, realizing the dialogue between us and microscopic molecules and ions, b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D307/30C07D498/06C09K11/06G01N21/64
CPCC07D498/06C07D307/30C09K11/06G01N21/643C09K2211/1033C09K2211/1044C09K2211/1088
Inventor 王伟娥江欣杨慧李冬辉赵雅欣高蕻冰吕玉光
Owner JIAMUSI UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com