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Application of marker for predicting prognosis of acute liver failure to preparation of kit for predicting prognosis evaluation of acute liver failure

A technology for acute liver failure and prognosis assessment, applied in the field of biomedicine, can solve problems such as no proteomic data linking

Pending Publication Date: 2020-02-21
成都市第五人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, neither of them linked proteomic data to post-treatment outcomes

Method used

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  • Application of marker for predicting prognosis of acute liver failure to preparation of kit for predicting prognosis evaluation of acute liver failure
  • Application of marker for predicting prognosis of acute liver failure to preparation of kit for predicting prognosis evaluation of acute liver failure
  • Application of marker for predicting prognosis of acute liver failure to preparation of kit for predicting prognosis evaluation of acute liver failure

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] This example provides the application of markers for predicting the prognosis of acute liver failure in the preparation of a kit for predicting the prognosis of acute liver failure, the markers for predicting the prognosis of acute liver failure include complement factor B and plasma protease C1 inhibitor , coagulation factor XII and apolipoprotein C-1.

[0062] The kit can detect the expression levels of complement factor B, plasma protease C1 inhibitor, blood coagulation factor XII and apolipoprotein C-1 in the serum of HBV-ACLF patients, so that the prognosis of acute liver failure can be predicted.

Embodiment 2

[0064] This embodiment verifies the technical solution of embodiment 1 through experiments.

[0065] 1. Experimental design and clinical characteristics of patients with HBV-ACLF

[0066] Screened according to the inclusion and exclusion criteria, 24 patients participated in this study, including 11 survivors (group S) and 13 deaths (group D). The clinical characteristics of these patients are shown in Table 1.

[0067] Table 1 Clinical information of patients with HBV-associated ACLF

[0068]

[0069]

[0070] *, p-value < 0.05; **, p-value < 0.01. Leukocytes, whole blood cells; Plt, platelets; ALT, glutamate-pyruvate aminotransferase; TBil, total billrubin; CHE, cholinesterase; albumin; Cr, creatinine; PT, prothrombin time; PTA, prothrombin Activity; INR, International Normalized Coagulation Time Ratio; FIB, Fibrinogen; Child, Child-Turcotte-Pugh; MELD, Model of End-Stage Liver Disease.

[0071] It can be seen from Table 1 that, except prothrombin time (PTs, p=0.02...

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Abstract

The invention discloses application of a marker for predicting the prognosis of acute liver failure to the preparation of a kit for predicting prognosis evaluation of acute liver failure. The marker for predicting the prognosis of the acute liver failure comprises a complement factor B, a plasma protease C1 inhibitor, a blood coagulation factor XII and an apolipoprotein C-1. According to the method, HBV-ACLF comparative proteomics analysis provides high-throughput iTRAQ analysis of survived and dead patients for HBV-ACLF patients on the day of hospitalization and four weeks after treatment; anew insight is provided for the proteome spectrums of HBV related ACLF patients with completely different prognosis; four proteins, namely the complement factor B (CFB), the plasma protease C1 inhibitor (PPC1), the blood coagulation factor XII (CF12) and the apolipoprotein C-1 (APO-CI), are determined so as to be used as the prognostic biomarkers of the HBV-ACLF.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to the application of ITIH3 and APO-C1 in the preparation of an ELISA kit for predicting the prognosis of acute liver failure. Background technique [0002] Acute-chronic liver failure (ACLF) is a condition belonging to the subgroup of cirrhotic patients who develop organ failure after hospitalization for hepatitis B virus infection. HBV-associated ACLF is the leading risk factor for liver failure [1-3] . Inflammatory disease is thought to be a major factor in the development of ACLF, although the pathophysiology of this condition remains unclear [4，5] . ACLF is characterized by rapid progression leading to short- and medium-term mortality rates as high as 50-90% [6] . Outcome of the syndrome estimated by systemic cardiac and hepatic hemodynamics [7，8] . However, if ACLF patients receive appropriate treatment, it is possible to restore the original state of liver function...

Claims

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Application Information

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IPC IPC(8): G01N33/576G01N33/68G01N30/02
CPCG01N33/5761G01N33/6848G01N30/02Y02A90/10
Inventor 王燕王晓忠雷建国冯蕾郭峰苟萍
Owner 成都市第五人民医院
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