A composition containing a mixture of quinazoline derivatives and an application thereof

A composition and derivative technology, applied in the field of medicine, can solve problems that need to be further improved

Inactive Publication Date: 2020-03-06
黄泳华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical Biology, 2019, 10(03): 226-230.) The extracts of plants such as horn wind, six ear bells, rattan notoginseng, Guanzhong, golden thread grass, unipedal wind, eight hundred centimeters, and piercing stone have the effect on tobacco Ralstonia solanacearum at 100mg / L and / or 500mg / L Certain antibacterial activity, but the inventors found that the antibacterial activity of the above-mentioned plant extracts to other common pathogenic bacteria needs to be further improved

Method used

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  • A composition containing a mixture of quinazoline derivatives and an application thereof
  • A composition containing a mixture of quinazoline derivatives and an application thereof
  • A composition containing a mixture of quinazoline derivatives and an application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0021] The preparation of preparation example 1 plant extract

[0022] Ultrasonic extraction method is used to dry the shade-dried plant material at 40°C, crush it, pass through a 40-mesh sieve, and put it into a ziplock bag. Before the test, 50 g of plant dry powder was weighed, and different organic solvents were added for ultrasonic extraction (as shown in Table 1), and the extraction was repeated 3 times for 60 min each time. After filtration, it was concentrated to dryness and stored in a refrigerator at 4°C until use.

[0023] Table 1 Organic solvents for ultrasonic extraction of different plant extracts

[0024] plant material Extract number Organic solvents cistanche PE1 Methanol broken bone PE2 n-heptane red yaozi PE3 Chloroform Peace of mind PE4 n-heptane Eight hundred percent PE5 ethyl acetate Guanzhong PE6 Isopropanol mountain star anise PE7 Dichloromethane

Embodiment 1

[0102] The preparation of the solid preparation of the composition that embodiment 1 contains quinazoline derivative mixture

[0103] prescription

[0104]

[0105]

[0106] Preparation

[0107] Take the prescribed amount of MIX (X-Y-PEZ) and auxiliary materials, and pass through a 100-mesh sieve. Take MIX (X-Y-PEZ), lactose, microcrystalline cellulose, crospovidone and starch and mix thoroughly; take the prescribed amount of hypromellose, and prepare it into a product with a concentration of 10% based on hypromellose Solution, adjust the pH to 3.0-4.0 with lactic acid, add to the above-mentioned mixed material to make a soft material, granulate with a 16-mesh sieve, and dry at 80°C for 3-4 hours. Use a 16-mesh sieve to sieve, add the prescribed amount of micropowder silica gel and magnesium stearate, mix well, and fill into capsules with a weight of about 500 mg each;

[0108] Take the prescribed amount of MIX (X-Y-PEZ) and auxiliary materials, and pass through a...

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PUM

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Abstract

The invention provides a composition containing a mixture of a first quinazoline derivative and a second quinazoline derivative which are different from each other. The specific definition of the quinazoline derivatives is shown in the specification. The mixture disclosed by the invention can synergistically enhance the inhibition effect of extracts of plants, such as boschniakia rossica, on bacteria, such as grass green aerococcus.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition containing a mixture of quinazoline derivatives and an application thereof. Background technique [0002] Nosocomial infection is an important issue affecting the quality of hospital care. With the continuous development and progress of modern medical technology, antibacterial drugs are widely used, and the drug-resistant strains of clinical pathogens are increasing. Therefore, improving the antibacterial activity of existing drugs will help to improve the therapeutic effect of patients with bacterial infections. [0003] CN110283052A discloses that two quinazoline compounds with the structures shown in formula I and formula II have certain antibacterial activity against various bacteria. [0004] [0005] Plant extracts are rich in a variety of ingredients with antibacterial activity. For example, Yang Ruoying et al. reported (Journal of Tropical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/517A61K36/64A61K36/63A61K36/704A61K36/48A61K36/12A61K36/746A61P31/04
CPCA61K31/517A61K36/12A61K36/48A61K36/63A61K36/64A61K36/704A61K36/746A61P31/04A61K2300/00
Inventor 向飞于新新
Owner 黄泳华
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