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Topical compositions comprising pichia anomala and a soy product

A kind of Pichia anomaly, a composition technology, applied in the field of topical composition comprising Pichia anomaly and soybean products

Inactive Publication Date: 2020-03-10
JOHNSON & JOHNSON CONSUMER COPANIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, injected hyaluronic acid has a limited lifespan
On the other hand, it has proven difficult to penetrate exogenous hyaluronic acid into the skin by topical application

Method used

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  • Topical compositions comprising pichia anomala and a soy product
  • Topical compositions comprising pichia anomala and a soy product
  • Topical compositions comprising pichia anomala and a soy product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0127] The production of hyaluronic acid (HA) in human dermal fibroblasts after cells were treated with extracts of Pichia pastoris and / or soybean products was measured and compared as follows.

[0128] The soybean product is glycine soybean seed extract (commercially available from Devansoy, Inc. (Rock City, IL)), and it is a powder. It was resuspended in phosphate buffered saline (PBS) to prepare a 10% (weight / volume) stock solution. The stock solution is then further diluted in cell culture medium to reach the final test concentration.

[0129] The extract of Pichia anomalous is in the form of a 5% aqueous solution. Pichia anomalous has grown on kiwi plants. Treat a 5% aqueous solution as a 100% stock solution.

[0130] The two components are added to the culture medium at the stated doses individually or together, and their resulting effects on HA production are used to determine the fold change compared to untreated HA production.

[0131] The human dermal fibroblasts were mai...

Embodiment 2

[0139] After treatment with test compositions A, B and C (comparative) and compositions 1 and 2 (according to the invention) containing different amounts of abnormal Pichia pastoris extract and soy products, human skin explants were measured and compared The hyaluronic acid (HA) is produced. The test composition contained the ingredients shown in Table 2.

[0140] Table 2

[0141]

[0142]

[0143] An abnormal Pichia yeast extract was prepared as described in Example 1.

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Abstract

The present invention relates to topical compositions comprising pichia anomala and a soy product, and provides a topical composition comprising an extract of Pichia anomala and a soy product.

Description

[0001] Cross references to related applications [0002] This application claims the benefits of U.S. Provisional Application 62 / 724807 filed on August 30, 2018, the entire disclosure of which is hereby incorporated by reference for all purposes. Technical field [0003] The present invention provides a method of treating skin by topically applying a combination of an extract of Pichia pastoris and a soybean product to the skin to treat the skin. In addition, the present invention provides a topical composition comprising a combination of an extract of Pichia anomalous and a soybean product. Background technique [0004] Hyaluronic acid is present in the periphery of collagen and elastin fibers and in the skin where these fibers intersect. Hyaluronic acid is not only located in the dermis, but also in the intercellular space of the epidermis, especially in the middle spinous layer, but not in the stratum corneum (SC) or granular layer. In aging skin, the level of hyaluronic acid d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P17/00A61P17/18A61K8/9789A61K8/9728A61Q19/00A61Q19/08
CPCA61K8/345A61Q19/00A61Q19/08A61K8/9728A61K8/9789A61K36/064A61K36/48A61P17/00A61P17/18A61K2300/00A61K9/0014A61K47/10A61Q19/007A61Q17/00
Inventor F·刘-沃尔什M·伽雷P·迈特拉M·兰德哈瓦
Owner JOHNSON & JOHNSON CONSUMER COPANIES
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