Dihydroisoindole-1H-pyrazolo[3,4-d]pyrimidone compound, and preparation method and application thereof

A compound, C1-C4 technology, applied in organic chemistry, drug combination, metabolic diseases, etc., can solve the problems of unlikely distribution of AZD1775, limited efficacy, limited applicability of brain tumor treatment, etc., and achieve good blood-brain barrier permeability , high therapeutic index, good safety effect
CN110872296AActive Publication Date: 2020-03-10上海弘翊生物科技有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海弘翊生物科技有限公司
Publication Date
2020-03-10

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Abstract

The invention relates to a series of compounds represented as the formula (I), or pharmaceutically acceptable salts thereof, which can be used as new-generation Wee1 selective inhibitor. Compared withexisting Wee1 inhibitor, the compound has a higher selectivity on Wee1 kinase, so that the compound is safer and is higher in treatment index, and also has higher blood brain barrier permeability. The compound has better safety and a larger applicable range, and can be applied to treatment on various tumors, including brain tumor.
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Description

technical field

[0001] The invention relates to a class of dihydroisoindole-1H-pyrazolo[3,4-d]pyrimidinone compounds, a preparation method thereof, and a pharmaceutical composition containing the compound, which are used for preparing and treating cancer and precancerous syndrome drugs or supplementary drugs.

[0002] Background of the invention

[0003] Cell cycle checkpoints are a set of inspection mechanisms to ensure the quality of DNA replication and chromosome allocation during cell cycle progression. When abnormal events occur during the cell cycle process, such as DNA damage or DNA replication blockage, this kind of regulatory mechanism is activated to interrupt the progress of the cell cycle in time, and the cell cycle can only resume operation after the cell is repaired or the fault is eliminated. The core component of the cell cycle regulation system is the CDKs / Cyclins complex formed by the combination of cyclin-dependent kinases (CDKs) and cyclins (Cyclins), whi...

Claims

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