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Application of maggot or extract thereof in preparation of medicine for reducing renal toxicity

A technology of nephrotoxicity and extracts, applied in the field of application of grain worms or their extracts in the preparation of drugs that reduce nephrotoxicity, capable of solving problems such as dose limitation, toxicity, and kidney production

Active Publication Date: 2020-03-17
浙江佰科堂生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term administration of anti-tumor drugs in cancer patients will cause nephrotoxicity, and the choice of dosage is limited in the course of clinical application

Method used

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  • Application of maggot or extract thereof in preparation of medicine for reducing renal toxicity
  • Application of maggot or extract thereof in preparation of medicine for reducing renal toxicity
  • Application of maggot or extract thereof in preparation of medicine for reducing renal toxicity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1: the preparation of grain worm extract

[0066] Prepare the grain worm extract according to the following method:

[0067] 1. Artificially cultured grain worms were freeze-dried, crushed and passed through a 60-mesh sieve, and then extracted with carbon dioxide fluid supercritically. The extraction parameters were pressure 25MPA, temperature 50°C, CO 2 The flow rate was 25 L / h, and the extraction was performed for 2 hours to obtain a crude product.

[0068] 2. Heat the crude product obtained in step 1 to 80°C, add 3% of the volume of the crude product in 80°C distilled water, stir for 30 minutes, and mix thoroughly; centrifuge at 5000r / min to remove the precipitate to obtain degummed grease.

[0069] 3. Take the degummed oil obtained in step 2, heat it to 60°C, add 0.3% (w / w) sodium hydroxide, stir for 1 hour, fine saponified matter appears, raise the temperature to 80°C, flocs appear and coagulate, 5000r / min centrifugal separation. Take the supernatant,...

Embodiment 2

[0071] Embodiment 2: the preparation of grain insect powder

[0072] Artificially cultured grain worms were freeze-dried, crushed and passed through a 100-mesh sieve for later use.

Embodiment 3

[0073] Embodiment 3: the preparation of the pharmaceutical composition comprising grain worm or its extract and riboflavin

[0074] Pharmaceutical composition 1: the ratio of five grain insect extract:riboflavin in the active ingredient is 120:1 (mass ratio).

[0075] Pharmaceutical composition 2: in the active ingredient, the ratio of grain worm extract:riboflavin is 100:1 (mass ratio).

[0076] Pharmaceutical composition 3: the ratio of five grain insect extract:riboflavin in the active ingredient is 80:1 (mass ratio).

[0077] Pharmaceutical composition 4: the ratio of five grain insect extract:riboflavin in the active ingredient is 50:1 (mass ratio).

[0078] Pharmaceutical composition 5: the ratio of five grain insect powder:riboflavin in the active ingredient is 100:1 (mass ratio).

[0079] Pharmaceutical composition 6: the ratio of five grain insect powder:riboflavin in the active ingredient is 80:1 (mass ratio).

[0080] Pharmaceutical composition 7: the ratio of fi...

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Abstract

The invention relates to an application of maggot or extract thereof in preparation of a medicine for reducing renal toxicity. The invention also provides a pharmaceutical composition for reducing renal toxicity. The pharmaceutical composition comprises the maggot or extract thereof and riboflavin.

Description

technical field [0001] The invention relates to a new application of the grain worm, in particular, the use of the grain worm or its extract for preparing medicines for reducing nephrotoxicity. Background technique [0002] Many existing drugs are nephrotoxic, causing renal failure through various mechanisms, including direct toxicity to the renal tubules, allergic interstitial nephritis, and intratubular occurrence of drugs that may cause oliguric renal failure crystallization etc. Drugs that can cause nephrotoxicity include anticancer agents, such as cisplatin, methotrexate, and doxorubicin; nonsteroidal antiinflammatory drugs (NSAIDs), such as COX-2 inhibitors; antibiotics, eg, aminoglycosides, amphotericin; antiviral agents such as acyclovir, indinavir; acetylcholinesterase inhibitors; angiotensin II receptor blockers (ARBs); lithium and radiographic contrast agents, etc. [0003] Conventional methods used to treat tumor diseases have certain toxic effects on many org...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K31/525A61P13/12
CPCA61K31/525A61K35/64A61P13/12A61K2300/00
Inventor 黄玉水
Owner 浙江佰科堂生物科技股份有限公司
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