Degradable bioactive screw and manufacturing method thereof

Abstract

The invention discloses a degradable bioactive screw and a manufacturing method thereof. The screw is composed of three parts including a tail part, a middle part and a head part, and the three partsare located on the same central axis; the tail part comprises a column body and a groove located in the end face of the column body; the middle part comprises a cylinder body connected with the columnbody, storage cavities located in the cylinder body, and a medicine distributed in the storage cavity, each storage cavity comprises a release layer and a channel connected with the release layer, threads are arranged on the surface of the cylinder body; and the head part comprises a circular truncated cone connected with the cylinder body and a hemisphere located on the end face of the circulartruncated cone. The method for manufacturing the degradable bioactive screw is convenient to operate and low in manufacturing cost, the screw in any shape and size can be manufactured according to needs, and meanwhile the screw has good biocompatibility and osteoinductivity.

Description

technical field [0001] The invention relates to the manufacture of interface screws in intra-articular ligament reconstruction, in particular to a biodegradable bioactive screw and a manufacturing method thereof. Background technique [0002] Arthroscopic ligament reconstruction is currently an effective surgical treatment for intra-articular ligament injuries and restoration of joint stability and function. However, the problem of bone-ligament interface healing still plagues the majority of clinicians. Once the ligament-bone interface is poorly healed, it is likely to lead to the failure of the entire operation. [0003] At present, the commonly used method of ligament fixation in clinic is fixation with absorbable interface screws through the bone marrow canal. The interface screws are constructed from poly-L-lactic acid (PLLA). PLLA has good biocompatibility and suitable degradation speed. With the absorption of its own material, the bone tissue fills the entire tunnel...

AI Technical Summary

Problems solved by technology

However, PLLA has no biological activity and cannot induce osteogenesis. The mismatch between the bone formation speed in the tunnel and the degree of PLLA absorption will cause the tunnel to expand and the ligament to be fixed unstable.

Clinically, the current use of composite hydroxyapatite absorbable screws has a certain degree of improvement in the induction of osteogenesis, but its mechanical strength is low, and there are differences between artificially synthesized composite hydroxyapatite and hydroxyapatite in human bones , leading to poor bone formation

At the same time, some screws will loosen in the medullary canal, resulting in failure of ligament fixation

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