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Degradable bioactive screw and manufacturing method thereof

A bioactive, screw technology, applied in the field of biodegradable bioactive screws and their manufacturing, can solve the problems of low mechanical strength, tunnel expansion, screw loosening, etc., and achieve high mechanical strength, fast and low-cost manufacturing, and good ligament fixation effect.

Active Publication Date: 2020-03-27
HANGZHOU DIANZI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PLLA has no biological activity and cannot induce osteogenesis. The mismatch between the bone formation speed in the tunnel and the degree of PLLA absorption will cause the tunnel to expand and the ligament to be fixed unstable.
Clinically, the current use of composite hydroxyapatite absorbable screws has a certain degree of improvement in the induction of osteogenesis, but its mechanical strength is low, and there are differences between artificially synthesized composite hydroxyapatite and hydroxyapatite in human bones , leading to poor bone formation
At the same time, some screws will loosen in the medullary canal, resulting in failure of ligament fixation

Method used

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  • Degradable bioactive screw and manufacturing method thereof
  • Degradable bioactive screw and manufacturing method thereof
  • Degradable bioactive screw and manufacturing method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0071] 1) Mix the calcium magnesium silicate powder and the photosensitive resin solution uniformly according to the mass percentage of 1.1:1 to obtain a uniformly dispersed bio-ink, and mix atorvastatin with a 5% polyvinyl alcohol solution to obtain Drug-loaded polyvinyl alcohol solution.

[0072] 2) According to the shrinkage rate of the material before and after sintering, the final shape and size of the screw, design the model before calcination, and convert the model into an STL file format that can be recognized by the light-curing printer, and then import it into the light-curing printer.

[0073] 3) Add the bio-ink configured in step 1) into the liquid storage tank of the light-curing printer, start the light-curing printer, and the printer will cure the bio-ink layer by layer according to the designed parameters, and finally get the screw blank.

[0074] 4) Wash the screw blank in step 3) with water to remove the uncured bio-ink on the surface of the screw blank and i...

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Abstract

The invention discloses a degradable bioactive screw and a manufacturing method thereof. The screw is composed of three parts including a tail part, a middle part and a head part, and the three partsare located on the same central axis; the tail part comprises a column body and a groove located in the end face of the column body; the middle part comprises a cylinder body connected with the columnbody, storage cavities located in the cylinder body, and a medicine distributed in the storage cavity, each storage cavity comprises a release layer and a channel connected with the release layer, threads are arranged on the surface of the cylinder body; and the head part comprises a circular truncated cone connected with the cylinder body and a hemisphere located on the end face of the circulartruncated cone. The method for manufacturing the degradable bioactive screw is convenient to operate and low in manufacturing cost, the screw in any shape and size can be manufactured according to needs, and meanwhile the screw has good biocompatibility and osteoinductivity.

Description

technical field [0001] The invention relates to the manufacture of interface screws in intra-articular ligament reconstruction, in particular to a biodegradable bioactive screw and a manufacturing method thereof. Background technique [0002] Arthroscopic ligament reconstruction is currently an effective surgical treatment for intra-articular ligament injuries and restoration of joint stability and function. However, the problem of bone-ligament interface healing still plagues the majority of clinicians. Once the ligament-bone interface is poorly healed, it is likely to lead to the failure of the entire operation. [0003] At present, the commonly used method of ligament fixation in clinic is fixation with absorbable interface screws through the bone marrow canal. The interface screws are constructed from poly-L-lactic acid (PLLA). PLLA has good biocompatibility and suitable degradation speed. With the absorption of its own material, the bone tissue fills the entire tunnel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/064
CPCA61B17/0642A61B2017/00004
Inventor 邵惠锋贺永傅建中龚友平刘海强陈慧鹏李文欣陈国金
Owner HANGZHOU DIANZI UNIV
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