Large-visual field multi-modal imaging system

Abstract

The invention proposes a large-visual field multi-modal imaging system. The system includes an illumination subsystem, an infinity relay imaging subsystem and a data processing subsystem; and the dataprocessing subsystem is used to calculate a blood flow velocity in an area to be measured according to a speckle signal received by an image sensor, calculate a hemoglobin concentration in the area to be measured according to a reflected light intensity signal received by the image sensor, and calculate a relative oxygen metabolism rate according to registration of the obtained blood flow velocity and hemoglobin concentration. According to the large-visual field multi-modal imaging system provided by embodiments of the invention, the infinity relay imaging subsystem is added, so that a spectroscopic component can be conveniently inserted into the relay subsystem to provide more imaging optical paths, and the system realizes data collection of the blood flow velocity and the hemoglobin concentration without switching light sources and is conducive to real-time, large-visual field multi-modal tissue hemodynamic parameter monitoring.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to a large field of view multimodal imaging system. Background technique [0002] Simultaneous monitoring of tissue hemodynamic parameters such as blood flow, blood oxygen, and blood volume has important clinical significance and is helpful for evaluating physiological or pathological states. [0003] In related technologies, relative blood flow is calculated by analyzing fluctuations of dynamic speckle patterns by laser speckle blood flow imaging technology, which has the advantages of real-time, full-field, and non-contact, and has been widely used in clinical practice. It has been reported in the literature that LSCI (Laser speckle signal, laser speckle signal), OIS (Optical intrinsic signal imaging) and other technologies such as fluorescence imaging technology are combined to realize multi-modal monitoring of hemodynamic signals. [0004] However, for the acquisition...

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Problems solved by technology

[0004] However, for the acquisition of clinical macroscopic information, most of the photographic lenses with large field of view currently used have standard interfaces such as C-mount and F-mount. Since the working distance behind them is too short to insert spectroscopic or filter elements, the current photographic lens Most of the lens is realized by switching the light source, which greatly reduces the time resolution of the imaging system, which is not conducive to real-time, large-field multi-modal tissue hemodynamic parameter monitoring

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