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A traditional Chinese medicine spray for treating nasotracheal ornithosis of green-shell layer hens and its preparation method

A green-shell laying hen, spray technology, applied in aerosol delivery, antibacterial drugs, pharmaceutical formulations, etc., can solve problems such as the inability to use antibiotics for prevention or treatment, achieve no drug resistance, ensure drug concentration, and effect obvious effect

Active Publication Date: 2021-11-26
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, vaccines are mainly used to prevent the disease, but there is no relevant vaccine in my country; at the same time, the bacteria have developed resistance to multiple antibiotics, and antibiotics cannot be used for prevention or treatment on green-shell laying hens. Therefore, It is imminent to develop a new type of anti-nasopharyngeal ornithosis with high efficiency, low toxicity and no drug residue

Method used

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preparation example Construction

[0025] The present invention also includes a preparation method of a traditional Chinese medicine spray for treating nasotracheal ornithosis of green-shell laying hens, comprising the following steps:

[0026] Step 1, weighing: by weight, weigh the following components: 15-20 parts of Cortex Mori, 15-20 parts of perilla leaves, 10-15 parts of Cimicifuga, 5-12 parts of Rubia;

[0027] Step 2. Mix the weighed components, add water for injection 8 times the mass of the medicinal materials, carry out the first distillation and extraction at a temperature of 90°C-100°C for 1.5 hours-2.5 hours, and collect the distillate, which is The first aromatic water, wherein the volume-to-mass ratio (ml / g) of the first aromatic water to Cortex Mori is 100:375-100:500, and then the medicinal residue is distilled for the second time at 90°C-100°C Extract for 1 hour to 1.5 hours, collect the distillate, which is the second aromatic water, wherein the volume of the second aromatic water and the fi...

Embodiment 1

[0042] Step 1. Take 45kg of Cortex Mori, 40kg of perilla leaves, 35kg of Cimicifuga, and 30kg of Rubia, add water for injection 8 times the quality of traditional Chinese medicine, carry out the first distillation and extraction at 100°C for 2 hours, collect 100L of distillate, It is the first aromatic water. Under the temperature condition of 100℃, the medicinal dregs are distilled and extracted for 1.5 hours for a second time, and 50L of distillate is collected, which is the second aromatic water. The two aromatic waters are combined into 150L for the third distillation to 35L , add co-solvent Tween 80 300ml, mix well, get the prepared third aromatic water;

[0043] Step 2, using the same method as above to prepare the prepared third aromatic water, set aside;

[0044] Step 3. After collecting the third aromatic water in step 2, add 8 times the amount of water for injection to the medicinal dregs, decoct twice for 45 minutes each time, filter through three layers of gauze, a...

Embodiment 2

[0051] Step 1. Take 37.5kg of Cortex Mori, 50kg of Perilla leaves, 25kg of Cimicifuga, and 30kg of Rubia, add water for injection 8 times the quality of traditional Chinese medicine, conduct the first distillation and extraction at 90°C for 2.5 hours, and collect 100L of distillate , which is the first aromatic water. The medicinal dregs were distilled and extracted for a second time at 90°C for 2.5 hours, and 50L of distillate was collected, which was the second aromatic water. The two aromatic waters were combined into 150L for the third distillation to 35L, add co-solvent Tween 80 200ml, mix thoroughly to get the prepared third aromatic water;

[0052] Step 2, using the same method as above to prepare the prepared third aromatic water, set aside;

[0053] Step 3. After collecting the third aromatic water in step 2, add 8 times the amount of water for injection to the dregs, decoct 2 times, 60 minutes each time, filter through three layers of gauze, combine the 2 decoctions ...

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Abstract

The invention discloses a traditional Chinese medicine spray for treating nasotracheal ornithosis of green-shell layer hens and a preparation method thereof. The traditional Chinese medicine spray comprises the following components in parts by weight: 15-20 parts of Cortex Mori and 15 parts of perilla leaves ‑20 parts, Cimicifuga 10‑15 parts, madder 5‑12 parts. The preparation method is as follows: mixing the above-mentioned components and adding water for injection, carrying out three distillation extractions to obtain the third aromatic water, adding co-solvent Tween 80 to the third aromatic water to obtain the prepared third aromatic water; Add 8 times the amount of water for injection, decoct and filter, combine the decoction and the prepared third aromatic water, add ethanol, concentrate to obtain the concentrated solution, and adjust the pH; add the prepared third aromatic water to the adjusted pH concentrated solution. Aromatic water, benzoic acid and paraben are added to water for injection to make up volume, and sterilized to prepare a spray. The spray of the invention has obvious effect on treating the nasotracheal ornithosis of green-shell layer hens.

Description

technical field [0001] The invention belongs to the field of veterinary medicine products for poultry, and in particular relates to a traditional Chinese medicine spray for treating nasotracheal avian bacillus disease of green-shell laying hens and a preparation method thereof. Background technique [0002] The large-scale development of the chicken industry has led to the large-scale and intensive development of broiler and laying hens in the breeding process. The three-dimensional layer cages are used to raise them, showing a high-density feeding method. Green-shell hens, named after producing green-shell eggs, are characterized by the green shell color of the eggs. It is a unique poultry species in China and is listed as a "National Special Resource Protection Project" by the Ministry of Agriculture. This chicken breed has strong disease resistance, wide adaptability, likes to eat green grass and vegetable leaves, and its feeding management is similar to other chickens. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/74A61K9/12A61P31/04A61P29/00A61P11/06
CPCA61K9/0078A61K9/12A61K36/535A61K36/605A61K36/71A61K36/74A61K47/26A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P11/06A61P29/00A61P31/04A61K2300/00
Inventor 舒刚黄远玲任静唐子婷袁宇彭佳昊张远南徐丹欧达亮苏毅赵小玲
Owner SICHUAN AGRI UNIV
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