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Immunoadsorbent, preparation method thereof and adsorber for blood perfusion

A technology of immunoadsorbent and solvent, which is applied in the direction of solid adsorbent liquid separation, separation method, suction device, etc., to achieve the effect of reducing pain, being easy to use, and relieving the disease

Active Publication Date: 2020-04-10
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Triptolide is one of the first-choice drugs for the clinical treatment of rheumatoid arthritis, but currently there is no triptolide immobilized on an adsorbent that can be used to adsorb pathogenic substances of immune diseases such as rheumatoid arthritis Adsorbent and hemoperfusion reported, so it is necessary to develop the adsorbent

Method used

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  • Immunoadsorbent, preparation method thereof and adsorber for blood perfusion
  • Immunoadsorbent, preparation method thereof and adsorber for blood perfusion
  • Immunoadsorbent, preparation method thereof and adsorber for blood perfusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The adsorbent carrier is polystyrene-divinylbenzene, the linker is pyromellitic anhydride, the ligand is triptolide, and based on the ester group bonding method, triptolide is grafted and immobilized on the adsorbent carrier, Wherein the structural formula of triptolide is:

[0041]

[0042] 1 Preparation of adsorbent carrier

[0043] 1.1 Preparation of chloromethylated polystyrene-divinylbenzene microspheres

[0044] The reaction scheme of chloromethylated polystyrene-divinylbenzene microspheres is as follows: figure 1 Shown: Step ①, polystyrene-divinylbenzene is produced by suspension polymerization of styrene and divinylbenzene; Step ②, react polystyrene-divinylbenzene with chloromethyl ether under the catalysis of zinc chloride Produces chloromethylated polystyrene-divinylbenzene.

[0045] The specific operation steps are as follows: use styrene as a monomer, divinylbenzene as a crosslinking agent, polyvinyl alcohol (PVA) with a mass concentration of 0.5% to 3...

Embodiment 2

[0056] The adsorbent carrier in Example 2 is polystyrene-divinylbenzene microspheres, the linker is succinic anhydride, and the adsorbent carrier is grafted with triptolide based on the ester group bonding method. The polystyrene-divinylbenzene microspheres in Example 2 also need to be chloromethylated, and the specific method is the same as that of the polystyrene-divinylbenzene microspheres in Example 1.

[0057] 1 Preparation of adsorbent carrier

[0058] 1.1 Modification of polystyrene-divinylbenzene carrier:

[0059] Add 20 mL of chloromethylated polystyrene-divinylbenzene microspheres into 4 mol / L sodium hydroxide aqueous solution, stir and react for 24 hours, after the reaction is completed, wash with purified water several times until the pH of the washing liquid is neutral, Alcoholized polystyrene-divinylbenzene microspheres are obtained after drying.

[0060] 2 grafting arm introduction

[0061]The reaction scheme of the polystyrene-divinylbenzene microspheres gra...

Embodiment 3

[0067] The main difference between this embodiment 3 and embodiment 2 is that the dosage of triptolide is 5 mg, the preparation method of the adsorbent is the same as that of the adsorbent in embodiment 2, and the arrangement of the adsorbent in the adsorber in this embodiment It is the same as the arrangement mode of the adsorbent in the adsorber in Example 1.

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Abstract

The present invention provides an immunoadsorbent. The immunoadsorbent comprises a carrier, a grafting connection arm and a ligand, the carrier and the grafting connection arm are covalently connected, and the grafting connection arm is connected to the ligand through a connection group; and the carrier is selected from polystyrene-divinylbenzene or a composition of polystyrene-divinylbenzene andone or more of crosslinked polyvinyl alcohol, polypropylene, chitosan, cellulose, agarose and glucan, and the ligand is selected from tripterygium wilfordii extract and a derivative thereof. The invention also provides a preparation method of the immunoadsorbent and an adsorber for blood perfusion by adopting the immunoadsorbent. Compared with a traditional administration mode, blood circulation makes pathogenic factors in blood directly removed, triptolide can play a role in an in-vitro hemoperfutor, toxic damage to organs and tissues of a patient in the mode of entering the human body is avoided, drug resistance of the patient is avoided, and convenience is brought to use of medical staff.

Description

technical field [0001] The invention relates to the field of hemoperfusion adsorbents, in particular to an immunoadsorbent, a preparation method thereof, and an adsorber for hemoperfusion. Background technique [0002] Immunoadsorption is a conventional treatment method, which removes pathogenic antibodies, antigens and immune complexes in the blood of patients with autoimmune diseases by taking the patient's blood out of the body and passing it through a hemoperfusion device, using the immunosorbent in the hemoperfusion device to achieve The purpose of purifying the blood and relieving the disease. Immunosorbents can remove excess creatinine, β2 microglobulin, pathogenic antibodies, antigens, and immune complexes in the blood of patients with immune kidney disease, and can also remove similar substances in the blood of patients with rheumatoid arthritis. Rheumatoid factor (RF) is specifically removed to reduce the deposition of immune complexes in damaged joints and blood ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01D15/38B01D15/22A61M1/36B01J20/30
CPCB01J20/267A61M1/362B01D15/22B01D15/3809Y02A50/30
Inventor 董凡房玉庆赵琪
Owner JAFRON BIOMEDICAL
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