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A kind of hplc content determination method of shenzhuerkang syrup

A determination method and Shenzhuer technology are applied in the field of HPLC content determination of Shenzhuerkang syrup to achieve the effect of improving quality controllability

Active Publication Date: 2022-07-01
HARBIN KANGLONG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can determine the content of Polygonum multiflorum, but it is not suitable for the content determination of other medicinal materials.

Method used

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  • A kind of hplc content determination method of shenzhuerkang syrup
  • A kind of hplc content determination method of shenzhuerkang syrup

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Embodiment Construction

[0010] In a common embodiment, the HPLC (high performance liquid phase) method used in the content determination method claimed in the present invention, the necessary linear relationship such as chromatographic conditions, system suitability test, reference substance preparation and test substance preparation, etc., Reproducibility and stability are all within the concept of the present invention, and can be investigated in accordance with the statutory methodology of the drug administration department, which is not specifically limited in the present invention.

[0011] In some embodiments of the preferred chromatographic conditions and system suitability test, the column is a chromatographic column with octadecylsilane bonded silica gel as the filler; acetonitrile, methanol, 0.1% phosphoric acid / 5% glacial acetic acid / 1% The acid mixture of trifluoroacetic acid is used as the mobile phase for gradient elution; the detection wavelength is 203-254 nm; One or more of 21 acid a...

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Abstract

The invention relates to an HPLC content determination method for Shenzhuerkang syrup, which comprises simultaneous determination of Taizishen (measured by Taizishen cyclopeptide B), Poria (as 3β-hydroxy-lanoster-7, 9(11), 24-triene-21 acid), one or more content determination methods in licorice (in ammonium glycyrrhizinate). The beneficial effect of the invention is that the quality controllability of Shenzhuerkang syrup is improved.

Description

technical field [0001] The invention belongs to the field of drug analysis, and particularly relates to an HPLC content determination method for Shenzhuerkang syrup. Background technique [0002] There are as many as 16 medicinal materials in Shenzhuerkang Syrup. However, in the current quality standard (WS-11246(ZD-1246)-2002-2012Z-2017), the content of tangerine peel was determined by HPLC only in terms of hesperidin. The chromatographic conditions and system suitability test conditions are that octadecylsilane-bonded silica gel is used as the filler, methanol-5% glacial acetic acid (43:57) is used as the mobile phase, and the detection wavelength is 283 nm, which is not suitable for the content of other medicinal materials. Determination. "Asia-Pacific Traditional Medicine", Volume 14, Issue 12, December 2018, "Determination of Glycyrrhizic Acid in Licorice and Shenshuerkang Syrup by HPLC", established an HPLC method for the determination of glycyrrhizic acid in Licorice...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/047
Inventor 穆滨惠建梅翟斌
Owner HARBIN KANGLONG PHARM CO LTD