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A kind of preparation method of pharmaceutical composition, pharmaceutical preparation and emulsion for treating echinococcosis

A technology of pharmaceutical preparations and compositions, which is applied in the field of parasitic disease medicine and can solve problems such as poor clinical effects

Active Publication Date: 2021-02-12
QINGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on this, it is necessary to provide an effective drug with isoeugenol methyl ether, D-camphor and camphene as active ingredients to solve the problem of poor clinical efficacy of current echinococcosis drugs

Method used

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  • A kind of preparation method of pharmaceutical composition, pharmaceutical preparation and emulsion for treating echinococcosis
  • A kind of preparation method of pharmaceutical composition, pharmaceutical preparation and emulsion for treating echinococcosis
  • A kind of preparation method of pharmaceutical composition, pharmaceutical preparation and emulsion for treating echinococcosis

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preparation example Construction

[0027] A preparation method for a pharmaceutical preparation for the treatment of echinococcosis, the pharmaceutical preparation being an emulsion, the preparation method comprising the steps of:

[0028] (1) Raw material preparation: take 30 parts of isoeugenol methyl ether, 8 parts of D-camphor, and 5 parts of camphene according to parts by weight for use;

[0029] (2) Emulsion preparation: Take isoeugenol methyl ether in a mortar, add D-camphor and camphene, mix and grind to dissolve evenly, add an appropriate amount of gum arabic to grind to make it evenly dispersed, and then add an appropriate amount of distilled water to grind continuously to obtain milky white colostrum. Grinding while adding water, the emulsion is obtained after dilution. .

[0030] Compared with the prior art, the present invention has the following advantages:

[0031] The pharmaceutical composition and pharmaceutical preparation of the present invention can be used to treat echinococcosis. The act...

Embodiment

[0033] 1. Experimental materials:

[0034] Isoeugenol / D-camphor / camphene: Isoeugenol with a purity of 98%, purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.; D-camphor: with a purity of 96%, purchased from Shanghai Yuanye Biology Technology Co., Ltd.; Camphene: 78% purity, purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.

[0035] Two, the preparation of treatment echinococcosis drug emulsion:

[0036] Take 2.5 mL of isoeugenol methyl ether and place it in a mortar, add D-camphor and amphene in proportions of 30 parts by weight of isoeugenol methyl ether, 8 parts of D-camphor, and 5 parts of amphene, mix and grind to dissolve evenly, add Grind 1.25 g of gum arabic to disperse evenly, then add 2.5 mL of distilled water to continuously grind to obtain milky white colostrum, grind while adding water, and dilute to 50 mL to obtain an emulsion.

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Abstract

The invention relates to a pharmaceutical composition, a pharmaceutical preparation and an emulsion preparation method for treating hydatid disease. The active components of the pharmaceutical composition include isoeugenol methyl ether, D-camphor and camphene. The pharmaceutical preparation is made from the above-mentioned pharmaceutical composition and pharmaceutically acceptable excipients, and its dosage forms include emulsions, tablets, powders, pills, granules, capsules and the like. At the same time, it also relates to a preparation method of the emulsion in the above-mentioned pharmaceutical preparation. The pharmaceutical composition and pharmaceutical preparation of the present invention can be used to treat hydatid disease, and the active pharmaceutical components isoeugenol methyl ether, D-camphor and camphene can effectively reduce the number of vesicles and the hydatid disease animal model in combination with the in vivo level. It can kill the protozoa in the vesicles of cystic hydatid disease at the in vitro level, and has a good therapeutic effect on hydatid disease.

Description

technical field [0001] The invention relates to the technical field of parasitic disease medicine, in particular to a pharmaceutical composition, pharmaceutical preparation and emulsion preparation method for treating echinococcosis. Background technique [0002] Hydatid disease ( Echinococcosis ) is a zoonotic parasitic disease caused by the infection of Echinococcus genus Taenia, also known as echinococcosis. In my country, it is mainly divided into cystic echinococcosis ( Cystic Echinococcosis ; CE) and alveolar echinococcosis ( Alveolar Echinocococosis ; AE), respectively Echinococcus granulosus ( Echinococus granulosus ) and Echinococcus multilocularis ( Echinocococus multilocularis ) infection. Echinococcus granulosus usually exists in mammals such as cattle, sheep, and pigs in the form of larvae, while Echinococcus multilocularis mainly uses rodents such as mice as intermediate hosts, and humans are occasional hosts of Echinococcus granulosus / multilocularia ....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/125A61K31/015A61K31/09A61K9/107A61K47/36A61P33/10
CPCA61K9/107A61K31/015A61K31/09A61K31/125A61K47/36A61P33/10A61K2300/00
Inventor 李占强汤锋樊海宁李润乐格日力芦殿香杨占婷李珂华玉美多刘海生
Owner QINGHAI UNIVERSITY