1,2-Dioxane[3,4-f]Nitrooxycyclononane Derivatives and Their Synthesis and Application

Abstract

The invention discloses a series of 1,2-dioxcyclohexene [3,4-f]nitrogenated cyclononane derivatives, their synthesis method and application. The 1,2-dioxane[3,4-f]nitroxycyclononane derivative of the present invention has the structure shown in the following formula (I), and its synthesis method mainly includes the following steps: take the following formula The compound shown in (II), the compound shown in formula (III), the photosensitizer and the catalyst are placed in an organic solvent, and react under light irradiation in the presence of oxygen to obtain the crude product of the target compound. The method of the invention is simple and easy to control, and some target compounds obtained have good anti-inflammatory activity and certain potential medicinal value. The compounds of structures shown in the formula (I), formula (II) and formula (III) are respectively as follows:

Description

technical field

[0001] The invention relates to 1,2-dioxcyclohexene[3,4-f]nitroxocyclononane derivatives and a synthesis method and application thereof, belonging to the technical field of medicine. Background technique

[0002] Organic peroxides are compounds in which peroxygen is bonded to carbon atoms. For a long time the greatest use of this class of compounds has been as free radical initiators. Until the 1970s, Chinese scientists discovered artemisinin, a natural product with excellent antimalarial activity, in which the peroxy bond in the molecule is the key to its antimalarial activity. Organic peroxides began to be highly valued by the medical and biological circles, and gradually aroused brand-new interest in the chemical circles. And the synthesis of this kind of peroxy compound, its key step and difficult point is exactly how to form or introduce peroxy bond. Natural sources of organic peroxides are limited and usually only small amounts of each compound can b...

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