41 results about "Cyclononane" patented technology

The invention provides a method for preparing a moxifloxacin intermediate (S,S)-2,8-diazabicyclo[4,3,0]nonane, and relates to the technical field of organic synthesis. The present invention uses azaphthalide as a raw material. Due to the cyclic structure of azaphthalide itself, the other two non-responsive chiral isomers that are not needed in chiral reduction are hardly produced, and the reduced intermediate itself The chiral purity is very high, no further resolution is required, and (S,S)‑2,8‑diazabicyclo[4,3,0 ] Nonane. The method provided by the invention does not need chiral resolution, has simple process, short process steps, low cost, high chiral purity of products and high total yield. Furthermore, in the subsequent steps of product salification and refining, there is no need to use carboxylic acids containing chiral structures to form salts, and ordinary achiral carboxylic acids can be used for refining to further improve product purity.

The invention discloses a synthesis method of 3,7-dinitro-1,3,5,7-4-azabicyclo[3,3,1]nonane, which comprises the following steps of: (1) adding 20% of fuming sulfuric acid to 98% of fuming nitric acid to prepare a mixed acid; adding urea in batches in the mixed acid at -5 DEG C and stirring for 40-90 min; (2) adding reaction liquid obtained in the step (1) in an ammonia spirit with the concentration of 28% and the temperature of -10-0 DEG C; and keeping the temperature at 0-5DEG C and stirring for 10-30 min; (3) adding 37% of formaldehyde solution in the reaction solution obtained in the step(2); and than raising the temperature to 40-65DEG C and stirring for 10-30 min; and then cooling to 20-25 DEG C, wherein the mole ratio of methanal and urea is 4.0-6.5:1.0; (4) adding ammonia spirit with the concentration of 28% in the reaction liquid obtained in the step (3) while keeping stirring; regulating the pH value of the reaction system to be 7-7.5 and regulating the temperature to be 20-25 DEG C; filtering and settling; washing with water and drying to obtain 3,7-dinitro-1,3,5,7-4-azabicyclo[3,3,1]nonane. The invention is mainly used for synthesizing 3,7-dinitro-1,3,5,7-4-azabicyclo[3,3,1]nonane.