41 results about "Cyclononane" patented technology

The invention provides a method for preparing a moxifloxacin intermediate (S,S)-2,8-diazabicyclo[4,3,0]nonane, and relates to the technical field of organic synthesis. The present invention uses azaphthalide as a raw material. Due to the cyclic structure of azaphthalide itself, the other two non-responsive chiral isomers that are not needed in chiral reduction are hardly produced, and the reduced intermediate itself The chiral purity is very high, no further resolution is required, and (S,S)‑2,8‑diazabicyclo[4,3,0 ] Nonane. The method provided by the invention does not need chiral resolution, has simple process, short process steps, low cost, high chiral purity of products and high total yield. Furthermore, in the subsequent steps of product salification and refining, there is no need to use carboxylic acids containing chiral structures to form salts, and ordinary achiral carboxylic acids can be used for refining to further improve product purity.

The invention discloses a method for preparing a ligand of a pulp and fabric low-temperature bleaching catalyst. The main steps include: dissolving diethylenetriamine with a sulfonyl group in an organic solvent, adding an alkaline reagent and ethylene glycol dicarboxylic acid ester, react at 80-150°C for 6-20 hours, after the reaction, cool to room temperature and filter to obtain 1,4,7-trisulfonyl-1,4,7-triazacyclononane; Add the solid to sulfuric acid, stir at 80-130°C for 2-12 hours, add alkali to neutralize after cooling down, then add formaldehyde and formic acid to reflux to obtain 1,4,7-trimethyl-1,4,7-triaza Cyclononane. The preparation method of the invention is simple, the raw materials are easy to obtain, and the three wastes are less, which is suitable for industrial production and meets the environmental protection requirements of the current industrial production.

The invention discloses a synthesis method of 3,7-dinitro-1,3,5,7-4-azabicyclo[3,3,1]nonane, which comprises the following steps of: (1) adding 20% of fuming sulfuric acid to 98% of fuming nitric acid to prepare a mixed acid; adding urea in batches in the mixed acid at -5 DEG C and stirring for 40-90 min; (2) adding reaction liquid obtained in the step (1) in an ammonia spirit with the concentration of 28% and the temperature of -10-0 DEG C; and keeping the temperature at 0-5DEG C and stirring for 10-30 min; (3) adding 37% of formaldehyde solution in the reaction solution obtained in the step(2); and than raising the temperature to 40-65DEG C and stirring for 10-30 min; and then cooling to 20-25 DEG C, wherein the mole ratio of methanal and urea is 4.0-6.5:1.0; (4) adding ammonia spirit with the concentration of 28% in the reaction liquid obtained in the step (3) while keeping stirring; regulating the pH value of the reaction system to be 7-7.5 and regulating the temperature to be 20-25 DEG C; filtering and settling; washing with water and drying to obtain 3,7-dinitro-1,3,5,7-4-azabicyclo[3,3,1]nonane. The invention is mainly used for synthesizing 3,7-dinitro-1,3,5,7-4-azabicyclo[3,3,1]nonane.

The invention discloses a series of 1,2-dioxcyclohexene [3,4-f]nitrogenated cyclononane derivatives, their synthesis method and application. The 1,2-dioxane[3,4-f]nitroxycyclononane derivative of the present invention has the structure shown in the following formula (I), and its synthesis method mainly includes the following steps: take the following formula The compound shown in (II), the compound shown in formula (III), the photosensitizer and the catalyst are placed in an organic solvent, and react under light irradiation in the presence of oxygen to obtain the crude product of the target compound. The method of the invention is simple and easy to control, and some target compounds obtained have good anti-inflammatory activity and certain potential medicinal value. The compounds of structures shown in the formula (I), formula (II) and formula (III) are respectively as follows:

The invention provides a preparation process for racemic cis-8-benzyl-2,8-diazabicyclo[4,3,0]nonane, which comprises the following steps: Step S1: preparing an attachment carrier: immersing a solid carrier into Prepare an attachment carrier in a roughening solution, the roughening solution is a sodium hydroxide solution or a sodium bifluoride solution; Step S2: Prepare a platinum dehydrogenation catalyst: use an impregnation method to support the precious metal platinum by impregnating it into an impregnation solution containing noble metal ions On the solid carrier, in parts by weight, the impregnation solution includes 30-40 parts of chloroplatinic acid and 1-5 parts of rice furoic acid; step S3: piperidine ring dehydrogenation reaction; step S4: high-pressure hydrogenation reaction. The invention provides a method for preparing racemic cis-8-benzyl-2,8-diazabicyclo[4,3,0]nonane with high selectivity, high catalytic efficiency and high product purity.

The invention belongs to the technical field of organic synthesis and particularly discloses a method for preparing a macrolide precursor. The method comprises the following steps: (1) mixing cyclohexanone and hydrogen peroxide, further adding a ferric salt catalyst, carrying out a reaction for 1-8 hours at the room temperature, and carrying out column chromatography separation after the reactionis completed so as to obtain a main product 1,1'-dihydroperoxide dicyclohexyl peroxide; (2) condensing the main product with cyclohexanone under catalysis of an organic acid, and after the reaction ends, carrying out separation and purification, thereby obtaining the macrolide precursor 1,2,4,5,7,8-hexaoxa-3,6,9-tricyclohexylidene cyclononane. The cyclohexanone which is low in price and easy to obtain is adopted as a raw material, and the product is prepared through two steps of reactions under catalysis of a ferric salt and a small amount of the organic acid at 20-45 DEG C; the method is simple and convenient in process, high in yield, applicable to popularization and application, and the product prepared by using the method can be applied to fields such as a cigarette fixative agent.

The invention relates to the technical field of organic chemical synthesis, and relates to a method for synthesizing 5-fluoro-1-azabicyclo[3, 2, 2]nonane and derivatives thereof. The preparation method comprises the following steps: reacting a 4-(hydroxymethyl)quinuclidine derivative with a fluorinating reagent at normal temperature, rearranging one six-membered ring of a quinine ring to obtain afluorine substituted product of a seven-membered ring, carrying out extraction, solvent removal and concentration on a reaction mixture, and carrying out column chromatography separation or sublimation to obtain pure 5-fluoro-1-azabicyclo[3, 2, 2]nonane and derivatives thereof. The 5-fluoro-1-azabicyclo[3, 2, 2]nonane and the derivative thereof are obtained through one-step synthesis by reacting the 4-(hydroxymethyl)quinuclidine derivative with the fluorinating reagent, and the method is discovered for the first time. The synthesis method is simple, has few synthesis steps, is easy to separate, and can realize large-scale synthesis of target products.