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Topical treatment for preventing and mitigating skin cytotoxicity due to therapy with tyrosine kinase inhibitors

A tyrosine kinase and inhibitor technology, applied in the field of topical preparations based on resveratrol glycosides, can solve the problems of aggravated sunlight exposure, reduced protection, irritation and the like

Inactive Publication Date: 2020-04-17
EUCARE SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sunscreens with high protection factors should be used immediately because inhibition of EGF receptors reduces the protection of the receptors themselves, exacerbating irritation symptoms from sun exposure

Method used

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  • Topical treatment for preventing and mitigating skin cytotoxicity due to therapy with tyrosine kinase inhibitors
  • Topical treatment for preventing and mitigating skin cytotoxicity due to therapy with tyrosine kinase inhibitors
  • Topical treatment for preventing and mitigating skin cytotoxicity due to therapy with tyrosine kinase inhibitors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Formulation A: liposomes in water, resveratrol glycosides for dermatological diseases

[0047] Lecithin (5-10%), Oleyl Erucate (5%), Resveratrol Glycosides (0.5-2%), Tocopheryl Acetate (3%), Magnesium Sulfate (2%), Ethyl Ethyl Glycerin (Ethylexylglycerin) (0.5%), Phenoxyethanol (0.6%).

Embodiment 2

[0049] Formulation B: liposomes in water, resveratrol glycosides for dermatological diseases

[0050] Lecithin (5-10%), Dicapryl Ether (5%), Resveratrol Glycosides (0.5-2%), Tocopheryl Acetate (3%), Magnesium Sulfate (2%), Ethyl Glycerin (Ethylexylglycerin) (0.5%), Phenoxyethanol (0.6%).

Embodiment 3

[0052] Formulation C: Emulsion in water, resveratrol glycosides for dermatological diseases

[0053] Emulsifier: Tego care PBS 6 (2-4%), caprylic / capric triglycerides (10%), stearyl and cetyl alcohols (2%), cetyl palmitate (2%), resveratrol Rutrol Glycoside (0.5-2%), Human Ceramide (SK-INFLUX) (2%), Tocopheryl Acetate (2%), Thickener (0.4%), pH Corrector (0.1%), Preservative Mixture (0.6%), Phenoxyethanol (0.6%).

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Abstract

The invention relates to the use of a topical preparation based on 3,4,5'-trihydroxystilbene-3-p-mono-d-glucoside (polydatin or piceid, or resveratrol-3-beta-mono-D-glucoside) a glycosylated derivative of resveratrol, for the prophylaxis and management of adverse skin and mucosal reactions in the therapy with tyrosine kinase inhibitor antitumor drugs, in particular tyrosine kinase inhibitors of EGF receptors (EGFR-TKI). The prophylaxis is performed by applying a polydatin-based topical preparation to the skin and / or mucous membranes at least once a day and before administration of the antitumor drug, to protect the skin from adverse effects of the anticancer treatment, such as skin rash, acneiform dermatitis, itching, ungual alterations, cutaneous xerosis or stomatitis.

Description

technical field [0001] The present invention relates to topical treatments for the prevention and reduction of skin cytotoxicity caused by tyrosine kinase inhibitory drugs, especially EGFR inhibitors. More specifically, the invention relates to topical formulations based on resveratrol glycosides (resveratrol glycosides are glycosylated derivatives of resveratrol) for application on the skin prior to treatment with antineoplastic tyrosine kinase inhibitors. , also known as piceid) to protect the skin from adverse cutaneous effects of systemic therapy with this drug. Background technique [0002] In recent years, new knowledge about the molecular biology of altered proliferative signaling in tumor cells has become a rationale for the development of so-called "molecularly targeted biotherapies" (also called "targeted therapies"), which have far-reaching implications compared with conventional chemotherapy. innovative significance. In fact, although chemotherapy acts on all t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/517A61K31/5377A61K31/7034A61P39/00A61P17/00A61K39/395
CPCA61K39/395A61K31/517A61K31/5377A61K31/7034C07K16/2863A61K2039/54A61P39/00A61P17/00A61K2300/00
Inventor 玛丽亚·孔切塔·罗曼诺詹彼得罗·拉瓦尼安
Owner EUCARE SRL