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A combination of metabolites and its screening method for preoperative warning of delayed recovery of transplanted kidneys in donors after cardiac death

A technology of cardiac death and screening methods, applied in the field of analysis, can solve the problems that the difference analysis has not been reported, and achieve the effect of reducing the probability of occurrence and delaying recovery

Active Publication Date: 2021-08-31
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the analysis of delayed recovery events in kidney transplantation based on metabolomics technology comes from the postoperative samples of recipients, and the difference analysis of donors before surgery has not been reported.

Method used

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  • A combination of metabolites and its screening method for preoperative warning of delayed recovery of transplanted kidneys in donors after cardiac death
  • A combination of metabolites and its screening method for preoperative warning of delayed recovery of transplanted kidneys in donors after cardiac death
  • A combination of metabolites and its screening method for preoperative warning of delayed recovery of transplanted kidneys in donors after cardiac death

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Embodiment 1

[0032] DGF after kidney transplantation is a common clinical adverse event, and the diagnosis standard is that the urine output is low within 1 week after the operation and the need for dialysis transition. Two kidneys from the same donor will have differences in functional recovery in different recipients. According to the postoperative renal function recovery of both recipients, DCD kidney transplant donors are grouped: DGF occurs in both recipients after surgery. The donors of the 2 groups were the Double-DGF group, and the donors whose renal functions of both recipients had recovered and stabilized were the None-DGF group, and blood samples were obtained from the above 2 groups.

[0033] The stable recovery of renal function was defined as the stable postoperative serum creatinine within 20% of the baseline value, and no postoperative complications such as acute rejection, lymphatic leakage, urinary fistula, perirenal hematoma, and polyoma virus infection occurred. The dia...

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Abstract

The invention discloses a metabolic composition for preoperative early warning and delayed recovery of transplanted kidneys of donated donors after cardiac death, which consists of ascorbic acid, diaminopimelic acid, cinnamic acid, ureidoisobutyric acid, androstenedione, One or more of the seven metabolites of 3‑oxoctanoic acid and uroporphyrin. The invention also discloses a screening method for the metabolic composition used for early warning of the delayed recovery of the transplanted kidney of the donated donor after cardiac death. The binding indicator rate was 0.823, and the binding indicator rate of cinnamic acid, ureidoisobutyric acid, androstenedione, 3‑oxoctanoic acid and uroporphyrin was 0.98.

Description

technical field [0001] The invention belongs to the technical field of analysis, and in particular relates to a metabolic composition and a screening method for early warning of delayed recovery of transplanted kidney of a donor after cardiac death. Background technique [0002] Delayed graft function (DGF) is a clinical phenomenon that cannot restore physiological function within one week after kidney transplantation and requires dialysis transition, and is an independent risk factor affecting the survival of transplanted kidney [P.N.C.D.S.M.etal., Delayed graft function in kidney transplantation. Lancet, 2004. 364(9447)]. In recent years, with the promotion of donation after cardiac death (DCD), the incidence of DGF has increased significantly. On the one hand, the acquisition of DCD kidneys can only be carried out after the donor’s cardiac function has stopped, so the donor kidney will experience a longer warm ischemia time than the living donor kidney, and the renal mic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/36G01N30/72G01N30/88G16C20/64G16C20/70
CPCG01N30/02G01N30/06G01N30/34G01N30/36G01N30/7266G01N30/88G01N2030/027G01N2030/8822G16C20/64G16C20/70
Inventor 沈佳邓皓陈德莹黄洪锋陈江华王仁定
Owner ZHEJIANG UNIV
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