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Medicine composition and application thereof in preparation of medicine for treating lung cancer

A composition and drug technology, applied in the application of drugs, in the application field of increasing the body weight of cancer patients, can solve the problems of not bringing the benefit of overall survival, lack of therapeutic drugs, etc., and achieve prolongation of progression-free survival, The effect of prolonging overall survival and gaining weight

Inactive Publication Date: 2020-04-28
林丽珠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although drugs such as pemetrexed can prolong disease progression-free survival, they do not bring overall survival benefits in the end. In addition, hematological toxicity and fatigue caused by maintenance chemotherapy make most patients choose to stop the drug
In addition, there are drugs targeting angiogenesis, such as bevacizumab, which can prolong survival; but there is a lack of therapeutic drugs targeting the tumor microenvironment

Method used

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  • Medicine composition and application thereof in preparation of medicine for treating lung cancer
  • Medicine composition and application thereof in preparation of medicine for treating lung cancer
  • Medicine composition and application thereof in preparation of medicine for treating lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Clinical curative effect of supplementing qi and eliminating phlegm in maintenance treatment of advanced non-small cell lung cancer

[0044] This example adopts an observational research design to analyze the curative effect of traditional Chinese medicine in the maintenance treatment of advanced NSCLC in the real world, and provides evidence-based evidence in the real world for the application of traditional Chinese medicine treatment of replenishing qi and eliminating phlegm in the maintenance treatment of advanced NSCLC.

[0045] 1. Test method

[0046] 1.1 Study Design

[0047] Observational cohort study, by STROBE criteria [4] To conduct research, analysis and reporting.

[0048] 1.2 Standards for inclusion and exclusion of research objects

[0049] Inclusion criteria:

[0050] (1) Inpatient or outpatient treatment in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from February 1, 2012 to January 31, 2019.

[00...

Embodiment 2

[0176] Example 2 The Molecular Mechanism of Yiqi Chutan Recipe Inhibiting the Progression of Lung Cancer

[0177] This example mainly carries out the following two aspects of research. First, the vein transplantation model is used to further confirm the inhibitory effect of Yiqi Chutan Recipe on metastasis, and the effect of Yiqi Chutan Recipe on cancer-associated fibroblasts is analyzed; second, multiple Cell lines clarified the mechanism of traditional Chinese medicine compound to inhibit epithelial-mesenchymal transition by regulating endoplasmic reticulum stress.

[0178] 1 material

[0179] 1.1 Experimental animals

[0180] Mice: C57BL / 6J, female, sourced from Beijing Weitong Lihua Experimental Mouse Technology Co., Ltd., 4-6 weeks old, 16-18g.

[0181] 1.2 Cell lines

[0182] LLC-hMUC1-GFP C9 was donated by Zhongke Lanhua Biotechnology Co., Ltd.

[0183] A549 cell line, non-small cell lung cancer drug-resistant cell lines H1975 and H1650 with human EGFR mutation were...

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Abstract

The invention discloses a traditional Chinese medicine composition comprising rhizoma pinellinae praeparata, stiff silkworms, ganoderma lucidum, nightshade, ternate buttercup roots, indian iphigenia bulbs, american ginseng, thunberg fritillary bulbs, glabrous sarcandra herb, barbed skullcap herb and taxus chinensis. A traditional qi-tonifying and phlegm-eliminating formula is adopted to treat lungcancer patients, the traditional Chinese medicine composition is found to have the therapeutic effect characteristic of long-term benefits when used to treat advanced non-small-cell lung cancer, theprogress-free survival (PFS) and the overall survival (OS) can be both prolonged, particularly, the traditional Chinese medicine composition has a survival smearing effect similar to immunotherapy effect characteristics in treatment, and part of patients have very long PFS; and on the other hand, the traditional Chinese medicine composition can inhibit cancer-related fibroblast activation and inhibit cancer cell metastasis, and has low side effects.

Description

technical field [0001] The invention relates to the technical field of lung cancer treatment, in particular to a pharmaceutical composition and its application in preparing medicines for treating lung cancer, and also relates to the application of the pharmaceutical composition in increasing the body weight of cancer patients. Background technique [0002] Primary lung cancer is currently the malignant tumor with the highest morbidity and mortality in the world; my country is a big country with lung cancer, and the annual incidence and death of lung cancer account for almost half of the global annual incidence [1][2] . The metastasis of lung cancer is the main reason affecting the survival of patients, and the death of 80-90% patients is caused by recurrence and metastasis. Therefore, the prevention and treatment of lung cancer metastasis is a key topic of global concern. The mechanism of metastasis is complex, involving multiple links such as epithelial-mesenchymal transi...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K36/9066A61K36/899A61P35/00A61P35/04A61P3/00A61K35/64
CPCA61K35/64A61K36/074A61K36/076A61K36/13A61K36/185A61K36/23A61K36/258A61K36/28A61K36/284A61K36/42A61K36/481A61K36/484A61K36/539A61K36/638A61K36/66A61K36/71A61K36/736A61K36/752A61K36/78A61K36/808A61K36/81A61K36/8888A61K36/8966A61K36/8968A61K36/898A61K36/899A61K36/9066A61P3/00A61P35/00A61P35/04A61K2300/00
Inventor 林丽珠孙玲玲
Owner 林丽珠