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Traditional Chinese medicine composition for treating chronic kidney disease malnutrition, and preparation and application thereof

A technology for chronic kidney disease and malnutrition, which can be used in drug combinations, medical preparations containing active ingredients, and medical raw materials derived from leeches/helminths. It can solve the problems of high price, poor compliance, and lack of clinical research results. Achieve the effect of improving clinical symptoms, improving PEW status, and improving quality of life

Active Publication Date: 2020-05-01
ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many nutritional preparations are expensive and have poor compliance, which limits clinical use; some anti-inflammatory preparations such as IL-1 receptor antagonists and TNF-α receptor blockers are in the active experimental exploration stage; promote the synthesis of Metabolized substances such as recombinant growth hormone, megestrol, androgen, etc., have application prospects, but side effects are not uncommon, and there is a lack of large-scale clinical research results

Method used

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  • Traditional Chinese medicine composition for treating chronic kidney disease malnutrition, and preparation and application thereof
  • Traditional Chinese medicine composition for treating chronic kidney disease malnutrition, and preparation and application thereof
  • Traditional Chinese medicine composition for treating chronic kidney disease malnutrition, and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Recipe for Reinforcing Qi, Strengthening the Spleen, Dispelling Blood Stasis and Leaving Turbidity

[0029] 1. Formula: 30 parts of Radix Astragali, 12 parts of Achyranthes Radix, 12 parts of Peach Kernel, 12 parts of Earthworm, 10 parts of Zhijun, 20 parts of Plantain, 15 parts of Codonopsis, 15 parts of Poria, and 15 parts of Atractylodes macrocephala.

[0030] 2. Preparation method:

[0031] According to the formula quantity, weigh 30g of Astragalus membranaceus, 12g of Achyranthes bidentata, 12g of peach kernel, 12g of earthworm, 10g of Zhijun, 20g of plantain, 15g of Codonopsis pilosula, 15g of poria cocos, 15g of Atractylodes macrocephala, add 1000ml of tap water, soak at room temperature for 30min, initially Decoct with strong fire, after boiling, change to slow fire and continue to decoct for 30 minutes, filter, take juice, and get this prescription after the liquid is cooled.

Embodiment 2

[0032] Example 2: Recipe for replenishing qi, invigorating the spleen, eliminating blood stasis and letting out turbidity

[0033] Recipe: 40 parts of Astragalus, 20 parts of Sichuan Achyranthes bidentata, 15 parts of peach kernel, 15 parts of Dilong, 15 parts of Zhijun, 10 parts of plantain, 20 parts of Codonopsis pilosula, 12 parts of Poria cocos, 10 parts of Atractylodes macrocephala. The preparation method is the same as in Example 1, and the amount of water added is 7ml / g based on the total amount of the formula.

Embodiment 3

[0034] Example 3: Recipe for replenishing qi, invigorating the spleen, eliminating blood stasis and letting out turbidity

[0035] Recipe: 50 parts of Astragalus, 15 parts of Sichuan Achyranthes, 10 parts of peach kernel, 10 parts of Dilong, 5 parts of Zhijun, 30 parts of Plantain, 10 parts of Codonopsis, 20 parts of Poria cocos, and 20 parts of Atractylodes macrocephala. The preparation method is the same as in Example 1, and the amount of water added is 7ml / g based on the total amount of the formula.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic kidney disease malnutrition, and preparation and application thereof. The composition is prepared from, by weight, 30-60 parts of radix astragali, 10-20 parts of medicinal cyathula roots, 10-15 parts of peach seeds, 5-15 parts of earthworms, 3-15 parts of prepared rhubarb root and rhizome, 10-30 parts of plantain herbs, 10-30 parts of radix codonopsis, 10-20 parts of poria cocos and 10-20 parts of largehead atractylodes rhizome. The composition can enhance serum IGF-1, Alb and PAB levels and anthropometricindicators (BMI and MAMC) and reduce blood Scr, BUN and traditional Chinese medicine syndrome points; and the composition has more advantages in improving the PEW states of CKD3-5 stage patients, so that present clinical demands can be met, improvement on the clinical symptoms of the patients can be achieved, and the purpose of enhancing the life quality of the patients can be realized.

Description

[0001] (1) Technical field [0002] The invention relates to a traditional Chinese medicine composition for treating chronic kidney disease malnutrition, a preparation method and application thereof. [0003] (2) Background technology [0004] In recent years, the prevalence of chronic kidney disease (chronic renal disease, CKD) has gradually increased. According to the survey, the prevalence of chronic kidney disease in my country has reached 10.8%. Most patients will eventually progress to a state of renal failure and protein malnutrition, the incidence rate of which can be as high as 22.7%. This is a special consumption state of chronic kidney disease. Correction, that is, protein-energy wasting state (protein–energywasting, PEW), patients often appear anorexia, fatigue, nausea and vomiting, weight loss, muscle atrophy, nail rot and other symptoms of malnutrition. Studies have found that PEW in chronic kidney disease seriously endangers the quality of life of patients and i...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61P13/12A61P1/14A61P3/02A61K35/62
CPCA61K36/481A61K36/21A61K36/736A61K35/62A61K36/708A61K36/68A61K36/344A61K36/076A61K36/284A61P13/12A61P1/14A61P3/02A61K2236/331A61K2300/00
Inventor 鲁科达郑霖张冰冰夏虹貟修远
Owner ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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