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A traditional Chinese medicine composition for treating chronic kidney disease malnutrition and its preparation and application

A technology for chronic kidney disease and malnutrition, which can be used in drug combinations, medical preparations containing active ingredients, and medical raw materials derived from leeches/helminths. It can solve the lack of clinical research results, limited clinical use, and rare side effects. To achieve the effect of enhancing cytotoxicity, enhancing immunity, and improving PEW status

Active Publication Date: 2022-01-07
ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many nutritional preparations are expensive and have poor compliance, which limits clinical use; some anti-inflammatory preparations such as IL-1 receptor antagonists and TNF-α receptor blockers are in the active experimental exploration stage; promote the synthesis of Metabolized substances such as recombinant growth hormone, megestrol, androgen, etc., have application prospects, but side effects are not uncommon, and there is a lack of large-scale clinical research results

Method used

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  • A traditional Chinese medicine composition for treating chronic kidney disease malnutrition and its preparation and application
  • A traditional Chinese medicine composition for treating chronic kidney disease malnutrition and its preparation and application
  • A traditional Chinese medicine composition for treating chronic kidney disease malnutrition and its preparation and application

Examples

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Effect test

Embodiment 1

[0024] Example 1: Recipe for Reinforcing Qi, Strengthening the Spleen, Dispelling Blood Stasis and Leaving Turbidity

[0025] 1. Formula: 30 parts of Radix Astragali, 12 parts of Achyranthes Radix, 12 parts of peach kernel, 12 parts of Dilong, 10 parts of Zhijun, 20 parts of Plantain, 15 parts of Codonopsis, 15 parts of Poria cocos, and 15 parts of Atractylodes macrocephala.

[0026] 2. Preparation method:

[0027] According to the formula quantity, weigh 30g of Astragalus membranaceus, 12g of Achyranthes bidentata, 12g of peach kernel, 12g of earthworm, 10g of Zhijun, 20g of plantain, 15g of Codonopsis pilosula, 15g of Poria cocos, 15g of Atractylodes macrocephala, add 1000ml of tap water, soak at room temperature for 30min, initially Decoct with strong fire, after boiling, change to slow fire and continue to decoct for 30 minutes, filter, take juice, and get this prescription after the liquid is cooled.

Embodiment 2

[0028] Example 2: Recipe for replenishing qi, invigorating the spleen, eliminating blood stasis and letting out turbidity

[0029] Recipe: 40 parts of Astragalus, 20 parts of Sichuan Achyranthes bidentata, 15 parts of peach kernel, 15 parts of Dilong, 15 parts of Zhijun, 10 parts of plantain, 20 parts of Codonopsis pilosula, 12 parts of Poria cocos, 10 parts of Atractylodes macrocephala. The preparation method is the same as in Example 1, and the amount of water added is 7ml / g based on the total amount of the formula.

Embodiment 3

[0030] Example 3: Recipe for replenishing qi, invigorating the spleen, eliminating blood stasis and letting out turbidity

[0031]Recipe: 50 parts of Astragalus, 15 parts of Sichuan Achyranthes, 10 parts of peach kernel, 10 parts of Dilong, 5 parts of Zhijun, 30 parts of Plantain, 10 parts of Codonopsis, 20 parts of Poria cocos, and 20 parts of Atractylodes macrocephala. The preparation method is the same as in Example 1, and the amount of water added is 7ml / g based on the total amount of the formula.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic kidney disease malnutrition and its preparation and application. The traditional Chinese medicine composition is made of the following Chinese medicine raw materials in parts by weight: 30-60 parts of astragalus, 10-20 parts of Achyranthes bidentata 10-15 parts of peach kernel, 5-15 parts of earthworm, 3-15 parts of Zhijun, 10-30 parts of plantain, 10-30 parts of Codonopsis pilosula, 10-20 parts of Poria cocos, 10-20 parts of Atractylodes macrocephala. This formula can improve serum IGF-1, Alb, PAB levels and anthropometric indicators (BMI, MAMC), reduce blood Scr, BUN and TCM syndrome scores, and has more advantages in improving the PEW status of patients with CKD stage 3-5, and can meet The current clinical demand is to achieve the purpose of improving the clinical symptoms of patients and improving the quality of life of patients.

Description

(1) Technical field [0001] The invention relates to a traditional Chinese medicine composition for treating chronic kidney disease malnutrition, a preparation method and application thereof. (2) Background technology [0002] In recent years, the prevalence of chronic kidney disease (chronic renal disease, CKD) has gradually increased. According to the survey, the prevalence of chronic kidney disease in my country has reached 10.8%. Most patients will eventually progress to a state of renal failure and protein malnutrition, the incidence rate of which can be as high as 22.7%. This is a special consumption state of chronic kidney disease. Correction, that is, protein-energy wasting state (protein–energywasting, PEW), patients often appear anorexia, fatigue, nausea and vomiting, weight loss, muscle atrophy, nail rot and other symptoms of malnutrition. Studies have found that PEW in chronic kidney disease seriously endangers the quality of life of patients and is closely relat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61P13/12A61P1/14A61P3/02A61K35/62
CPCA61K36/481A61K36/21A61K36/736A61K35/62A61K36/708A61K36/68A61K36/344A61K36/076A61K36/284A61P13/12A61P1/14A61P3/02A61K2236/331A61K2300/00
Inventor 鲁科达郑霖张冰冰夏虹貟修远
Owner ZHEJIANG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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