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Construction Method and Application of GC-MS Fingerprint of Ferula Volatile Oil

A volatile oil and anti-tumor technology, applied in the construction of GC-MS fingerprint of ferulic volatile oil and its application field, can solve the problems of less research on the chemical constituents and pharmacological effects of Junggar ferulic acid.

Active Publication Date: 2022-04-01
新疆医科大学第四附属医院
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  • Abstract
  • Description
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Problems solved by technology

However, after reviewing the literature, it is found that there are few studies on the chemical constituents and pharmacological effects of Junggar Ferulicum

Method used

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  • Construction Method and Application of GC-MS Fingerprint of Ferula Volatile Oil

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Embodiment 1

[0034] 1. Experimental materials

[0035] 1.1 Cell lines: human gastric cancer SGC-7901, human umbilical vein endothelial cells (HUVECs), purchased from the Institute of Cells, Chinese Academy of Sciences, Shanghai, cells of passage 3-5 were used in the experiments.

[0036] 1.2 Medicinal materials: identified as Ferulasinkiangensis, Ferula ferulaeoides, and Ferula songoriea by the chief Chinese pharmacist of the Affiliated Hospital of Xinjiang Medical University.

[0037] 1.3 Reagents: Endothelial cell ECM-2 medium (Scien Cell, USA); fetal bovine serum (FBS) (Hyclone, USA, batch number F160123); phosphate buffered saline (PBS) (Hyclone, USA, batch number AC10257442); RPMI- 1640 medium (U.S. Gibco Company, batch number AD16192263); dimethyl sulfoxide (DMSO) (U.S. Sigma Company, batch No. 67685TT); penicillin / streptomycin solution (U.S. Hyclone Company, batch No. J170016); MTT (U.S. Sigma Company, batch No. J170016); Batch No. EZ2811D347); with Matrigel Transwell chamber (Amer...

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Abstract

The invention provides the application of ferulic volatile oil in preparing medicines for anti-tumor angiogenesis, anti-tumor cell proliferation or anti-tumor cell invasion and migration. The invention also provides a method for constructing the GC-MC fingerprint of ferulic volatile oil. According to the experimental research, the present invention finds that the volatile oil of feruja can effectively inhibit angiogenesis and the tube-forming ability of endothelial cells; it can inhibit the proliferation, migration and invasion of tumor cells; In the experiment, the volatile oil of Junggar aweisui has the best effect.

Description

technical field [0001] The invention relates to a method for constructing GC-MS fingerprints of ferulicum volatile oil and its application, especially the application in the preparation of drugs for anti-tumor angiogenesis, anti-tumor cell proliferation or anti-tumor cell invasion and migration. Background technique [0002] Junggar ferula (Ferula songoriea Pall) is a plant of the genus Ferula in the family Umbelliferae, and its medicinal parts are root and oil gum resin. In Kazakhstan and other folks, it is used to treat headaches, colds, stomach problems and other diseases, and it is widely distributed in Altay, Tacheng and other places in Xinjiang. [0003] The medicinal ferulae included in the "Chinese Pharmacopoeia" (2015 edition) is the resin of Ferulasinkiangensis K.M.Shen or Ferula fukanensis K.M.Shen of Umbelliferae. It tastes bitter, pungent, warm, and Spleen and Stomach Meridian. It has the effects of digesting food, transforming disease, dispelling lumps and ki...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A61P35/00A61P35/04G01N30/02G01N30/72
CPCA61K36/23A61P35/00A61P35/04G01N30/02G01N30/72
Inventor 赵生俊张海英卢军张柏生范芳芳陈良轩辕欢张彦
Owner 新疆医科大学第四附属医院
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