Application of duck-derived innate immunomodulatory protein DDX3X

A technology of innate immunity and regulation of proteins, applied in the fields of biotechnology and immunology, can solve the problems of innate immune response, the expression of ISG downstream of interferon in the signal transduction process and the regulation mechanism is not very clear, and achieve the effect of reducing activity.
CN111110828APending Publication Date: 2020-05-08INST OF ANIMAL SCI & VETERINARY HUBEI ACADEMY OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF ANIMAL SCI & VETERINARY HUBEI ACADEMY OF AGRI SCI
Publication Date
2020-05-08

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Abstract

The invention belongs to the field of biotechnology and immunology, and particularly relates to a duck-derived innate immunomodulatory protein DDX3X for regulating and controlling an innate immune signal pathway in duck embryo fibroblasts (DEF), participating in antiviral reaction and playing a role in duck antiviral infection. It is proved in the DEF that overexpression of duck-derived DDX3X caninduce generation of duck I-type interferon by activating transcription factors including IRF1 and Nf-kappa B; after the background expression of DDX3X is interfered, the activity of poly(I: C) and DTMUV induced I-type interferon is also obviously reduced; and the overexpression of DDX3X can be used for remarkably inhibiting the proliferation of the DTMUV (Duck tembusu virus). The invention further discloses that the duck-derived DDX3X is expected to become a novel target for treating duck inflammatory diseases, and can be applied to the preparation of drugs with the effect of inhibiting DTMUVproliferation; the duck-derived DDX3X can also be used as an immunomodulator for duck virus diseases.
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Description

technical field

[0001] The invention belongs to the fields of biotechnology and immunology, and in particular relates to the application of duck-derived natural immunoregulatory protein DDX3X. Background technique

[0002] Duck is an important economic animal in my country, and the number of ducks raised in my country ranks first in the world. However, compared with other mammals, the research on its natural immune system started relatively late. Studies have shown that poultry's natural immune system is specific, for example, ducks have an intact RIG-I receptor, which has never given it an advantage in fighting viral infections over chickens without RIG-I receptors.

[0003] The antiviral response mediated by intracellular antiviral factors is the host's first line of defense against viral infection. Pattern recognition receptors (PRRs) are the first to recognize pathogen-associated molecular patterns (PAMPs) and initiate the host's immune response. natural immune respons...

Claims

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