Preparation method of 2-amino-5-chlorobenzotrifluoride

A technology of chlorotrifluorotoluene and a manufacturing method, which is applied to the preparation of amino compounds, the preparation of nitro compounds, chemical instruments and methods, etc., can solve the problems of time-consuming, low production efficiency of the manufacturing process, environmental pollution, etc., and achieves high production efficiency. Effect

Inactive Publication Date: 2020-05-08
JIANGSU YONGCHUANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current manufacturing process is inefficient, time-consuming and easily leads to environmental pollution problems

Method used

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  • Preparation method of 2-amino-5-chlorobenzotrifluoride
  • Preparation method of 2-amino-5-chlorobenzotrifluoride

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Such as figure 1 Shown, a kind of manufacture method of 2-amino-5-chlorobenzotrifluoride comprises the following steps:

[0025] In the first step, m-chlorobenzotrifluoride, sulfuric acid and nitric acid are mixed together for nitration reaction; the molar ratio of m-chlorobenzotrifluoride, sulfuric acid and nitric acid is 2:2:5; the reaction temperature is 110°C, and the reaction pressure is 2Mpa ;

[0026] In the second step, the mixture after the nitration in the first step is separated, the reaction mixture is collected, and the waste acid is removed at the same time;

[0027] In the third step, adding soda ash and water to the reaction mixture collected in the second step for neutralization;

[0028] In the fourth step, the neutralized mixture in the third step is added to ethanol for recrystallization;

[0029] The fifth step is to dry the recrystallized mixture in the fourth step; the drying temperature is: 50°C;

[0030] In the sixth step, hydrogen and catal...

Embodiment 2

[0037] A kind of manufacture method of 2-amino-5-chlorobenzotrifluoride, comprises the following steps:

[0038] In the first step, m-chlorobenzotrifluoride, sulfuric acid and nitric acid are mixed together for nitration reaction; the molar ratio of m-chlorobenzotrifluoride, sulfuric acid and nitric acid is 3:4:7; the reaction temperature is 150°C, and the reaction pressure is 0.5 MPa;

[0039] In the second step, the mixture after the nitration in the first step is separated, the reaction mixture is collected, and the waste acid is removed at the same time;

[0040] In the third step, adding soda ash and water to the reaction mixture collected in the second step for neutralization;

[0041] In the fourth step, the neutralized mixture in the third step is added to ethanol for recrystallization;

[0042] The fifth step is to dry the recrystallized mixture in the fourth step; the drying temperature is: 70°C;

[0043] In the sixth step, hydrogen and catalyst are added to the d...

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Abstract

The invention discloses a preparation method of 2-amino-5-chlorobenzotrifluoride, and belongs to the technical field of compound synthesis, and the preparation method comprises the following steps: 1,mixing m-chlorobenzotrifluoride, sulfuric acid and nitric acid together for nitration reaction; 2, separating the nitrified mixture in the step 1, collecting a reaction mixture, and removing waste acid at the same time; 3, adding sodium carbonate and water into the reaction mixture collected in the step 2 for neutralization; 4, adding ethanol into the neutralized mixture obtained in the step 3 for recrystallization; 5, drying the mixture recrystallized in the step 4; 6, adding hydrogen and a catalyst into the mixture dried in the fifth step for reduction; 7, carrying out reduced pressure distillation on the mixture reduced in the step 6 to obtain the finished product; 8, packaging the finished product obtained in the step 7. The method has the beneficial effects that the production efficiency is high, and environmental pollution cannot be caused after intermediate products are converted.

Description

technical field [0001] The invention relates to the technical field of compound synthesis, in particular to a production method of 2-amino-5-chlorobenzotrifluoride. Background technique [0002] 5-Chloro-2-aminotrifluoromethane, also known as 4-chloro-2-trifluoromethylaniline, is a chemical intermediate with a molecular formula of C7H6ClFO2S. The current manufacturing process is inefficient, time-consuming and prone to environmental pollution. Contents of the invention [0003] The purpose of the present invention is to provide a new manufacturing method of 2-amino-5-chlorobenzotrifluoride, the method has high production efficiency, and the intermediate product will not cause environmental pollution after conversion. [0004] In order to achieve the above object, the present invention adopts the following technical solutions: [0005] A kind of manufacture method of 2-amino-5-chlorobenzotrifluoride, comprises the following steps: [0006] In the first step, m-chlorobenz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C209/36C07C211/52
CPCC07C201/08C07C209/365C07C211/52C07C205/12
Inventor 杨桦孙德明罗汇吴德文
Owner JIANGSU YONGCHUANG PHARMA TECH CO LTD
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