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Preparation method and application of tri(2-methyl-2-phenylpropyl)tin 3, 5-dimethoxybenzoate complex

A technology of dimethoxybenzoate and dimethoxybenzoic acid, applied in the field of tritin 3,5-dimethoxybenzoate complexes, can solve application limitations, no anticancer activity, The problem of high and low anti-cancer activity is to achieve the effect of simple preparation method, low cost and high anti-cancer activity.

Inactive Publication Date: 2020-05-08
HENGYANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing studies have shown that the hydrocarbon group R in organotin carboxylates is the main factor determining the anticancer activity of the compound. For example, cyclohexyl, n-butyl and phenyltin compounds have stronger anticancer activities, followed by ethyl , the methyl group has almost no anticancer activity, and, because the known organotin compounds generally have strong toxicity, they are limited in application.

Method used

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  • Preparation method and application of tri(2-methyl-2-phenylpropyl)tin 3, 5-dimethoxybenzoate complex
  • Preparation method and application of tri(2-methyl-2-phenylpropyl)tin 3, 5-dimethoxybenzoate complex
  • Preparation method and application of tri(2-methyl-2-phenylpropyl)tin 3, 5-dimethoxybenzoate complex

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Preparation of tris(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate complex:

[0033] Add 1.0536 g (1 mmol) of bis[tris(2-methyl-2-phenylpropyl)]tin oxide and 0.3649 g (2 mmol) of 3,5-dimethoxybenzoic acid into the microwave reaction tank in sequence , The solvent was anhydrous methanol 10 mL, under the air atmosphere, the microwave reaction was carried out at a radiation power of 800 W and a temperature of 100 °C for 60 min. After the reaction, cool naturally, filter, and the solvent volatilizes and crystallizes naturally at room temperature to obtain beige crystals, which are tris(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate Complexes. Yield: 77%, melting point: 72-74 °C.

[0034] Elemental analysis (C 39 h 48 o 4 Sn): theoretical value: C, 66.96; H, 6.92. Found: C, 66.92; H, 6.95.

[0035] IR(KBr, v / cm -1): 3010.88(w), 2962.66(s), 2899.01(m), 1645.28(s), 1597.06(s), 1494.83(m), 1462.04(m), 1450.47(m), 1427.32(m), 1350.17(s ),1317.38(m), 1274.95(m), 12...

Embodiment 2

[0040] Preparation of tris(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate complex:

[0041] Add bis[tris(2-methyl-2-phenylpropyl)]tin oxide 1.0534 g (1 mmol) and 3,5-dimethoxybenzoic acid 0.3829 g (2.1 mmol) sequentially into the microwave reaction tank 1. The solvent was 15 mL of anhydrous methanol. Under air atmosphere, the microwave reaction was carried out at a radiation power of 800 W and a temperature of 100 °C for 60 min. After the reaction, cool naturally, filter, and the solvent volatilizes and crystallizes naturally at room temperature to obtain beige crystals, which are tris(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate Complexes. Yield: 78%, melting point: 72-74 °C.

[0042] Elemental analysis (C 39 h 48 o 4 Sn): theoretical value: C, 66.96; H, 6.92. Found: C, 66.92; H, 6.95.

[0043] IR(KBr, v / cm -1 ): 3010.88(w), 2962.66(s), 2899.01(m), 1645.28(s), 1597.06(s), 1494.83(m), 1462.04(m), 1450.47(m), 1427.32(m), 1350.17(s ),1317.38(m), 1274.95(m), 1201...

Embodiment 3

[0048] Preparation of tris(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate complex:

[0049] Add bis[tris(2-methyl-2-phenylpropyl)]tin oxide 1.0537 g (1 mmol) and 3,5-dimethoxybenzoic acid 0.3653 g (2 mmol) sequentially into the microwave reaction tank 1. The solvent was 12 mL of anhydrous methanol. In an air atmosphere, the microwave reaction was carried out at a radiation power of 800 W and a temperature of 100 °C for 120 min. After the reaction, cool naturally, filter, and the solvent volatilizes and crystallizes naturally at room temperature to obtain beige crystals, which are tris(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate Complexes. Yield: 79%, melting point: 72-74°C.

[0050] Elemental analysis (C 39 h 48 o 4 Sn): theoretical value: C, 66.96; H, 6.92. Found: C, 66.92; H, 6.95.

[0051] IR(KBr, v / cm -1 ): 3010.88(w), 2962.66(s), 2899.01(m), 1645.28(s), 1597.06(s), 1494.83(m), 1462.04(m), 1450.47(m), 1427.32(m), 1350.17(s ),1317.38(m), 1274.95(m), 1201.6...

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Abstract

The invention discloses a preparation method and an application of a tri(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate complex. The tri(2-methyl-2-phenylpropyl)tin 3, 5-dimethoxybenzoate complex is a complex represented by structural formula (I) shown in the description. The invention further discloses the preparation method of the tri(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate complexand the application of the tri(2-methyl-2-phenylpropyl)tin 3, 5-dimethoxybenzoate complex in the preparation of antitumor drugs.

Description

technical field [0001] The invention relates to a tris(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate complex, a preparation method thereof, and the use of the complex in the preparation of antitumor drugs Applications. Background technique [0002] Organotin carboxylates have high biological activity, and have broad application prospects in the fields of sterilization, insecticide, and anticancer drug preparation. Therefore, research on the synthesis, structure and biological activity of organotin carboxylate complexes has been sought by scientists. extensive attention. Existing studies have shown that the hydrocarbon group R in organotin carboxylates is the main factor determining the anticancer activity of the compound. For example, cyclohexyl, n-butyl and phenyltin compounds have stronger anticancer activities, followed by ethyl , the methyl group has almost no anticancer activity, and, because the known organotin compounds generally have strong toxicity, they are l...

Claims

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Application Information

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IPC IPC(8): C07F7/22A61P35/00
CPCC07F7/2224A61P35/00
Inventor 张复兴朱小明冯泳兰谭宇星庾江喜蒋伍玖邝代治
Owner HENGYANG NORMAL UNIV
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