34 results about "Methoxybenzoates" patented technology

The invention discloses a method for preparing N-(3,5-dichloropyridyl-4-yl)-3-cyclopropylmethoxy-4-difluoromethoxybenzoyl amine, which is implemented by carrying out amidation reaction on anions of 4-amino- -3,5-dichloropyridine and 3-cyclopropylmethoxy-4-difluoro-aryl-methoxybenzoate under inert solvent neutralized alkaline conditions. The preparation method disclosed by the invention has the advantages of mild reaction conditions, fewer byproducts and simple after-treatment, and obviously lowers the synthesis cost; the purity of the refined product is at least 99.8%; and the invention is more suitable for industrial large-scale production.

The present invention relates to a kind of bornyl benzoate and its preparation method and application, its chemical structure is shown in following formula (I), and chemical name is (+)-4-methoxybornyl benzoate. The synthetic method of bornyl benzoate of the present invention is that (+)-borneol, 0.75 times of borneol quality 4-methoxybenzoic acid, 0.025 times of borneol quality p-toluenesulfonic acid are added in toluene, It was obtained by reacting at 120°C for 8 hours. The (+)-4-methoxybornyl benzoate of the present invention has low cytotoxicity and the effect of penetrating the blood-brain barrier, and can promote medicines to penetrate the blood-brain barrier.

The invention relates to a high-strength long-service-life titanium-silver backboard of a household appliance. The high-strength long-service-life titanium-silver backboard is sequentially provided with a titanium-silver white refined coating, a joining layer, a titanium-silver white pre-coating, a first passivation layer, a galvanized plate, a second passivation layer and a titanium-silver white back coating, wherein the titanium-silver white refined coating comprises polyamide resin, silver powder, silver oxide, titanium dioxide and a surfactant; the titanium-silver white back coating comprises polyester resin, aluminum powder, zinc oxide, titanium dioxide and a surfactant; and the joining layer comprises a propyne-butyl acrylate copolymer, polyethylene glycol and octyl p-methoxybenzoate. Through improving the structure and formula of the coating of the backboard of the household appliance according to the scheme, not only is the favorable bending processability of the backboard not influenced, but also the backboard has the characteristics of acid and alkaline resistance, solvent resistance and ageing resistance and can still keep relatively high coating bonding strength if being in a humid environment or under a relatively large temperature difference condition for a long term, and the coating is good in substrate adhesive force, incapable of losing the luster, free of dust accumulation on the surface and free of pulverizing, cracking or blistering phenomenon if being used for a long term.

The present invention relates to a kind of bornyl benzoate and its preparation method and application, its chemical structure is shown in following formula (I), and chemical name is (+)-2-methoxybornyl benzoate. The synthetic method of bornyl benzoate of the present invention is that (+)-borneol, 0.75 times of borneol quality 4-methoxybenzoic acid, 0.025 times of borneol quality p-toluenesulfonic acid are added in toluene, It was obtained by reacting at 120°C for 8 hours. The (+)-2-methoxybornyl benzoate of the present invention has low cytotoxicity and the effect of penetrating the blood-brain barrier, and can promote medicines to penetrate the blood-brain barrier.

The invention relates to a zafirlukast intermediate preparation process, wherein the compound is an important intermediate for preparing a leukotriene antagonist drug zafirlukast. The process comprises: carrying out a heating reaction in an inert solvent under the action of acidified montmorillonite by using methyl(5-nitro-1-tosyl-1H-indole-3-yl)acetate and methyl 3-methoxybenzoate as raw materials until the raw materials disappear, filtering to obtain 3-methoxy-4-[(5-nitro-1-tosyl-1H-indole-3-yl)methyl] methyl benzoate, and hydrolyzing the 3-methoxy-4-[(5-nitro-1-tosyl-1H-indole-3-yl)methyl]methyl benzoate under alkaline conditions to obtain the target product. According to the present invention, the new process route for synthesizing the important zafirlukast intermediate is provided,has the technical advantages of simple operation, low reaction cost, high product yield and environmental friendliness, and can meet the large-scale production demand of medical products.

The invention discloses a method for synthetizing fenflumizole and belongs to the technical field of organic chemical synthesis. The method comprises the following steps: under the action of a catalyst, reacting methyl 4-methoxybenzoate with 4-methoxyacetophenone to generate 1,3-bis(4-metoxybenzene)-1,3 diketone; reacting with tert-butyl nitrite to generate 1,2-bis(4-metoxybenzene)-1,2 diketone; and reacting with 2,4-difluorine benzaldehyde to generate 2-(2,4-difluorophenyl)-4,5-bis(methoxyphenyl)-1H-imidazole. By the adoption of the method, 1,2-diketone is prepared from 1,3-diketone, so that the use of KCN (potassium cyanide) can be avoided.

The invention provides a preparation method of methyl o-methoxybenzoate. The method comprises the following steps: preparing salicylic acid and potassium hydroxide in a molar ratio of 1:(2-2.4) into an aqueous solution and adding into a reaction device; controlling the temperature to 10-20 DEG C; introducing bromomethane in a stirring condition while performing point-plate tracking of the reaction degree; after the reaction is complete, stopping stirring and standing for layering at room temperature; separating out the potassium bromide-containing wastewater on the lower layer, and concentrating to obtain a byproduct potassium bromide; washing the upper-layer product with saturated salt solution; drying with anhydrous sodium sulfate and performing reduced-pressure distillation; and collecting the fraction at 95-110 DEG C to obtain methyl o-methoxybenzoate. According to the preparation method of methyl o-methoxybenzoate provided by the invention, the technological process is shortened, the reaction time is remarkably reduced, the generation of three wastes is reduced, the wastewater treatment difficulty is relieved, and the treatment power consumption and equipment occupation are greatly reduced.

The invention relates to the technical field of cosmetics, in particular to a method for improving compounding stability of potassium 2-hydroxy-4-methoxybenzoate and tranexamic acid. A light protecting agent is added to a potassium 2-hydroxy-4-methoxybenzoate and tranexamic acid compounding system, and the pH value of the system is controlled to 4.5-6.5. The light protecting agent is added, and the pH value of products is regulated, so that the problems that after being compounded, the potassium 2-hydroxy-4-methoxybenzoate and the tranexamic acid compound can generate the phenomenon of color changes after illumination is solved, the appearance and the color stability of products are effectively protected, and the usage amount of the potassium 2-hydroxy-4-methoxybenzoate and the usage amount of the tranexamic acid can achieve relative high dosage. The appearance and the color stability of prepared products are obviously improved. Within a long time, obvious color changes are not generated, test proves that the method is effective on delaying a photochemistry reaction due to interaction of the potassium 2-hydroxy-4-methoxybenzoate and the tranexamic acid, and the products can maintain durable stability, so that consumers can obtain good using experience.

The invention discloses a tank-exterior electrochemistry composite technique of methoxylbenzyl-ketone that relates to electrochemistry technique field. Adopt Pt filament as positive pole and stainless fin as negative pole in bi-room electrolysis tank, acetic acid-acetic acid anhydride as disslovant, kalium acetate as electrolysis support, at certain temperature, lead acetate as reactor, electrolysis with constant electricity density acquiring lead tertraacetate, add all the obtained lead tertraacetate into anethole after the electrolysing is stopped and acquiring organic product after the reaction stops, hydrolytic decomposing with sulfuric acid , extract with diethyl ether and finally obtain the product acetone p-methoxybenzoate. The left lead acetate can be recycled after processing. The productivity of above technique is 52 to 62 percent. The invention has got advantages such as simple and easy reaction material, environmental reaction process, safe operation, high productivity and low cost, is a technique of high added value.

The invention provides a preparation method of dicamba. The preparation method comprises the steps as follows: A) 3,6-dichlorosalicylic acid is salified under an alkaline condition; B) 3,6-dichlorosalicylate and halomethane are subjected to a methylation reaction under the action of a catalyst, and 3,6-dichloro-2-methyl methoxybenzoate is obtained, wherein the catalyst comprises tertiary amine andquaternary ammonium salt; C) methyl 3,6-dichloro-2-methoxybenzoate is subjected to acidification and drying, and dicamba is obtained. A compound phase transfer catalyst is adopted in the etherification process, so that salicylic acid is completely converted into dicamba methyl ester, separation of oil and water phases is realized, alkaline hydrolysis and acidification routes in the prior art arereplaced by distillation and acidification, the production process in the whole process is simple, the product quality is good and industrial production is facilitated.

The invention discloses a method for synthesizing 1-(3-ethyoxyl-4-methoxy)phenyl-2-methyl-sulfonyl ethylamine and belongs to the technical field of organic synthesis processes. The method comprises the following steps: taking 3-hydroxy-4-methoxybenzoic acid as a raw material, carrying out an esterification reaction to obtain 3-hydroxy-4-methoxybenzoate, reacting with bromoethane to obtain 3-ethyoxyl-4-methoxybenzoate, then reacting with dimethyl sulfone to obtain 1-(3-ethyoxyl-4-methoxy)phenyl-2-methyl sulfonyl ethyl ketone, and finally carrying out a reductive amination reaction with ammoniumformate, thereby obtaining the 1-(3-ethyoxyl-4-methoxy)phenyl-2-methyl-sulfonyl ethylamine.

Disclosed are a sympathetic inhibitor allowing more effective inhibition of activity of a sympathetic nerve, as well as a cosmetic composition, a food, and a sundry article containing the same. Ethyl 4-methoxybenzoate is efficacious for quieting down the activity of the sympathetic nerve. The sympathetic inhibitor, the cosmetic composition, the food and the sundry article containing the same enable more effective inhibition of the activity of the sympathetic nerve.

The invention discloses a preparation method and an application of a tri(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate complex. The tri(2-methyl-2-phenylpropyl)tin 3, 5-dimethoxybenzoate complex is a complex represented by structural formula (I) shown in the description. The invention further discloses the preparation method of the tri(2-methyl-2-phenylpropyl)tin 3,5-dimethoxybenzoate complexand the application of the tri(2-methyl-2-phenylpropyl)tin 3, 5-dimethoxybenzoate complex in the preparation of antitumor drugs.

The invention relates to the field of drugs, and particularly relates to a compound capable of inhibiting proteasomes and relieving damage of an acute inflammatory reaction to bodies. The compound has the molecular structure of 3'-methoxy benzyl-4-hydroxy-3,5-dimethoxy-benzoate, can increase the survival rate of endotoxic shock mice in in-vivo tests, and has potential new drug development value.

The invention belongs to the technical field of films, and particularly relates to a preparation method of a multifunctional light scattering film. The method comprises the steps of sequentially carrying out vacuum evaporation of 2, 7-dimethyl-3- (2, 4-dichlorophenyl) -paryzolo [1, 5-a] pyrimidine-6-formic acid, 6-chorine-2-methyl-3- (5-methoxy-2-hydroxylphenimethylamine) -4 (3H) -quinazolinone, 2-chlorine-5- (5-mercapto-4-isopropyl-4H-1, 2, 4-triazole-3-base) benzenesulfonamide, 4- acetoxy-3- Berberine methoxybenzoate on a glass plate, and preparing the multifunctional light scattering film,wherein the light transmittance of the film is 86%-91%, and the haze is 89%-93%; and the color of the multifunctional light scattering film is orange, yellow and green after irradiating white light, ultraviolet light with the wavelength of 365nm and ultraviolet light with the wavelength of 254nm for 60 seconds.

The invention relates to the field of textiles, in particular to a special self-cleaning badminton sock composite yarn and a preparation method thereof. The composite yarn comprises, by weight, 40-60parts of bamboo fibers, 10-20 parts of polyester fibers, 5-10 parts of bamboo carbon fibers, 2-6 parts of ramie fibers, 20-30 parts of nano-titanium dioxide photocatalyst micro-emulsion, 10-20 parts of methyl 3-methoxybenzoate, 200-300 parts of deionized water, 15-25 parts of tween 80, 3-9 parts of cinnamyl aldehyde and 2-8 parts of glycerin monostearate. The prepared yarn is good in tensile and abrasion resistance and soft and comfortable in hand feeling. A badminton sock prepared from the yarn can meet moisture absorption and sweat releasing requirements of athletes, the nano-titanium dioxide photocatalyst micro-emulsion is sprayed, a photocatalyst layer can be formed on the surface of the yarn, harmful organic matters adhered on the yarn can be decomposed into carbon dioxide and water under sunshine, light cleaning effect is achieved, and the yarn is easily cleaned.

The present invention discloses a preparation method for 3-bromo-4-difluoromethoxy methyl benzoate represented by a formula 3. The method comprises: mixing a compound 2, sodium chlorodifluoroacetate, an inorganic weak base and an organic solvent, and carrying out a reaction at a temperature of 85-110 DEG C to obtain the finished product, wherein a molar ratio of the compound 2 to the sodium chlorodifluoroacetate to the inorganic weak base to the organic solvent is 1.0:(1.5-2.5):(1.0-2.0):(15-25), a reaction temperature is 85-110 DEG C, the organic solvent is one or a plurality of materials selected from DMF, isopropanol and 1,4-dioxane, and the inorganic weak base is one or a plurality of materials selected from potassium carbonate, cesium carbonate and sodium carbonate. The preparation method has characteristics of high conversion rate, simple post-treatment, high product yield and high product purity, and is suitable for industrial production.