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Method for improving compounding stability of potassium 2-hydroxy-4-methoxybenzoate and tranexamic acid

A technology of potassium methoxysalicylate and tranexamic acid, applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of discoloration and poor stability of whitening products, and achieve the best use experience and long-term stability. , appearance and color stability improvement effect

Active Publication Date: 2019-06-07
上海珈凯生物股份有限公司
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  • Abstract
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Problems solved by technology

[0005] In order to overcome the poor stability of the compounding of potassium methoxysalicylate and tranexamic acid, which leads to discoloration of whitening products, the present invention provides a method for improving the compounding stability of potassium methoxysalicylate and tranexamic acid, effectively improving It ensures the stability of the appearance and color of whitening products, and can make the dosage of potassium methoxysalicylate and tranexamic acid reach a relatively high dosage, ensuring the whitening effect of whitening products

Method used

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  • Method for improving compounding stability of potassium 2-hydroxy-4-methoxybenzoate and tranexamic acid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Weigh the raw materials according to the following proportions for later use:

[0035] Phase A: 0.1g disodium EDTA, 0.2g xanthan gum, 1g glycerin, 2g butanediol, 1g plant extract composition and 80g water;

[0036] Phase B: PEG-100 stearate 1g, cetearyl alcohol 0.5g, glyceryl stearate 0.5g, C14-22 alcohol 1g, C12-20 alkyl glucoside 1g, squalane 1g, palmitic acid Ethylhexyl ester 2g and polydimethylsiloxane 3g;

[0037] Phase C: 0.04g sodium hydroxide, 0.1g preservative, 0.1g potassium methoxysalicylate, 0.1g tranexamic acid, 0.01g essence; 0.1g photoprotectant; 0.08g pH regulator; pH control of phase C at 6.5;

[0038] Among them, the photoprotectant components are: 0.01g of benzophenone-4, 0.01g of dibutyl adipate, 0.01g of diethylamine hydroxybenzoyl hexyl benzoate, 0.01g of ethylhexyl methoxycinnamate g, laureth-7 citrate 0.01g, polyglyceryl-2 dipolyhydroxystearate 0.01g, ethylhexyl triazone 0.01g, bis-ethylhexyloxyphenol methoxyphenyl triazone Oxyzine 0.01g,...

Embodiment 2

[0046] (1) Weigh the raw materials according to the following proportions for later use:

[0047]Phase A: 0.3g disodium EDTA, 1g xanthan gum, 5g glycerin, 4g butanediol, 8g plant extract composition and 60g water;

[0048] Phase B: PEG-100 stearate 3g, cetearyl alcohol 1.5g, glyceryl stearate 1g, C14-22 alcohol 5g, C12-20 alkyl glucoside 5g, squalane 5g, ethyl palmitate Hexyl ester 7g and polydimethylsiloxane 0.5g;

[0049] Phase C: 0.25g sodium hydroxide, 0.2g preservative, 1g potassium methoxysalicylate, 3g tranexamic acid, 0.2g essence; 10g photoprotectant; 15.12g pH regulator; the pH value of phase C is controlled at 4.5 ;

[0050] Among them, the photoprotectant components are: benzophenone-4 1g, dibutyl adipate 1g, diethylamino hydroxybenzoyl hexyl benzoate 1g, ethylhexyl methoxycinnamate 1g, lauryl alcohol Polyether-7 Citrate 1g, Polyglyceryl-2 Dipolyhydroxystearate 1g, Ethylhexyl Triazone 1g, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine 1g, Lauryl Glucoside 1g, 1...

Embodiment 3

[0058] (1) Weigh the raw materials according to the following proportions for later use:

[0059] Phase A: 0.2g disodium EDTA, 0.8g xanthan gum, 3g glycerin, 3g butanediol, 5g plant extract composition and 70g water;

[0060] Phase B: PEG-100 stearate 2g, cetearyl alcohol 1.0g, glyceryl stearate 0.8g, C14-22 alcohol 3g, C12-20 alkyl glucoside 3g, squalane 4g, palmitic acid Ethylhexyl ester 5g and polydimethylsiloxane 2.0g;

[0061] Phase C: 0.10g sodium hydroxide, 0.15g preservative, 0.15g potassium methoxysalicylate, 0.2g tranexamic acid, 0.1g essence; 2.3g photoprotectant; 10.065g pH regulator; pH value of phase C Control at 5.0;

[0062] Among them, the photoprotectant components are: benzophenone-4 0.05g, dibutyl adipate 0.05g, diethylamine hydroxybenzoyl hexyl benzoate 0.08g, ethylhexyl methoxycinnamate 0.02 g, Laureth-7 Citrate 0.03g, Polyglyceryl-2 Dipolyhydroxystearate 0.5g, Ethylhexyl Triazone 0.5g, Bis-Ethylhexyloxyphenol Methoxyphenyl Tris Oxyzine 0.75g, Lauryl ...

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Abstract

The invention relates to the technical field of cosmetics, in particular to a method for improving compounding stability of potassium 2-hydroxy-4-methoxybenzoate and tranexamic acid. A light protecting agent is added to a potassium 2-hydroxy-4-methoxybenzoate and tranexamic acid compounding system, and the pH value of the system is controlled to 4.5-6.5. The light protecting agent is added, and the pH value of products is regulated, so that the problems that after being compounded, the potassium 2-hydroxy-4-methoxybenzoate and the tranexamic acid compound can generate the phenomenon of color changes after illumination is solved, the appearance and the color stability of products are effectively protected, and the usage amount of the potassium 2-hydroxy-4-methoxybenzoate and the usage amount of the tranexamic acid can achieve relative high dosage. The appearance and the color stability of prepared products are obviously improved. Within a long time, obvious color changes are not generated, test proves that the method is effective on delaying a photochemistry reaction due to interaction of the potassium 2-hydroxy-4-methoxybenzoate and the tranexamic acid, and the products can maintain durable stability, so that consumers can obtain good using experience.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a method for improving the compound stability of potassium methoxysalicylate and tranexamic acid. Background technique [0002] The cosmetics market is becoming more and more mature, and women who love beauty pay more and more attention to their own image. As an important cosmetic category, whitening is favored by the majority of women and occupies a considerable share in the market. Various whitening ingredients added to whitening products are also changing with each passing day. Potassium methoxysalicylate (4MSK), as a relatively new whitening ingredient, has the effect of inhibiting melanin production and has excellent defense against pigmentation caused by ultraviolet rays Effect, its whitening effect has been recognized by consumers. However, the effect of a single whitening raw material is often not as remarkable as the combined use of two or more whitening raw materials...

Claims

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Application Information

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IPC IPC(8): A61K8/368A61K8/44A61K8/35A61K8/37A61K8/86A61K8/85A61K8/49A61K8/60A61K8/41A61K8/365A61K8/20A61K8/19A61Q19/00A61Q19/02
Inventor 刘春君谢红
Owner 上海珈凯生物股份有限公司
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