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Preparation method for oral instant granules

A technology of oral instant dissolving and instant granules, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, non-effective ingredients of polymer compounds, etc., can solve the problems of inhalation of particles into organs, respiratory tract damage, and inconvenient dosage, and achieve elimination Heavy metal poisoning, prevention and effect of heavy metal poisoning, and maintenance of drug efficacy

Inactive Publication Date: 2020-05-22
广东青云山药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, various instant drugs can quickly control the disease. In actual use, if the drug is instant-dissolved in granular form, the drug can be absorbed more quickly. However, due to the presence of drug factors, the taste and bitterness of the drug make it taste bad. It is easy to control the dosage, and it is easy to inhale the particles into the organs, causing respiratory damage

Method used

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  • Preparation method for oral instant granules

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Embodiment 1

[0023] The invention provides a preparation method of oral instant granules, comprising oral instant granules, the oral instant granules are made of outer capsules and built-in instant granules, the outer capsules are coated with sugar coating, and the outer capsules are made of edible gelatin and Made of pectin, the built-in instant granules include carrier aggregates and drug factors, the carrier aggregates are made of gum arabic, mannitol, antioxidants, sweeteners and flavors, the antioxidants are set to honey, the The sweetener is set to stevioside, the essence is set to fruit flavor, and the drug factor is set to nano powder, the preparation method of the oral instant granules, the specific steps are:

[0024] Step 1: Extract the drug essence, dissolve and elute impurities, and distill out the solid drug, crush the solid drug into nano powder as the drug factor, and set aside;

[0025] Step 2: use gum arabic, mannitol, antioxidant, sweetener and essence to prepare carrier...

Embodiment 2

[0031] The invention provides a preparation method of oral instant granules, comprising oral instant granules, the oral instant granules are made of outer capsules and built-in instant granules, the outer capsules are coated with sugar coating, and the outer capsules are made of edible gelatin and Made of pectin, the built-in instant granules include carrier aggregates and drug factors, the carrier aggregates are made of gum arabic, mannitol, antioxidants, sweeteners and flavors, the antioxidants are set to honey, the The sweetener is set to stevioside, the essence is set to fruit flavor essence, and the drug factor is set to nano powder, the preparation method of the oral instant granules, the specific operation steps are:

[0032] Step 1: Extract the drug essence, dissolve and elute impurities, and distill out the solid drug, crush the solid drug into nano powder as the drug factor, and set aside;

[0033]Step 2: use gum arabic, mannitol, antioxidant, sweetener and essence t...

Embodiment 3

[0039] The invention provides a preparation method of oral instant granules, comprising oral instant granules, the oral instant granules are made of outer capsules and built-in instant granules, the outer capsules are coated with sugar coating, and the outer capsules are made of edible gelatin and Made of pectin, the built-in instant granules include carrier aggregates and drug factors, the carrier aggregates are made of gum arabic, mannitol, antioxidants, sweeteners and flavors, the antioxidants are set to honey, the The sweetener is set to stevioside, the essence is set to fruit flavor, and the drug factor is set to nano powder, the preparation method of the oral instant granules, the specific steps are:

[0040] Step 1: Extract the drug essence, dissolve and elute impurities, and distill out the solid drug, crush the solid drug into nano powder as the drug factor, and set aside;

[0041] Step 2: use gum arabic, mannitol, antioxidant, sweetener and essence to prepare carrier...

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Abstract

The invention discloses a preparation method for oral instant granules. Each oral instant granule is prepared from an outer enveloping capsule and built-in instant granules, the outer side of the outer enveloping capsule is coated with a sugar coating, the outer enveloping capsule is prepared from edible gelatin and pectin, and the built-in instant granules include a carrier aggregate and a drug factor. According to the method, the drug factor is carried by the carrier aggregate, so that a drug is distributed uniformly, the drug taste and bitter taste can be effectively covered, the granules have a popping candy effect after being eaten, the taste and flavor are unique and interesting, and the dissolution of the granules is further accelerated; the outer enveloping capsule is loaded with the built-in instant granules, so that the storage and moisture resistance of the granules are facilitated; and the sugar coating is wrapped around the outer side of the outer enveloping capsule to improve the sealing of the drug factor, an antioxidant is also used to maintain the drug effect of the drug factor, at the same time, the sugar coating is prepared from alpha-hydroxy acid to stimulate the taste bud and increase saliva, and the granules are released to moisturize and be adhered to the drug factor, so that the hidden danger of the granules entering trachea is reduced, and drug absorption is promoted.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a preparation method of oral instant granules. Background technique [0002] Orally dissolving tablet is a new type of drug that has developed relatively rapidly in recent years. It is a tablet that can disintegrate or dissolve in the oral cavity without water. This dosage form is suitable for children and the elderly, and is also suitable for patients with mental illness, patients who cannot stand upright after surgery, and patients who have difficulty swallowing, etc., and has good application value. There are many methods for preparing oral instant tablets, which can be roughly divided into: freeze-drying, direct powder compression, and wet granulation. Among them, the manufacturing process of wet granulation and tabletting is simple, and the production cost is relatively low. It is the fastest growing among the three preparation methods. Granulation is a very i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/48A61K47/36A61K47/26A61K47/42
CPCA61K9/4825A61K9/4891A61K9/1652A61K9/1623A61K9/0056
Inventor 斯聪聪孙振蛟赵轶王罡
Owner 广东青云山药业有限公司
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