Preparation method for oral instant granules

Abstract

The invention discloses a preparation method for oral instant granules. Each oral instant granule is prepared from an outer enveloping capsule and built-in instant granules, the outer side of the outer enveloping capsule is coated with a sugar coating, the outer enveloping capsule is prepared from edible gelatin and pectin, and the built-in instant granules include a carrier aggregate and a drug factor. According to the method, the drug factor is carried by the carrier aggregate, so that a drug is distributed uniformly, the drug taste and bitter taste can be effectively covered, the granules have a popping candy effect after being eaten, the taste and flavor are unique and interesting, and the dissolution of the granules is further accelerated; the outer enveloping capsule is loaded with the built-in instant granules, so that the storage and moisture resistance of the granules are facilitated; and the sugar coating is wrapped around the outer side of the outer enveloping capsule to improve the sealing of the drug factor, an antioxidant is also used to maintain the drug effect of the drug factor, at the same time, the sugar coating is prepared from alpha-hydroxy acid to stimulate the taste bud and increase saliva, and the granules are released to moisturize and be adhered to the drug factor, so that the hidden danger of the granules entering trachea is reduced, and drug absorption is promoted.

Description

technical field

[0001] The invention relates to the technical field of medicine preparation, in particular to a preparation method of oral instant granules. Background technique

[0002] Orally dissolving tablet is a new type of drug that has developed relatively rapidly in recent years. It is a tablet that can disintegrate or dissolve in the oral cavity without water. This dosage form is suitable for children and the elderly, and is also suitable for patients with mental illness, patients who cannot stand upright after surgery, and patients who have difficulty swallowing, etc., and has good application value. There are many methods for preparing oral instant tablets, which can be roughly divided into: freeze-drying, direct powder compression, and wet granulation. Among them, the manufacturing process of wet granulation and tabletting is simple, and the production cost is relatively low. It is the fastest growing among the three preparation methods. Granulation is a very i...

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