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Process for increasing liquiritigenin content

A technology of glycyrrhizin and technology, which is applied in the technology field of increasing the content of glycyrrhizin, can solve the problems of high cost, complicated technology, unfavorable large-scale production, etc., and achieve the effect of low cost, broad application prospect and easy large-scale production

Pending Publication Date: 2020-05-29
CHENGDU VOCATIONAL COLLEGE OF AGRI SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can obtain higher purity Liquiritigenin, it needs to be separated and purified by preparative liquid chromatography column, which has high cost and complicated process, and is not conducive to large-scale production.

Method used

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  • Process for increasing liquiritigenin content
  • Process for increasing liquiritigenin content
  • Process for increasing liquiritigenin content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, the technology that the present invention improves Liquiritigen content

[0031] Take 10kg of licorice medicinal material, ultrafinely pulverize it to 300-500 mesh, sterilize at 100°C for 30 minutes, add 8g of cellulase, 6kg of sterilized distilled water, and then add 35g of Saccharomyces cerevisiae (purchased from Angel Yeast Co., Ltd.), Mix evenly, put it into a breathing bag, ferment at 25°C for 2 days, and then dry to obtain a licorice fermented product.

Embodiment 2

[0032] Embodiment 2, the technology that the present invention improves glycyrrhizin content

[0033] Take 10kg of licorice medicinal material, ultrafinely grind it to 300-500 mesh, sterilize at 100°C for 30min, add 7g of cellulase, 5.5kg of sterilized distilled water, and then add 30g of Saccharomyces cerevisiae (purchased from Angel Yeast Co., Ltd.) , mixed evenly, packed into a breathing bag, fermented at 25°C for 2 days, and then dried to obtain a licorice fermented product.

Embodiment 3

[0034] Embodiment 3, the technology that the present invention improves glycyrrhizin content

[0035] Take 10kg of licorice medicinal material, ultrafinely grind it to 300-500 mesh, sterilize at 100°C for 30min, add 9g of cellulase, 6.5kg of sterilized distilled water, and then add 40g of Saccharomyces cerevisiae (purchased from Angel Yeast Co., Ltd.) , mixed evenly, packed into a breathing bag, fermented at 28°C for 3 days, and then dried to obtain a licorice fermented product.

[0036] The beneficial effects of the present invention are demonstrated through experimental examples below.

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Abstract

The invention provides a process for increasing liquiritigenin content, which takes liquorice as a raw material and is fermented by saccharomycetes. The process comprises the following steps: taking liquorice medicinal materials, sterilizing, adding cellulase, water and saccharomycetes, and fermenting. Experimental results show that the liquiritigenin content in the licorice root fermented productobtained by the fermentation process is remarkably increased, and the liquiritigenin content is increased by more than 30 times after liquorice medicinal materials with the same mass are fermented bythe specific process disclosed by the invention. The fermentation process disclosed by the invention is low in cost, simple to operate and easy for large-scale production, and has a wide applicationprospect in preparation of liquorice products with high liquiritigenin content.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine extraction, and in particular relates to a process for increasing the content of glycyrrhizin. Background technique [0002] Glycyrrhiza (Glycyrrhiza) is the dry root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat., or Glycyrrhiza glabra L., a leguminous plant, and is excavated in spring and autumn. Licorice has the functions of invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasms and relieving pain, and harmonizing various medicines. Its main active chemical components include triterpenoid saponins, flavonoids and polysaccharides. Among them, flavonoids are the most important active substances in licorice, which have obvious anti-tumor, anti-ulcer, anti-inflammatory and anti-HIV effects. Flavonoids in licorice mainly include liquiritigenin and isoliquiritigenin. Among them, Liquiriti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K31/352A61K125/00
CPCA61K36/484A61K31/352A61K2236/19
Inventor 房春林吴学渊韩笑
Owner CHENGDU VOCATIONAL COLLEGE OF AGRI SCI & TECH
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