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Surface cation functionalized graphene oxide material as well as preparation and application thereof

A graphene and functionalization technology, applied in the field of surface cationic functionalized graphene oxide material and its preparation, can solve the problem of non-enrichment of phosphorylated protein

Active Publication Date: 2020-05-29
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the surface potential of graphene oxide is negative, and it has no enrichment effect on phosphorylated proteins due to electrostatic repulsion.

Method used

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  • Surface cation functionalized graphene oxide material as well as preparation and application thereof
  • Surface cation functionalized graphene oxide material as well as preparation and application thereof
  • Surface cation functionalized graphene oxide material as well as preparation and application thereof

Examples

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Embodiment 1

[0016] 1. Preparation of surface cationic functionalized graphene oxide: press figure 1 As shown, 1) Imidazole-functionalized graphene oxide material: using the condensation reaction between the carboxyl group on the surface of the graphene oxide and the imidazole amino group, the imidazole-functionalized graphene oxide material; specifically, a 1mg / mL graphene oxide morphine ethanesulfonic acid solution , Ultrasonic for 2h to completely peel the GO to form a uniform dispersion, then add 1.05g 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and 627mg N-hydroxysuccinimide (NHS) is used as an activating reagent to activate the carboxyl group ultrasonically for 2 hours. After the activation reaction is completed, imidazole molecules with 10 times the mass of graphene oxide are added, and the reaction is stirred for 180 minutes to functionalize the graphene oxide material with imidazole. The unreacted imidazole and condensation reagent were removed by centrifugation, washed wit...

Embodiment 2

[0021] 1. Preparation of surface cationic functionalized graphene oxide: press figure 1 As shown, 1) imidazole-functionalized graphene oxide material: using the condensation reaction between the carboxyl group on the surface of the graphene oxide and the imidazole amino group, imidazole-functionalized graphene oxide material; specifically, a 2mg / mL graphene oxide morphine ethanesulfonic acid solution , Ultrasonic for 2h to completely peel the GO to form a uniform dispersion, then add 1.05g 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and 627mg N-hydroxysuccinimide (NHS) is used as an activating reagent to ultrasonically activate the carboxyl group for 2 hours. After the activation reaction is completed, imidazole molecules with 5 times the mass of graphene oxide are added, and the reaction is stirred for 120 minutes to functionalize the graphene oxide material with imidazole. The unreacted imidazole and condensation reagent were removed by centrifugation, and the deioniz...

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Abstract

The invention relates to a surface cation functionalized graphene oxide material and a preparation method thereof. The preparation method comprises the steps: preparing imidazole functionalized graphene oxide according to a condensation reaction between carboxyl on the surface of graphene oxide and imidazole molecular amino, and introducing quaternary ammonium ions through a reaction between imidazole functionalized graphene oxide and quaternary ammonium ions to obtain the surface cation functionalized graphene oxide material.

Description

Technical field [0001] The invention relates to a surface cation functionalized graphene oxide material and a preparation method thereof, belonging to the category of functional graphene oxide material preparation. The reaction process involves the condensation reaction between the carboxyl group on the surface of the graphene oxide and the amino group of the imidazole molecule, and the imidazole and 3- The substitution reaction between bromopropyltrimethylammonium bromide. Background technique [0002] Since its discovery in 2004, graphene, as a new type of two-dimensional monoatomic thickness material, has become a hot spot in current research. As an important derivative of graphene, graphene oxide has received more and more extensive research in the field of biological analysis due to its excellent physical and chemical properties. Graphene oxide not only has a large specific surface area, good hydrophilicity and biocompatibility, but also contains a large number of oxygen-co...

Claims

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Application Information

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IPC IPC(8): B01J39/17C07K1/22
CPCB01J39/17C07K1/22
Inventor 张丽华江波胡晔晨杨开广梁振张玉奎
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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