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Injectable bionic repair material for temporomandibular disease and preparation method and application of injectable bionic repair material

A technology for temporomandibular joint and repair materials, which is applied in the field of injectable bionic repair materials for temporomandibular joint disc defects and its preparation, can solve the problem of limiting the application and promotion prospects of filling repair materials for temporomandibular joint disc defects, and can not meet the needs of filling. Problems such as regular defects and lack of stent shape can achieve the effects of regeneration and repair, excellent mechanical properties, and excellent mechanical properties

Pending Publication Date: 2020-06-02
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the temporomandibular joint disc defect repair materials mentioned in existing studies are gel freeze-dried scaffolds, such as chitosan-alginate freeze-dried scaffolds and chitosan-cellulose freeze-dried scaffolds, which have clinical potential. Low operability, lack of variability in the shape of the scaffold, can not meet the problem of filling irregular defects, and the preparation is cumbersome, which limits the application and promotion prospects of filling repair materials for temporomandibular joint disc defects

Method used

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  • Injectable bionic repair material for temporomandibular disease and preparation method and application of injectable bionic repair material
  • Injectable bionic repair material for temporomandibular disease and preparation method and application of injectable bionic repair material
  • Injectable bionic repair material for temporomandibular disease and preparation method and application of injectable bionic repair material

Examples

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Embodiment 1

[0061] This embodiment provides an injectable biomimetic repair material for temporomandibular joint disc defects. The biomimetic repair material includes A component and B component, wherein the A component includes I-type gelatin, Hyaluronic acid (MAHA), methacrylic anhydride-modified chondroitin sulfate (MACS) and photoinitiator; the B component includes four-arm polyglycolic acid succinimidyl ester (PEG-NHS).

[0062] The mass ratio of the type I gelatin, the methacrylic anhydride-modified chondroitin sulfate (MACS) and the methacrylic anhydride-modified hyaluronic acid (MAHA) is 5-20:1-4:4. The mass ratio of the type I gelatin to the four-arm polyglycolic acid succinimidyl ester (PEG-NHS) is 3:1. The type I gelatin is derived from fish scales. The photoinitiator is 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone. The A component and the B component in the biomimetic repair material are mixed for use.

[0063] This embodiment also provides the application of a bion...

Embodiment 2

[0066] refer to Figure 12 , the present embodiment provides a method for preparing an injectable biomimetic repair material for temporomandibular joint disc defects, the method comprising the following steps:

[0067] S1. Type I gelatin (viscosity range 2.88mPa·s~5.28mPa·s), methacrylic anhydride-modified hyaluronic acid (MAHA) and methacrylic anhydride-modified chondroitin sulfate (MACS) according to mass ratio 5~20:1~4:4 dissolved in deionized water, and adding photoinitiator (2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone), adjust the pH and fully dissolve , to obtain a composite aqueous solution, namely the A component;

[0068] S2. Dissolving four-arm polyglycolic acid succinimidyl ester (PEG-NHS) with a relative molecular weight of 20 kDa in deionized water for later use to obtain component B.

[0069] The mass ratio of the type I gelatin to the four-arm polyglycolic acid succinimidyl ester (PEG-NHS) is 3:1. The A component and the B component in the biomimetic...

Embodiment 3

[0079] This embodiment provides an injectable biomimetic repair material for temporomandibular joint disc defects. The biomimetic repair material includes A component and B component, wherein the A component includes I-type gelatin, Hyaluronic acid (MAHA), methacrylic anhydride-modified chondroitin sulfate (MACS) and photoinitiator; the B component includes four-arm polyglycolic acid succinimidyl ester (PEG-NHS). The photoinitiator is 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone.

[0080] In this example, the preparation method of the injectable bionic repair material for temporomandibular joint disc defect is as follows: type I gelatin (viscosity 2.88mPa·s) derived from fish scales, MACS, and MAHA were prepared according to the ratio of 15:1:4. Mass ratio Dissolve in deionized water, add photoinitiator I2959, adjust pH, dissolve in water bath to obtain component A; dissolve PEG-NHS in deionized water to obtain component B.

[0081] In this example, the application of...

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Abstract

The invention discloses an injectable bionic repair material for temporomandibular disease and a preparation method and application of the injectable bionic repair material. The injectable bionic repair material for temporomandibular disease comprises A components and B components, wherein the A components comprise I type gelatin, methacrylic anhydride modified hyaluronic acid(MAHA), methacrylic anhydride modified chondroitin sulfate(MACS) and a photoinitiator; and the B components comprise 4-arm PEG-succinimidyl succinate ester(PEG-NHS).The bionic repair material can construct microenvironment which is similar to disk of temporomandibular joints of human bodies, the condition that the material has predominant fluidity before being solidified can be guaranteed, and after solidification, the material has predominant mechanical properties and also has appropriate degradation time, and is broad in application range. The obtained bionic repair material adopts a dual-network mutual-penetrating structure, has excellent mechanical properties and can meet clinical application.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an injectable bionic repair material for temporomandibular joint disc defect and its preparation method and application. Background technique [0002] Temporomandibular joint disorder (temporomandibular disease) is a common disease with an incidence rate of 20-25% in the population, and the defect caused by articular disc perforation is one of the common outcomes of temporomandibular joint disorder. The current main treatment methods are hyaluronic acid injection, joint cavity washing and surgical reduction and suture. However, due to the dense structure of the extracellular matrix of the articular disc, it is difficult for the cells to crawl, and the ability of self-repair and regeneration is weak, the treatment effect is not satisfactory, and it is easy to relapse. Hydrogels are a class of hydrophilic materials with a three-dimensional structure. Due to their good...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/20A61L27/22A61L27/50A61L27/58
CPCA61L27/20A61L27/222A61L27/18A61L27/50A61L27/58A61L2400/06A61L2430/02A61L2430/06C08L5/08C08L71/02
Inventor 孙皎许晓隋佰延刘昕
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE