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Novel application of diammonium glycyrrhizinate

A technology of diammonium glycyrrhizinate and new use, applied in the field of medicine, can solve problems such as high incidence of adverse reactions, no obvious curative effect, and no relevant reports.

Inactive Publication Date: 2020-06-05
GUIZHOU MAQIKA PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, for the treatment of the new type of coronavirus pneumonia 2019-nCoV, the initial clinical treatment plan adopted by the hospital is Ai Fu Le combined with oseltamivir and Lianhua Qingwen, and then successively announced arbidol and Lopi for the treatment of HIV Navir and ritonavir are effective, and chloroquine phosphate is effective. However, when it was used later, it was confirmed that the combination of Aifule with oseltamivir and Lianhua Qingwen was the same as that of Abidol and lopinavir and ritonavir. The regimen has no obvious effect, and the incidence of adverse reactions of oseltamivir and lopinavir and ritonavir is high, and chloroquine phosphate is only effective for mild cases
[0003] Diammonium glycyrrhizinate is currently mainly used for the treatment of hepatitis virus. It is a derivative of glycyrrhizic acid. Its mechanism is to resist the inflammatory factors produced by hepatitis B virus and protect the liver. Hormones such as hydrocortisone or prednisolone have very similar chemical structures, so it is speculated that they may have a certain anti-inflammatory effect and can be used for the treatment of new coronavirus pneumonia 2019-nCoV or chronic pulmonary obstruction. Currently, this application There are no related reports yet

Method used

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  • Novel application of diammonium glycyrrhizinate
  • Novel application of diammonium glycyrrhizinate

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example 1

[0041]Case 1: Wang Moumou, Guiyang, Guizhou, male, 79 years old, was hospitalized due to hemoptysis, and the test result was "interstitial pneumonia (sterile)", hospitalized for 8 days, no improvement, poor appetite, D-dimer Severely exceeded the standard, indicating diffuse blood coagulation throughout the body. Diammonium glycyrrhizinate capsules were used, 3 times a day, 3 capsules each time, and vitamin C 0.5g. Stop all other drugs for treatment. After taking the medicine for 3 days, the hemoptysis stopped, and the cough disappeared after a week. , The sticky phlegm in the throat disappeared, stopped taking diammonium glycyrrhizinate, and continued to take vitamin C. After three months, the routine supplement of vitamin C0.1g / day, the symptoms of chronic obstructive pulmonary disease were significantly relieved.

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Abstract

The invention discloses a novel application of diammonium glycyrrhizinate, and relates to the technical field of biological medicines. The invention relates to a novel application of diammonium glycyrrhizinate, in particular to a novel application of diammonium glycyrrhizinate in preparation of medicines for treating novel coronavirus pneumonia 2019-nCoV or chronic obstructive pulmonary disease, and meanwhile, diammonium glycyrrhizinate can also be used in combination with an immunopotentiator or a medicinal antioxidant. The diammonium glycyrrhizinate can replace hormones to resist inflammatory factors to protect the lung, but has no immunosuppressive effect and osteoporosis effect of the hormones.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to the new application of diammonium glycyrrhizinate in the preparation and treatment of novel coronavirus pneumonia 2019-nCoV or chronic pulmonary obstruction. Background technique [0002] At present, for the treatment of the new type of coronavirus pneumonia 2019-nCoV, the initial clinical treatment plan adopted by the hospital is Ai Fu Le combined with oseltamivir and Lianhua Qingwen, and then successively announced arbidol and Lopi for the treatment of HIV Navir and ritonavir are effective, and chloroquine phosphate is effective. However, when it was used later, it was confirmed that the combination of Aifule with oseltamivir and Lianhua Qingwen was the same as that of Abidol and lopinavir and ritonavir. The regimen has no obvious effect, and the incidence of adverse reactions of oseltamivir and lopinavir-ritonavir is high, and chloroquine phosphate is only effective for mild ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K38/16A61K31/375A61P31/14A61P11/00
CPCA61K31/375A61K31/704A61K38/164A61P11/00A61P31/14A61K2300/00
Inventor 张涛涛
Owner GUIZHOU MAQIKA PHARMA
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