Localized spectrum method combining intermolecular single quantum coherence and Hadamard coding

Abstract

The invention discloses a localized spectrum method combining intermolecular single quantum coherence and Hadamard coding. The localized spectrum method comprises the following specific steps: (1) testing the size of a non-uniform magnetic field by testing the spectral width of a solvent peak by using a conventional one-dimensional H spectrum; (2) generating an N-order multicolor combined soft pulse, and selecting an N-order Hadamard matrix according to the spectral width of a solvent peak; (3) adding a localization module and the generated multi-color combined soft pulse on the basis of the nuclear magnetic resonance IDEAL-III sequence to form a new high-resolution localization spectrum pulse sequence HL-IDEAL-III; (4) introducing a designed high-resolution localized spectrum pulse sequence HL-IDEAL-III into a nuclear magnetic resonance spectrometer; (3) executing a high-resolution localized spectrum pulse sequence HL-IDEAL-III to excite the sample. Inter-molecular single quantum coherent signals are selected through coherent selection gradient, the localization module completes a localization function, the obtained signals are subjected to phase decoding through the N-order Hadamard matrix, n signals are obtained through decoding, translation accumulation is performed on the n signals, and a high-resolution one-dimensional nuclear magnetic resonance localization spectrum under a non-uniform magnetic field is obtained.

Description

technical field [0001] The invention relates to the field of high-resolution nuclear magnetic resonance localization spectrum detection and analysis, in particular to a localization spectrum method combining intermolecular single quantum coherence and Hardman coding Background technique [0002] High-resolution NMR localization spectroscopy is an important analytical tool, which can provide fine molecular level information, such as chemical shift, J coupling, etc., and is widely used in chemistry, biology, medicine and other fields, but high-resolution NMR localization In domain spectrum, the inhomogeneity of the magnetic field will lead to spectral line broadening and signal overlap, and the aliased NMR spectrum will affect the data analysis. Therefore, how to obtain high-resolution spectrum under an inhomogeneous magnetic field is an urgent problem to be solved. The methods used in the prior art to obtain high-resolution NMR localized spectra under inhomogeneous magnetic f...

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Problems solved by technology

[0004] The invention provides a localized spectrum method combining intermolecular single quantum coherence and Hardman coding, which is used to quickly obtain high-resolution one-dimensional nuclear magnetic resonance localized spectrum under an inhomogeneous magnetic field, which can overcome the inhomogeneous magnetic field in the prior art Influence on the spectral lines and test data of high-resolution NMR spectra

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