A kind of environment-friendly preparation method of ibuprofen impurity h

A technology for impurities and compounds, which is applied in the field of preparation of pharmaceutical impurity standards to achieve the effects of less by-products, high purity and easy purification
CN111269100BActive Publication Date: 2021-01-19深圳市祥根生物科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
深圳市祥根生物科技有限公司
Publication Date
2021-01-19

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Abstract

The invention provides an environment-friendly preparation method of an ibuprofen impurity H, and belongs to the technical field of preparation of drug impurity standard substances. The method comprises the following steps: step 1, reacting a compound shown as a formula (I) with a compound shown as a formula (II) under the catalytic action of NaOC2H5 to prepare a compound shown as a formula (III);and step 2, reacting the compound shown in the formula (III) in the presence of CH3MgBr to prepare the ibuprofen impurity H. The method has the advantages of simplicity in operation, short preparation period, few byproducts, easiness in purification, high yield and environmental friendliness; the prepared ibuprofen impurity H is high in purity and free of obvious impurity points and meets the requirements of impurity reference substances and can be used as an ibuprofen impurity H standard substance to be applied to qualitative and quantitative research and detection of the ibuprofen impurityH so as to improve the accuracy of the detection method.
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Description

technical field

[0001] The invention belongs to the technical field of preparation of drug impurity standard products, and in particular relates to an environment-friendly preparation method of ibuprofen impurity H. Background technique

[0002] Ibuprofen (Ibuprofen), the chemical name is 2-(4-isobutylphenyl)propionic acid, and its Chinese alias is Ba Nufeng. It is a non-steroidal anti-inflammatory drug widely used clinically, belonging to aryl alkanoic drugs. Ibuprofen can be used as a substitute for aspirin, and has stronger antipyretic, anti-inflammatory and analgesic effects. It is mainly used for the control of inflammation and pain in diseases such as colds, rheumatism and rheumatoid arthritis, while the side effects are much smaller than aspirin . European Pharmacopoeia, British Pharmacopoeia, American Pharmacopoeia, Pharmacopoeia, and Chinese Pharmacopoeia all record the variety of ibuprofen, and the determination of its related substances is also described in deta...

Claims

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