Composition with inhibiting effect on gastrointestinal tract spasm and biliary system spasm, aqueous solution and preparation method of composition
A technology of inhibiting action and composition, applied in the field of medicine, can solve the problems of narrow application range, inability to inhibit smooth muscle spasm, etc., and achieve the effects of good effect, long action time and time saving.
Inactive Publication Date: 2020-06-19
奥纳斯(北京)医药科技有限公司
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- Abstract
- Description
- Claims
- Application Information
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Problems solved by technology
[0003] L-menthol has antipruritic, analgesic, antiseptic, stimulating, anesthetic, cooling and anti-inflammatory effects, and can treat headache, neuralgia, itching and respiratory inflammation, atrophic rhinitis, hoarseness, etc. The applicant's previous research found that L-menthol Alcohol can be used to inhibit gastrointestinal spasms, but L-menthol alone can only inhibit gastrointestinal spasms, but cannot inhibit other smooth muscle spasms, and its application range is narrow
Method used
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Embodiment 1
[0024] The present embodiment provides a composition comprising 70g poloxamer 188 and 50gL-menthol;
[0025] The preparation method of the composition is to physically mix 70g of poloxamer 188 and 50g of L-menthol evenly.
Embodiment 2
[0027] The present embodiment provides a composition comprising 75g poloxamer 188 and 40gL-menthol;
[0028] The preparation method of the composition is to physically mix 75g of poloxamer 188 and 40g of L-menthol evenly.
Embodiment 3
[0030] The present embodiment provides a composition comprising 80g poloxamer 188 and 30gL-menthol;
[0031] The preparation method of the composition is to physically mix 80g of poloxamer 188 and 30g of L-menthol evenly.
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Abstract
The invention provides a composition with inhibiting effect on gastrointestinal tract spasm and biliary system spasm and a poloxamer-menthol premixed aqueous solution. The composition mainly comprisespoloxamer 188 and menthol in a mass ratio of (7-8): (3-5), and menthol nanoemulsion is prepared from the composition and water for injection, and the concentration of the menthol in the water for injection is 6-10 g / L; the composition and the poloxamer-menthol premixed aqueous solution provided by the invention have an inhibiting effect on spasm of gastrointestinal tracts and biliary system, theeffect is good, the preparation method of the poloxamer-menthol premixed aqueous solution is simple, and the prepared poloxamer-menthol premixed aqueous solution is high in stability.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition capable of inhibiting gastrointestinal spasm and biliary system spasm, its aqueous solution and its preparation method. Background technique [0002] Endoscope is an optical instrument, which is sent into the body from the outside through the natural cavity of the human body to check the diseases in the body. It can directly observe the inner cavity of the viscera, determine its location and range, and can take pictures, biopsy or brush. It can greatly improve the accuracy of cancer diagnosis and can be used for certain treatments. Endoscopy is widely used, such as unchecked gastric cancer, bronchoscopy for lung cancer, tracheal cancer, esophagoscopy for esophageal cancer, etc. [0003] L-menthol has antipruritic, analgesic, antiseptic, stimulating, anesthetic, cooling and anti-inflammatory effects, and can treat headache, neuralgia, itching and respira...
Claims
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IPC IPC(8): A61K31/77A61K31/045A61K9/08A61K47/69A61P1/16A61P1/06
CPCA61K31/77A61K31/045A61K9/08A61K47/6951A61P1/16A61P1/06A61K2300/00
Inventor 李苏
Owner 奥纳斯(北京)医药科技有限公司