Method for preparing carboxyl functionalized gold nano core-shell structure MOF-5

A technology of MOF-5 and carboxyl functionalization, which is applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problem that the photothermal treatment effect of gold nanoparticles cannot be well realized, and the reduction of nanoparticle Yield, cumbersome synthesis steps and other problems, to achieve the effect of increasing yield, improving universality, and good preparation repeatability

Inactive Publication Date: 2020-06-23
上海燊铭检测技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The synthesis steps are cumbersome, and the increased steps reduce the yield of nanoparticles, and the Au / MOF core-shell structure material produced, the size of gold nanoparticles is limited by the internal structure of the metal-organic framework material, and the particle size is small, so it cannot be easily synthesized. Well-realized photothermal therapeutic effects of gold nanoparticles

Method used

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  • Method for preparing carboxyl functionalized gold nano core-shell structure MOF-5

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Effect test

Embodiment 1

[0022] A method for preparing carboxyl-functionalized gold nano-core-shell MOF-5, characterized in that it comprises the following steps:

[0023] (1), prepare the reaction substrate: zinc nitrate hexahydrate Zn(NO 3 ) 2 ·6H 2 O, 1,2,4-benzenetricarboxylic acid (C 9 h 6 o 6 ), polyvinylpyrrolidone PVP, N,N dimethylformamide mixed with alcohol, chloroauric acid HAuCl 4 The reaction substrate is obtained by mixing according to a certain mass ratio; the above mass ratio is 145:30:1820-10920:60000-80000:0.5-8.

[0024] (2), the obtained reaction substrate is fully dissolved in the reaction vessel to form a transparent, uniform and stable liquid;

[0025] (3), take out a certain amount of said liquid, join in hydrothermal kettle or other container that can carry out solvothermal reaction;

[0026] (4), the above-mentioned liquid is reacted at a temperature of 100-150° C. for 1-48 hours;

[0027] (5), after the reaction finishes, cool naturally to room temperature, centrifug...

Embodiment 2

[0030] A method for preparing carboxyl-functionalized gold nano-core-shell MOF-5, characterized in that it comprises the following steps:

[0031] (1), prepare the reaction substrate: zinc nitrate hexahydrate Zn(NO 3 ) 2 ·6H 2 O, 1,2,4-benzenetricarboxylic acid (C 9 h 6 o 6 ), polyvinylpyrrolidone PVP, N,N dimethylformamide mixed with alcohol, chloroauric acid HAuCl 4 The reaction substrate is obtained by mixing according to a certain mass ratio; the above mass ratio is 145:30:5280-8940:60000-80000:0.5-8.

[0032] (2), the obtained reaction substrate is fully dissolved in the reaction vessel to form a transparent, uniform and stable liquid;

[0033] (3), take out a certain amount of said liquid, join in the hydrothermal kettle;

[0034] (4) The above liquid was reacted for 3 hours at a temperature of 140°C;

[0035] (5), after the reaction is finished, cool naturally to room temperature, centrifuge at a speed of 10000-30000r / min to obtain a gold nano-core-shell structu...

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Abstract

The invention relates to a method for preparing a carboxyl functionalized gold nano core-shell structure MOF-5, based on solvent thermal synthesis, the method comprises the following steps: adding polyvinylpyrrolidone PVP, zinc nitrate hexahydrate Zn(NO3)2.6H2O, 1, 2, 4-benzene tricarboxylic acid(C9H6O6), and a N, N-dimethylformamide/alcohol mixed solvent and chloroauric acid HAuCl4, blending andreacting in a hydrothermal kettle; forming a metal organic framework structure, decomposing chloroauric acid under a high-temperature condition to form a gold nanoparticle core, and constraining thegrowth of an MOF-5 structure by using micelles formed by PVP, thereby preparing the MOF-5 composite material with monodispersity and uniform particle size and a gold nanoparticle core-shell structure.

Description

Technical field: [0001] The present application belongs to the technical field of nanomaterial preparation, in particular, it belongs to a method for preparing carboxyl-functionalized gold nano-core-shell structure MOF-5. Background technique: [0002] Nano-gold particles have unique optical, electrical and thermal properties, and have a higher X-ray absorption coefficient. Functionalized nano-gold (Au-core-shell structure) has good biocompatibility, water solubility and stability, and can be used in Metabolized and excreted in the body, it is a very potential CT contrast agent / photoacoustic imaging diagnostic reagent. At the same time, functionalized gold nanoparticles can also be used for photothermal therapy, and as a transportation platform to load other diagnostic and therapeutic reagents. In scientific research and clinical practice, the diagnosis and treatment of multi-focus models can be realized, and the advantages in application are much stronger. on pure gold nan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L87/00C08K3/08C08G83/00B82Y30/00B82Y40/00B22F9/30B22F1/02
CPCC08K3/08C08G83/008B82Y30/00B82Y40/00B22F9/30C08K2003/0831C08K2201/011B22F2009/165B22F1/16C08L87/00
Inventor 秦湘奇杨盛兵黄凯
Owner 上海燊铭检测技术有限公司
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