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Clean separation method of p-methylsulfonylphenylserine and glycine

A technology for the separation of thiamphenylphenylserine and its separation method, which is applied in the fields of chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., and can solve the problems of efficient and simple cleaning treatment process, no generation, etc.

Inactive Publication Date: 2020-06-30
浙江迪萧科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is still no relatively efficient and simple cleaning process for this problem.

Method used

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  • Clean separation method of p-methylsulfonylphenylserine and glycine

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Experimental program
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Effect test

Embodiment 1

[0022] A method for cleaning and separating p-thymphenylphenylserine and glycine, comprising the steps of:

[0023] The composition of the raw material solution is a mixed solution containing 40% ethanol, 5% glycine, 8% p-thymphenylphenylserine, 2% polypeptide and 0.8% enzyme. Ethanol is used as a protective solution.

[0024] 1) First pass the raw material liquid through two PVDF hollow fiber ultrafiltration membranes of model SFP-2660 for filtration to remove the enzyme in the raw material liquid;

[0025] 2) Subsequently, the raw material liquid after removing the enzyme is rotated to remove the ethanol component in the raw material liquid through a rotary evaporator at 45° C.;

[0026] 3) The raw material liquid after removing ethanol enters an ultrafiltration membrane device composed of 3 PES roll-type ultrafiltration membranes with a molecular weight cut-off of 1000 to remove polypeptides in the raw material liquid;

[0027] 4) Concentrated water washing: inject the raw...

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Abstract

The invention provides a clean separation method of p-methylsulfonylphenylserine and glycine. The method comprises the steps: an enzyme is removed from a raw material solution through a hollow fiber ultrafiltration membrane; ethanol is removed by a rotary evaporation device, polypeptide is removed by a roll type ultrafiltration membrane device, while concentration separation is carried out in a nanofiltration membrane device, clear water is continuously injected into the raw material solution at the speed the same as the real-time water production flow quantity, so that the water injection amount and the water production amount are kept consistent, the transmittance of glycine and the rejection rate of p-methylsulfonylphenylserine are increased, and a better separation effect is achieved.The method provided by the invention provides a brand-new and efficient process for separation of two organic matters in a complex system, the separation process of the process is simple, convenient and efficient, addition of any medicament is not involved, and waste liquid and other pollutants are not generated.

Description

technical field [0001] The invention belongs to the field of industrial sewage treatment and relates to a method for cleaning and separating p-thymphenylphenylserine and glycine. Background technique [0002] As an important raw material in the production of florfenicol, a broad-spectrum antibacterial drug for animals, p-thiamphenicol phenylserine can be synergistically reacted with glycine to produce an important intermediate for the production of florfenicol-p-thiamphenicol Copper serine, because the current market has developed a new process that can produce p-thymphenylphenylserine and glycine at the same time, replacing the previous separate preparation process, which greatly improves the production efficiency, but due to the existence of enzymes in the preparation process, it will make the Thymphenylphenylserine and glycine react, and ethanol can be used as a protective solution to inactivate the enzyme, so how to effectively separate these two substances from the blen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C315/06C07C317/48C07C227/40C07C229/08
CPCC07C227/40C07C315/06C07C317/48C07C229/08
Inventor 丁武龙王浩宇王宇星
Owner 浙江迪萧科技有限公司