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A kind of freckle-removing composition and preparation method thereof

A composition and freckle removal technology, applied in the direction of drug combination, pharmaceutical formula, cosmetic preparation, etc.

Active Publication Date: 2021-06-01
芭芭多芦荟生物科技研究(广州)院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, no composition has been found that can simultaneously produce positive changes that can be observed with the naked eye on chloasma, hormone spots caused by hormone withdrawal, and post-inflammatory hyperpigmentation

Method used

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  • A kind of freckle-removing composition and preparation method thereof
  • A kind of freckle-removing composition and preparation method thereof
  • A kind of freckle-removing composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, the preparation of elderberry ethanol extract methyl acetate extract and n-butanol extract

[0035] Take the stems and branches of elderberry, crush them, add 70% ethanol solution, heat and reflux to extract 3 times, extract for 2 hours each time, filter, combine the extracts, remove the solvent under reduced pressure to obtain elderberry ethanol extract; extract the above elderberry ethanol The product was suspended in 4 times its volume of deionized water, extracted with equal volumes of methyl acetate and n-butanol, respectively, and the methyl acetate extract and n-butanol extract were respectively obtained after removing the solvent.

[0036] The elderberry ethanol extract was extracted with chloroform according to the above method to obtain the chloroform extract.

Embodiment 2

[0037] Embodiment two, carob germ extract

[0038]S1. Take carob germ, dry, grind into fine powder, add deionized water in an amount 6 times the weight of the fine powder, and adjust the pH to 4.8, add 2% of the weight of the fine powder with cellulase and hydrolyze at 50° C. for 1.5 h, Inactivate at 80°C, filter, and retain the filter residue;

[0039] S2. Add the filter residue into an aqueous solution containing 2% ficin and 2% polyvinylpyrrolidone, under stirring, hydrolyze at 50°C for 2 hours, inactivate at 80°C, filter, and retain the filtrate to obtain the product.

Embodiment 3

[0040] Embodiment 3, skin lightening composition 1-13 formula and parts by weight

[0041]

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PUM

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Abstract

The invention relates to a freckle-removing composition and a preparation method thereof. The composition comprises the following components in mass fractions: 10-22 parts of elderberry extract, 3-8 parts of Artemia extract and 5-12 parts of carob germ extract , the elderberry extract is composed of methyl acetate extract of elderberry alcohol extract and n-butanol extract of elderberry alcohol extract in a weight ratio of 1:0.6-1.5. Tests have proved that the freckle-removing composition provided by the invention has obvious improvement effects on chloasma, hormone spots caused by hormone withdrawal and post-inflammatory pigmentation.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a freckle removing composition and a preparation method thereof. Background technique [0002] Chloasma, which is called "Purity Dark Spot" in traditional Chinese medicine, is also called "face dust". Melasma is a yellow-brown spot that commonly occurs on the face. There are many reasons. Pregnancy, oral contraceptives, irregular menstruation, endocrine dysfunction, and chronic liver and kidney diseases can all be the cause of the disease. At present, the common drugs used to treat chloasma include arbutin. [0003] Hormone plaques refer to hormone plaques that appear in the late stage of hormone withdrawal. During hormone withdrawal, patients need to stop using hormone-containing products and switch to hormone-free products. 1 to 2 days after hormone withdrawal, the skin on the medication site occurs Significant erythema, hyperpigmentation, resulting in the formation of hor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/98A61K8/9789A61Q19/02A61P17/00
CPCA61K8/987A61K2800/591A61K2800/805A61Q19/02A61K8/9789A61P17/00
Inventor 梁以娟
Owner 芭芭多芦荟生物科技研究(广州)院