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Abamectin B2a solvate solid and preparation method thereof

A solvation technology of abamectin, applied in the field of pesticides, can solve the problems of poor stability of abamectin B2a, fast decomposition speed at room temperature, etc., and achieve the effects of low decomposition rate, convenient operation and improved stability

Active Publication Date: 2020-07-10
HEBEI VEYONG BIO CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of poor stability of existing avermectin B2a and fast decomposition speed at room temperature, the invention provides a solvated solid of abamectin B2a and a preparation method thereof

Method used

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  • Abamectin B2a solvate solid and preparation method thereof
  • Abamectin B2a solvate solid and preparation method thereof
  • Abamectin B2a solvate solid and preparation method thereof

Examples

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Effect test

Embodiment 1

[0031] A solvated solid of abamectin B2a, composed of isopropyl acetate in abamectin B2a crystal and abamectin B2a crystal structure, the mass content of isopropyl acetate in the solvated solid is 25 %, the specific preparation method is as follows:

[0032] Get 120 g of the crude product of Abamectin B2a (content 85%) and add it to a 1 L four-neck flask, add 360 g of isopropyl acetate, heat to 60° C. and stir to dissolve until clarified. Slowly lower the temperature to 0-10° C. for crystallization for 5 h, filter to obtain 110 g of abamectin B2a solvated solid containing isopropyl acetate, wherein the content of isopropyl acetate is 25% (detected by gas chromatography).

Embodiment 2

[0034] A solvated solid of abamectin B2a, composed of isopropyl acetate in abamectin B2a crystal and abamectin B2a crystal structure, the mass content of isopropyl acetate in the solvated solid is 10 %, the specific preparation method is as follows:

[0035] Get Avermectin B2a crude product (content 85%) 120g and add 1L four-necked bottle, add isopropyl acetate 360g, be heated to 60 ℃ and dissolve to clarification. Slowly cool down to 0-10°C for crystallization for 6h, filter, and dry in vacuo at 40°C for 3h to obtain 93.5g of abamectin B2a solvated solid containing isopropyl acetate, wherein the content of isopropyl acetate is 10% (by gas chromatography law detection).

Embodiment 3

[0037] A solvated solid of abamectin B2a, composed of abamectin B2a crystals and sec-butyl acetate in the crystal structure of avermectin B2a, the mass content of sec-butyl acetate in the solvated solid is 12 %, the specific preparation method is as follows:

[0038] Take 120g of crude abamectin B2a (content 85%) and add it to a 1L four-neck bottle, add 240g of sec-butyl acetate, heat to 40°C and stir for 4h until dissolved and clear, slowly cool down to 0-10°C, filter, and vacuum at 40°C After drying for 1 h, 70 g of abamectin B2a solvated solid containing sec-butyl acetate was obtained, wherein the sec-butyl acetate content was 12% (detected by gas chromatography).

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Abstract

The invention relates to the technical field of pesticides, and particularly discloses an abamectin B2a solvate solid and a preparation method thereof. A crystal structure of the abamectin B2a solvatesolid contains a small molecular organic solvent which is combined with abamectin B2a molecules through intermolecular weak interaction, wherein the mass content of the small molecular organic solvent is 10-25%, and the small molecular organic solvent is at least one of an organic solvent A or an organic solvent B, and the organic solvent A is an ester compound or a furan compound; and the organic solvent B is an ether compound or C5-C15 alkane. The abamectin B2a solvate solid provided by the invention has good stability, after storage at 40DEG C in a sealed state for 12 months, the decomposition rate is less than 5%, and the storage decomposition rate at 4DEG C is less than or equal to 0.7%, and the requirements for storage and transportation conditions of the abamectin B2a are greatly reduced.

Description

technical field [0001] The invention relates to the technical field of pesticides, in particular to a solvated solid of abamectin B2a and a preparation method thereof. Background technique [0002] Abamectin B2 includes two main components, B2a and B2b, among which, Abamectin B2a has special effects on underground nematodes and animal surface pests. The extraction and purification technology of Abamectin B2a in industrial production has achieved a qualitative leap, and it has been able to prepare the original drug of Abamectin B2a with a content of more than 90%. However, due to the poor stability of abamectin B2a, the storage decomposition rate is fast at room temperature, and it can be decomposed by more than 50% in sealed storage at room temperature for 12 months. Therefore, abamectin B2a must be stored at low temperature. Transportation brings a lot of inconvenience. [0003] At present, the original drug of Abamectin B2a still needs to be stored below minus 20°C, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/22A01N43/90
CPCA01N25/22A01N43/90
Inventor 史秀肖范立攀贾成国
Owner HEBEI VEYONG BIO CHEM
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