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Method for treating brain cancer

A technology for brain cancer and cancer, applied in the field of brain cancer treatment, can solve problems such as poor effectiveness and unmet medical needs

Inactive Publication Date: 2020-07-14
ALLIANZ PHARMASCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Effectiveness of current conventional therapies remains poor, creating an unmet medical need for GBM treatment

Method used

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  • Method for treating brain cancer
  • Method for treating brain cancer
  • Method for treating brain cancer

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0089] Example 1: Efficacy of ASC-JM17 (JM17) in an in vitro model of glioblastoma multiforme (GBM)

[0090] JM17 selectively exhibits cytotoxicity against TMZ-resistant glioblastoma

[0091] The effect of JM17 on the proliferation of GBM cells was studied in several cell lines independently derived from GBM cancer. First, well-characterized and commercially available A172 and U87MG cells were purchased from ATCC ( CELL LINES BY GENEMUTATION. 2019). Second, primary glioblastoma cells Pt#3 were derived from GBM patients by following published procedures (Chang KY (Chang KY), Xu TI (Hsu TI), Xu CC (Hsu CC) et al. Specific Protein 1 Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma independently of O(6)-methylguanine-DNA methyltransferase (Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomid resistance in glioblastoma, which is independent of O(6)-methylguanine-DNAmethyltransferase). "Redox Biol." 20...

example 2

[0098] Example 2: Efficacy of ASC-JM17 (JM17) in an Animal Model of Glioblastoma Multiforme (GBM)

[0099] JM17 inhibits the growth of glioblastoma in an orthotopic mouse model

[0100] To further investigate the in vivo tumor suppressor properties of JM17, a GBM mouse model with intracranial transplantation of luciferase-expressing U87MG cells was utilized.

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Abstract

The invention relates to a method for treating a brain cancer. The invention provides a method for treating a brain cancer in a subject in need of such treatment, comprising administrating to the individual a pharmaceutical composition comprising an effective amount of a compound having at least one (substituted phenyl)-propenal moiety and optionally a pharmaceutically acceptable carrier or excipient, which can effectively treat the brain cancer.

Description

technical field [0001] The present invention relates to a method of treatment, more specifically, the present invention provides a method of treating brain cancer with a compound having at least one (substituted phenyl)-acrolein moiety and its use. Background technique [0002] It is well known that certain natural products can have therapeutic properties, leading to their use in many cultures for the treatment and prevention of human disease (such as Chinese herbal medicine and many other folk medicines). Such therapeutic effectiveness has led the pharmaceutical industry to seek and isolate active compounds from these natural products and to develop active ingredients as therapeutic or prophylactic drugs for the treatment and prevention of various diseases or medical conditions. Accordingly, many commonly used pharmaceuticals have been developed or derived from natural products. However, compounds isolated from natural products are known to exert certain physiological func...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K31/426A61K31/5375A61K31/165A61K31/216A61K31/192A61P35/00A61P25/00A61P35/02
CPCA61K31/12A61K31/165A61K31/192A61K31/216A61K31/426A61K31/5375A61P25/00A61P35/00A61P35/02A61K31/015
Inventor 詹维康陈咨锜
Owner ALLIANZ PHARMASCI
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