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Cannabidiol and chitosan compositions and methods of using the same

A kind of technology of cannabidiol and composition, applied in the field of compositions comprising cannabidiol and chitosan

Pending Publication Date: 2020-07-14
MOR RES APPL LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But high blood cholesterol carries risk of coronary heart disease

Method used

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  • Cannabidiol and chitosan compositions and methods of using the same
  • Cannabidiol and chitosan compositions and methods of using the same
  • Cannabidiol and chitosan compositions and methods of using the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] Anti-dyslipidemic effect of chitosan-lecithin / CBD preparation in guinea pig-induced dyslipidemia model

[0124] The aim of this study was to examine blood cholesterol levels in guinea pigs fed a high-fat diet rich in lauric acid and myristic acid alone or in combination with various formulations.

[0125] Blood cholesterol and triglycerides were examined in male guinea pigs after oral administration of the various formulations relative to the control group.

[0126] Measurements of cholesterol and triglyceride levels in serum were performed after 7-10 days of exposure to the different diets.

[0127] animal

[0128] The average body weight at the start of the study was 370 g. The minimum and maximum weight in the group did not exceed ±20% of the group mean body weight.

[0129] During the acclimatization period, animals were fed ad libitum, "ad libitum" commercial guinea pig diet (Harlan Teklad Guinea Pig Diet No: 2040S).

[0130] Animals had free access to water ...

Embodiment 2

[0230] Blood cholesterol-lowering effect of chitosan-lecithin / CBD preparation in a rat model of dyslipidemia

[0231] The purpose of this study was to investigate blood cholesterol and triglycerides in male rats following oral administration in the diet of the various formulations (specified below) of the test group, with respect to the HFHS diet alone.

[0232] The primary objective was to evaluate the cholesterol-lowering effect of a CLC-enriched diet. Secondary objectives were the effect of CLC on changes in triglyceride levels and weight during the HFHS diet.

[0233] Materials and methods

[0234] preparation

[0235] High-fat, high-sugar diet:

[0236]

[0237] Test item 1:

[0238]

[0239] Medium of CBD:

[0240]

[0241] Preparations of test items:

[0242] pelleted diet

[0243] TEKLAD prepares custom diets designed to cause elevated cholesterol levels and induction of dyslipidemia in rodents. All diets were supplied to the testing facility as ready-...

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Abstract

The present invention provides a composition based on cannabidiol (CBD) and chitosan for use in reducing blood cholesterol, blood LDL and blood triglycerides levels.

Description

[0001] cross reference [0002] This application claims the benefit of priority to U.S. Provisional Patent Application No. 62 / 573,813, filed October 18, 2017. Its content is incorporated herein by reference in its entirety. technical field [0003] The present invention relates to compositions comprising cannabidiol (CBD) and chitosan for the amelioration of dyslipidemia and other signs and symptoms of metabolic syndrome, among others. Background technique [0004] Cannabidiol (CBD) - the main non-psychotropic constituent of cannabis - has anticonvulsant, anxiolytic, antipsychotic, anti-nausea and anti-rheumatoid arthritis properties. CBD does not bind to known cannabinoid receptors, and its mechanism of action is unknown. [0005] CBD was first isolated from Mexican hemp by Roger Adams and from Indian hemp resin by Alexander Todd, both in 1940. The crystal structure of CBD was determined by Jones et al. (1977). Two separate forms of CBD are proposed, the main differenc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/722A61P3/06
CPCA61K31/352A61K31/722A61P3/06A61K9/146A61K9/1652A61P3/04A61P3/10A61K47/44A61K45/06A61K31/05A61K47/36A61K9/0053A61K2300/00A61K47/10A61K47/24
Inventor N·本沙洛姆D·罗宾逊
Owner MOR RES APPL LTD