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Preparation method of double-chirality beta-CD @ Cu-MOF nano composite sensor and application thereof

A nano-composite, dual-chirality technology, applied in instruments, scientific instruments, textiles and papermaking, etc., can solve the problems of low sensor utilization and low sensitivity, and achieve good industrial prospects, high sensitivity, and simple equipment.

Inactive Publication Date: 2020-07-24
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most current electrochemical sensors usually involve only one signaling mechanism, resulting in low sensitivity and low sensor utilization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Preparation method of a bichiral β-CD@Cu-MOF nanocomposite sensor

[0028] 0.58 g of Cu (NO 3 ) 2 ·3H 2 O was mixed with 3 mL of water to obtain a copper nitrate solution;

[0029] Add 0.05 g of ligand L-aspartic acid L-Asp and 0.03 g of NaOH into 3 mL of water, and ultrasonicate at 180 W for 2 min to obtain a clear ligand solution;

[0030] Mix the copper nitrate solution and the ligand solution evenly, let stand at room temperature for 4 h, centrifuge, wash the obtained solid three times with water and ethanol respectively, and dry to constant weight at 85 °C to obtain Cu-MOF nanofibers;

[0031] 6 mg Cu-MOF nanofibers and 6 mg β-cyclodextrin β-CD were blended with 720 μL water, 250 μL ethanol and 30 μL Nafion, and ultrasonicated at 180 W for 30 min to prepare β-CD@Cu-MOF nanofibers. Take 10 μL of the fiber suspension and drop-coat it on the glassy carbon electrode GCE, and dry it overnight at room temperature to obtain the β-CD@Cu-MOF / GCE electrode, tha...

Embodiment 2

[0032] Example 2 Preparation method of a bichiral β-CD@Cu-MOF nanocomposite sensor

[0033] 0.60 g of Cu (NO 3 ) 2 ·3H 2 O was mixed with 5 mL of water to obtain a copper nitrate solution;

[0034] Add 0.055 g of ligand L-aspartic acid L-Asp and 0.035 g of NaOH into 5 mL of water, and ultrasonicate at 180 W for 3 minutes to obtain a clear ligand solution;

[0035] Mix the copper nitrate solution and the ligand solution evenly, let stand at room temperature for 5 h, and centrifuge, wash the obtained solid three times with water and ethanol, respectively, and dry it to constant weight at 85 °C to obtain Cu-MOF nanofibers;

[0036]6 mg Cu-MOF nanofibers and 6 mg β-cyclodextrin β-CD were blended with 720 μL water, 250 μL ethanol and 30 μL Nafion, and ultrasonicated at 180 W for 30 min to prepare β-CD@Cu-MOF nanofibers. Take 10 μL of the fiber suspension and drop-coat it on the glassy carbon electrode GCE, and dry it overnight at room temperature to obtain the β-CD@Cu-MOF / GCE e...

Embodiment 3

[0037] Example 3 Preparation method of a bichiral β-CD@Cu-MOF nanocomposite sensor

[0038] 0.62 g of Cu (NO 3 ) 2 ·3H 2 O was mixed with 7 mL of water to obtain a copper nitrate solution;

[0039] Add 0.06 g of ligand L-aspartic acid L-Asp and 0.04 g of NaOH into 7 mL of water, and ultrasonicate at 180 W for 4 min to obtain a clear ligand solution;

[0040] Mix the copper nitrate solution and the ligand solution evenly, let stand at room temperature for 6 h, centrifuge, wash the obtained solid three times with water and ethanol respectively, and dry to constant weight at 85 °C to obtain Cu-MOF nanofibers;

[0041] 6 mg Cu-MOF nanofibers and 6 mg β-cyclodextrin β-CD were blended with 720 μL water, 250 μL ethanol and 30 μL Nafion, and ultrasonicated at 180 W for 30 min to prepare β-CD@Cu-MOF nanofibers. Take 10 μL of the fiber suspension and drop-coat it on the glassy carbon electrode GCE, and dry it overnight at room temperature to obtain the β-CD@Cu-MOF / GCE electrode, tha...

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Abstract

The invention discloses a preparation method of a double-chirality beta-CD @ Cu-MOF nano composite sensor and application of the sensor as an electrochemical sensing tyrosine and penicillamine isomerat the same time, and belongs to the technical field of nano composite material technology, electro-catalysis technology and isomer recognition technology. The preparation method comprises the following main steps of: mixing a copper nitrate solution and a ligand solution, and standing at room temperature to prepare Cu-MOF nano fibers; and blending the Cu-MOF nano fibers and beta-cyclodextrin beta-CD, and dropwise coating a glassy carbon electrode GCE with the mixture to prepare the double-chirality beta-CD @ Cu-MOF / GCE nano composite sensor. The sensor is low in raw material cost and low inreaction energy consumption, and the preparation method is simple and efficient. The sensor is applied to electrochemical sensing of tyrosine and penicillamine isomers at the same time, has the advantages of high sensitivity, simple equipment, high electrochemical stability and the like, and has a good industrial prospect.

Description

technical field [0001] The invention discloses a preparation method of a bichiral β-CD@Cu-MOF nanocomposite sensor and the application of the sensor as simultaneous electrochemical sensing of tyrosine and penicillamine isomers, belonging to nanocomposite technology, Electrocatalytic technology and isomer recognition technology field. Background technique [0002] Cyclodextrins (CDs) are a class of cyclic oligosaccharides consisting of 6, 7 or 8 glucose units (designated α-, β- or -CD, respectively) in a ring shape with a hydrophobic inner cavity and a hydrophilic external structure. CDs are less costly and have an excellent ability to efficiently and selectively accommodate various compounds in their hydrophobic cavities, forming host-guest inclusion bodies. These properties make them significant. In fact, CDs have been widely used in the field of electroanalytical chemistry. In the application of constructing chiral sensors, several electrochemical methods based on CDs h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48D01F6/96C08G83/00
CPCC08G83/008D01F6/96G01N27/308G01N27/48
Inventor 侯莹匡轩
Owner UNIV OF JINAN
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