A drug-loaded artificial rectum for transplantation and its preparation method

Abstract

The invention relates to a drug-loaded artificial rectum for transplantation and a preparation method thereof. The artificial rectum comprises: an inner layer of an intestinal stent, which is a grid-shaped cylindrical structure prepared by using biological materials to mix and load drugs; an outer layer of the intestinal stent , is a dense cylindrical structure made of biological materials, and the outer layer of the intestinal stent is integrally formed on the outer periphery of the inner layer of the intestinal stent; thus, the inner layer of the intestinal stent and the outer layer of the intestinal stent jointly form a The intestinal tract with content flow, and the inner layer of the intestinal stent can release the loaded drug into the intestinal tract. The artificial rectum of the present invention completely imitates the real tissue of the human body, which can be applied to different disease stages and the physiological conditions of patients, and realizes that the artificial rectum can be implanted for the purpose of biomimicking the normal physiological activities of the human body, and can be used normally and ensure sealing; and, the The artificial rectum can slowly release anti-inflammatory drugs and drugs that regulate intestinal flora into the intestine, and can complete the anti-inflammatory and intestinal flora effects while replacing the original structure.

Description

technical field [0001] The invention relates to an artificial prosthesis, in particular to a drug-loaded artificial rectum for transplantation with anti-inflammatory effect and improved activity of intestinal flora and a preparation method thereof. Background technique [0002] Early middle and low rectal cancer is one of the most common malignant tumors of the digestive tract, accounting for about 75% of rectal cancer cases, and the lesion is located 3 to 9 cm away from the anal verge. At present, although local excision and anus-preserving surgery have received more and more attention, the lesion goes deep into the pelvis, the anatomical relationship is complicated, the operation is not easy to complete, and the recurrence rate after operation is high. Especially for tumors within 6cm from the anal verge, it is generally considered that radical resection must be performed to remove the entire rectum. [0003] In order to make up for the absence of the rectum, colon draggi...

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Problems solved by technology

[0004] However, the existing artificial rectum does not consider the factors of the intestinal flora and inflammatory response. The direct use of the shaped structure does not have the function of drug release, which is prone to infection and inflammation and may have a destructive effect on the original intestinal flora.

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