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A neuron probe based on carbon nanotube/conductive polymer and its preparation method

A technology of conductive polymers and carbon nanotubes, applied in separation methods, chemical instruments and methods, light guides, etc., can solve the problems of unsuitable neurite penetration and growth, high growth density of CNT arrays, and increased preparation costs, and achieve suitable Nerve cell growth, excellent electrochemical performance, and optimized tissue culture effects

Inactive Publication Date: 2016-01-20
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the preparation conditions of this method are relatively harsh, the required temperature is too high (800-1000°C), the requirements on the electrode substrate are strict, the preparation cost is greatly increased, and the growth density of the CNT array is too high, which is not suitable for the penetration and growth of neurites.

Method used

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  • A neuron probe based on carbon nanotube/conductive polymer and its preparation method
  • A neuron probe based on carbon nanotube/conductive polymer and its preparation method
  • A neuron probe based on carbon nanotube/conductive polymer and its preparation method

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Embodiment 1

[0034] A neuron probe based on carbon nanotube / conducting polymer (CNT / CP) and its preparation, including the preparation of CNT-modified probe and CP coaxially coating CNT.

[0035] The CNT three-dimensional porous network of CNT-modified probes on the surface of the substrate electrode is achieved by electrophoretic deposition of single-walled carbon nanotube (SWNT) dispersion (containing multivalent metal ions).

[0036] SWNTs were purified by mixed acid, and 60 mL of mixed acid (concentrated H 2 SO 4 : concentrated HNO 3 =3:1V / V), the mixture was sonicated in a water bath for 4h. The resulting solution was immediately diluted to 1000 mL with a large amount of deionized water, filtered with a polytetrafluoroethylene (PTFE) membrane with a pore size of 0.22 μm, and ultrasonically dispersed in 200 mL of acetone for 10 minutes to remove organic impurities contained therein and then suction filtered. Then ultrasonically disperse in 200mL of absolute ethanol, filter, wash in ...

Embodiment 2

[0043] CNT / polyaniline (PAN)-modified neuron probes were prepared in substantially the same manner as in Example 1.

[0044] Prepare 0.1MNi(NO 3 ) 2? 6H 2 O instead of Al(NO 3 ) 3? 9H 2 O Electrophoretic deposition of CNTs.

[0045] Using the prepared CNT-modified electrode as the working electrode, CP was deposited on the surface of the CNT network by electrochemical pulse polymerization in a mixed aqueous solution of 0.1M sodium p-toluenesulfonate and 0.05M aniline. The electrochemical polymerization was carried out with an electrochemical workstation, using a three-electrode system, with a CNT-coated electrode as the working electrode, Ag / AgCl as the reference electrode, and a platinum wire electrode as the counter electrode. The polymerization potential is 0.75V, and when the potential drops to 0V after 5s of polymerization, the setting is kept for 600s as a cycle (ie t on =5s,t off =600s), copolymerized 12 times, that is, 12 cycles, and the total polymerization ti...

Embodiment 3

[0049] The CNT / polypyrrole (PPy)-modified neuron probe was prepared in substantially the same manner as in Example 1. Al in the electrolyte 3+ The concentration was adjusted to 1.5mM, and other conditions remained unchanged.

[0050] Performance parameters of the prepared neuron probe based on carbon nanotube / conducting polymer (CNT / CP):

[0051] The diameter of the CNT tube bundle is about 13.0nm, the thickness of the PPy coaxial coating is about 3.3nm, and the pore diameter of the CNT / CP composite is about 60nm.

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Abstract

The invention discloses a nerve cell probe based on a CNT (Carbon Nano Tube) / conducting polymer and a preparation method thereof. The nerve cell probe with a decorative three-dimensional porous network structured CNT / conducting polymer compound on the surface is prepared according to electrophoretic deposition and electrochemical pulse polymerization methods. The preparation method comprises the following steps: firstly, adopting polyvalent metal ions for converting the electronegativity of CNT surface; depositing a CNT coating on the electrode surface of a substrate according to an electrophoretic method; preparing an aperture-controllable CNT three-dimensional network; coaxially covering CP on the surface of CNT beams according to an electrochemical pulse polymerization method, thereby forming a compound coating with a three-dimensional porous nano structure. The nerve cell probe provided by the invention has a three-dimensional porous nano networked structure on the surface and has high conductivity, excellent electrochemical property and excellent cytocompatibility. An adhesive force between a compound decorative layer on the surface of the probe and the substrate is enhanced, so that the requirement of a nerve repairing element for nano functionalization for an electrode material is met.

Description

technical field [0001] The invention belongs to the technical field of new biomaterials, and relates to a neuron probe and a preparation method thereof, in particular to a carbon nanotube (CNT) / conductive polymer (CP) neuron probe with controllable aperture and a preparation method thereof , the modified neuron probe has good electrochemical performance and excellent cell compatibility, and can be applied to the output and writing of central nervous system signals. Background technique [0002] The main function of the neuron probe is the recording of nerve action potential and signal transmission, and its performance depends on the contact and impedance between the signal recording point and the nerve tissue. Due to the small amplitude of bioelectrical signals and the high internal resistance of signal sources, the interface between neuron probes and neuron cells faces challenges in terms of signal sensitivity, biocompatibility, and long-term effectiveness. Compared with t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/04B81B1/00
Inventor 车剑飞肖迎红杨熙
Owner NANJING UNIV OF SCI & TECH