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A kind of cross-linked sodium hyaluronate composite solution preparation and its preparation method and application

A technology of cross-linking hyaluronic acid and sodium hyaluronate, which is applied in the field of implantable medical devices and skin nutrition, and can solve problems such as inapplicability, affecting appearance, and easy formation of skin nodules

Active Publication Date: 2022-04-15
IMEIK TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these cross-linked sodium hyaluronates are not suitable for superficial filling of the skin, because they have obvious graininess and are prone to form skin nodules, affecting the appearance

Method used

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  • A kind of cross-linked sodium hyaluronate composite solution preparation and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Preparation of Example 1 Crosslinked Sodium Hyaluronate Composite Solution Preparation-1

[0037] Take 10.0 g of sodium hyaluronate (with a weight average molecular weight of 1.2 million Daltons) and add it to 90.0 g of water for injection. Stir and mix well with a glass rod, and let stand at room temperature for 30 min. Add 5.0g sodium hydroxide, stir and mix with a glass rod; then add 0.2g 1,4-butanediol diglycidyl ether, react at 25°C for 16h; then add 2M hydrochloric acid 62.5mL, and add water for injection to the total weight 1000.0g. Homogenize for 30 minutes using a homogenizer (IKA's T25 digital display type, equipped with a dispersing cutter head of 18G). Transfer to a 2L Schott bottle, and sterilize with damp heat at 121°C for 15 minutes to obtain a cross-linked sodium hyaluronate solution for later use.

[0038] Weigh 60.0 g of sodium hyaluronate (weight average molecular weight of 1.2 million Daltons), 8.0 g of L-carnosine, 0.8 g of glycine, 0.8 g of alan...

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Abstract

The invention relates to a cross-linked sodium hyaluronate composite solution preparation and a preparation method and application thereof. The cross-linked sodium hyaluronate composite solution preparation includes: 1-20 mg / mL of cross-linked sodium hyaluronate; 0.1-20 mg / mL of water-soluble non-cross-linked polymer polysaccharide or its salt form; 0-20 mg / mL of polypeptide; Amino acid 0~10mg / mL; Vitamin 0~50μg / mL. Compared with common cross-linked sodium hyaluronate filling materials, the cross-linked sodium hyaluronate composite solution preparation of the present invention has lower viscosity and better fluidity; compared with non-cross-linked sodium hyaluronate, the degradation time is longer . The product of the present invention is used by intradermal injection, and can be used for correcting human body wrinkles such as facial wrinkles, eye wrinkles, forehead lines, neck lines, hand wrinkles, and stretch marks.

Description

technical field [0001] The invention belongs to the fields of implantable medical devices and skin nutrition, and in particular relates to a cross-linked sodium hyaluronate composite solution preparation and its preparation method and application. The composite solution preparation can fill the skin wrinkles in the superficial layer of the skin, and can nourish the extracellular matrix of the skin. Background technique [0002] Due to genetic and environmental factors, the skin will gradually age, and various skin aging symptoms will appear. Wrinkles are one of the symptoms. The common ones are facial wrinkles, eye wrinkles, forehead lines, neck lines, hand wrinkles, and stretch marks. Wait. [0003] Chinese patent CN 104189952 B discloses an injection for correcting skin folds and a preparation method thereof, which contains high molecular weight polysaccharides, amino acids, water-soluble vitamins, L-carnosine and the like. Among them, it is mentioned that the polymer po...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/54A61L27/60
CPCA61L27/20A61L27/54A61L27/60A61L2300/252A61L2300/214A61L2300/428A61L2300/45A61L2400/06C08L5/08
Inventor 陈雄伟张堃
Owner IMEIK TECH DEV CO LTD
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