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Biosensor, preparation method and virus detection system and method

A biosensor, virus technology, applied in biochemical equipment and methods, biological testing, microbial determination/inspection, etc., can solve the problem of less virus types

Active Publication Date: 2020-07-31
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, biosensor technology has made great progress and has been applied in environmental detection, genetic detection, bacteria and virus detection, etc., but the actual types of viruses that can be detected are still relatively small

Method used

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  • Biosensor, preparation method and virus detection system and method
  • Biosensor, preparation method and virus detection system and method
  • Biosensor, preparation method and virus detection system and method

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0067] Such as Figure 1a as shown, Figure 1a A schematic structural diagram of a graphene-based biosensor provided in an embodiment of the present invention, the biosensor includes: Si / SiO 2 Substrate 110 , graphene material 120 , metal electrodes (input / output) 130 , bridging molecules 140 and COVID-19 antigen 150 .

[0068] Among them, Si / SiO 2 The substrate 110 is made of the silicon Si material layer located in the lower layer and the silicon dioxide SiO closely combined with it. 2 Material layer composition. SiO 2 The function of is to prevent the interference caused by the bottom leakage to the signal detection. Si / SiO 2 The substrate 110 can be Si / SiO purchased in the market 2 Silicon Wafer, Si / SiO 2 The silicon wafer is integrated, and the silicon Si wafer has been covered with SiO 2 layer.

[0069] The base layer in the embodiment of the present invention is not limited to Si / SiO 2 substrate, in other embodiments the Si / SiO can be replaced by other insulati...

Embodiment 2

[0085] Such as figure 2 as shown, figure 2 The second schematic structural diagram of the graphene-based biosensor provided by the embodiment of the present invention; the biosensor includes: Si / SiO 2 Substrate 210 , graphene material 220 , metal electrodes (input / output) 230 , bridging molecules 240 , COVID-19 antibodies 250 .

[0086] Among them, Si / SiO 2 The substrate 210 is made of the Si material layer located in the lower layer and the SiO closely combined with it. 2 Material layer composition. SiO 2 The function of is to prevent the interference caused by the bottom leakage to the signal detection. Si / SiO 2 Substrate 210 can be Si / SiO purchased in the market 2 Silicon Wafer, Si / SiO 2 The silicon wafer is integrated, and the silicon Si wafer has been covered with SiO 2 layer.

[0087] Graphene material 220 on Si / SiO 2 The upper layer of the substrate 210 forms the graphene layer.

[0088] Metal electrodes (input / output) 230 are plated on the graphene materi...

Embodiment 3

[0095] Such as image 3 as shown, image 3 The third schematic structural diagram of the graphene-based biosensor provided by the embodiment of the present invention; the biosensor includes: Si / SiO 2 Substrate 310 , graphene material 320 , metal electrodes (input / output) 330 , bridging molecules 340 , nucleic acid probes 350 and optional heating plate 360 ​​.

[0096] Among them, Si / SiO 2 The substrate 310 is made of the Si material layer located at the lower layer and the SiO closely combined with it 2 Material layer composition. SiO 2 The function of is to prevent the interference caused by the bottom leakage to the signal detection. Si / SiO 2 The substrate 310 can be Si / SiO purchased in the market 2 Silicon Wafer, Si / SiO 2 The silicon wafer is integrated, and the silicon Si wafer has been covered with SiO 2 layer.

[0097] Graphene material 320 on Si / SiO 2 The upper layer of the substrate 310 forms the graphene layer.

[0098] Metal electrodes (input / output) 330 ...

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Abstract

The embodiment of the invention provides a biosensor, a preparation method, a virus detection system and method. The method comprises the following steps: modifying a virus antigen or a virus antibodyor a nucleic acid probe for detecting viruses on a biosensor through bridging molecules capable of connecting various biomacromolecules, inputting a to-be-detected sample into the biosensor, and analyzing current signals before and after reaction, so as to detect whether viruses exist in the to-be-detected sample or not. The bridging molecule of the biosensor provided by the embodiment of the invention can be connected with various biomacromolecules, so that different viruses can be detected.

Description

technical field [0001] The invention relates to the technical field of biological detection, in particular to a biosensor and its preparation method, and a virus detection system and method. Background technique [0002] A bioelectric sensor is a sensor that uses immobilized biological components or organisms as sensitive elements. The basic principle is to detect the change of current or voltage caused by the biological action or chemical reaction between the sensitive element and the biological component or organism to be detected, and determine the detection result according to the change of current or voltage. [0003] At present, biosensor technology has been greatly developed and has been applied in environmental detection, genetic detection, bacteria and virus detection, etc., but the actual types of viruses that can be detected are still relatively small. Contents of the invention [0004] The purpose of the embodiment of the present invention is to provide a bios...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/569C12Q1/70C12Q1/6837G01N27/327G01N27/30
CPCC12Q1/6837C12Q1/701G01N27/308G01N27/3275G01N27/3278G01N33/56983G01N33/68C12Q2565/607Y02A50/30
Inventor 郭雪峰李渝
Owner PEKING UNIV
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