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Medical application of PF429242 in protection of cerebral ischemia-reperfusion injury

A technology of cerebral ischemia-reperfusion and purpose, applied in the medical field, can solve problems such as not many drugs

Active Publication Date: 2020-08-04
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, many researchers have done a lot of work on how to prevent and treat related diseases caused by cerebral ischemia, but there are not many drugs that can achieve the expected therapeutic effect

Method used

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  • Medical application of PF429242 in protection of cerebral ischemia-reperfusion injury
  • Medical application of PF429242 in protection of cerebral ischemia-reperfusion injury
  • Medical application of PF429242 in protection of cerebral ischemia-reperfusion injury

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Embodiment Construction

[0025] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0026] In this example, the model of global cerebral ischemia-reperfusion with the four-vessel method was adopted, and the pathological and morphological analysis of the neural brain cells was carried out by Nissl staining in the CA1 region of the hippocampus. Neurological function score (see Table 1), nimodipine is the standard control drug.

[0027] Table 1 Scoring ...

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Abstract

The invention discloses a medical application of PF429242 in protection of ischemia reperfusion injury. Specifically, the invention provides an application of PF429242, an enantiomer thereof, a racemate thereof or pharmaceutically acceptable salt thereof in screening and preparing medicines for preventing and / or treating cerebral ischemia-reperfusion injury. A large number of experiments prove that the PF429242, the enantiomer, the racemate or the pharmaceutically acceptable salt of the PF429242 can effectively reduce brain cell injury and dysfunction caused by cerebral ischemia-reperfusion ofrats, and has an obvious protective effect on neurobrain cells.

Description

technical field [0001] The invention relates to a medical application of PF429242, in particular to the medical application of PF429242, its enantiomer, its racemate or a pharmaceutically acceptable salt thereof for protecting cerebral ischemia-reperfusion injury, belonging to the field of medical technology . Background technique [0002] Cerebrovascular disease has become one of the three major diseases leading to human death due to its high morbidity, disability and mortality, and seriously endangers human health. So far, the primary principle of clinical treatment for cerebrovascular diseases is to restore or rebuild blood reperfusion as soon as possible, so that ischemic brain tissue can regain oxygen supply, provide nutrients needed for metabolism and remove metabolites. On the one hand, these treatment measures can timely reperfuse the occluded cerebral blood vessels and ischemic brain tissue, save a large number of brain cells on the verge of death, and facilitate t...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61P9/10
CPCA61K31/40A61P9/10
Inventor 徐洲翟荣良吴楠温相如李闯郑岩
Owner XUZHOU MEDICAL UNIV
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